Imp5 Gene Search Result

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1551065	Ipo5	importin 5	Enables nuclear import signal receptor activity. Involved in NLS-bearing protein import into nucleus; cellular response to amino acid stimulus; and positive regulation of protein import into nucleus. Located in cytoplasm and nucleus. Is expressed in cerebral cortex and gonad. Orthologous to human IP ... (more) O5 (importin 5). [provided by Alliance of Genome Resources, Jul 2025]	14	121134271	121185451	Mouse	166	old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
1603712	IPO5	importin 5	Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits ... (more) also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]	13	97953675	98024296	Human	177	old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
1560562	Sppl2c	signal peptide peptidase like 2C	ENCODES a protein that exhibits aspartic endopeptidase activity, intramembrane cleaving (ortholog); aspartic-type endopeptidase activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN acrosome assembly (ortholog); fusion of sperm to egg plasma membrane involved in single fertilizatio ... (more) n (ortholog); intracellular calcium ion homeostasis (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); FOUND IN cytoplasmic side of endoplasmic reticulum membrane (ortholog); endoplasmic reticulum membrane (ortholog); lumenal side of endoplasmic reticulum membrane (ortholog); INTERACTS WITH bisphenol A; genistein; 4,4'-sulfonyldiphenol (ortholog)	10	89595265	89597470	Rat	54	old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
1606947	SPPL2C	signal peptide peptidase like 2C	Enables protein homodimerization activity. Predicted to be involved in several processes, including acrosome assembly; fusion of sperm to egg plasma membrane involved in single fertilization; and membrane protein intracellular domain proteolysis. Located in cytoplasmic side of endoplasmic reticulum ... (more) membrane and lumenal side of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]	17	45844881	45847067	Human	51	old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
1623763	Sppl2c	signal peptide peptidase 2C	Enables aspartic endopeptidase activity, intramembrane cleaving and molecular adaptor activity. Involved in several processes, including acrosome assembly; fusion of sperm to egg plasma membrane involved in single fertilization; and protein stabilization. Acts upstream of or within several processes ... (more) , including maintenance of protein localization in endoplasmic reticulum; protein localization involved in acrosome reaction; and sperm-egg recognition. Located in endoplasmic reticulum membrane. Orthologous to human SPPL2C (signal peptide peptidase like 2C). [provided by Alliance of Genome Resources, Apr 2025]	11	104077153	104081992	Mouse	59	old_gene_name , old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
12305485	SPPL2C	signal peptide peptidase like 2C	ENCODES a protein that exhibits aspartic endopeptidase activity, intramembrane cleaving (inferred); aspartic-type endopeptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN membrane protein ectodomain proteolysis (ortholog); membrane protein intracellular domain proteolysis (ortho ... (more) log); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog)	9	9703119	9705300	Dog	31	old_gene_symbol	gene, protein-coding, MODEL [RefSeq]