| 1307024 | Ikzf3 | IKAROS family zinc finger 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); identical protein binding (ortholog); INVOLVED IN B cell differentiation (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); regulation of apoptotic process (ortholog); PARTICIPATES IN interleukin-2 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); asthma (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acetamide | 10 | 83956850 | 84049861 | Rat | 134 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1315971 | IKZF3 | IKAROS family zinc finger 3 | This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is importa nt in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012] | 17 | 39757715 | 39864312 | Human | 144 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1315972 | Ikzf3 | IKAROS family zinc finger 3 | Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in lymphocyte differentiation; positive regulation of transcription by RNA polymerase II; and regulation of B cell a ctivation. Acts upstream of or within response to bacterium. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and liver and biliary system. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in immunodeficiency 84. Orthologous to human IKZF3 (IKAROS family zinc finger 3). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 98355436 | 98437157 | Mouse | 176 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8971412 | Ikzf3 | IKAROS family zinc finger 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); identical protein binding (ortholog); INVOLVED IN B cell differentiation (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); regulation of apoptotic process (ortholog); PARTICIPATES IN interleukin-2 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); asthma (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004955451 | 14483669 | 14571108 | Chinchilla | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12029636 | IKZF3 | IKAROS family zinc finger 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN response to bacterium (ortholog); PARTICIPATES IN interleukin-2 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); asthma (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 17 | 17459438 | 17498452 | Bonobo | 70 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12165379 | IKZF3 | IKAROS family zinc finger 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN response to bacterium (ortholog); PARTICIPATES IN interleukin-2 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); asthma (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 9 | 22643482 | 22733988 | Dog | 68 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12710851 | Ikzf3 | IKAROS family zinc finger 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN response to bacterium (ortholog); PARTICIPATES IN interleukin-2 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); asthma (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | NW_004936490 | 14939693 | 15025728 | Squirrel | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248827 | ikzf3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18528845 | IKZF3 | IKAROS family zinc finger 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN response to bacterium (ortholog); PARTICIPATES IN interleukin-2 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); asthma (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 67 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18903173 | Ikzf3 | IKAROS family zinc finger 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); identical protein binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); regulation of apoptotic process (ortholog); regulation of B cell differentiation (ortholog); PARTICIPATES IN interleukin-2 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); asthma (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 70 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626045888 | Ikzf3 | IKAROS family zinc finger 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); identical protein binding (ortholog); INVOLVED IN B cell differentiation (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); regulation of apoptotic process (ortholog); PARTICIPATES IN interleukin-2 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); asthma (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14053866 | IKZF3 | IKAROS family zinc finger 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN response to bacterium (ortholog); PARTICIPATES IN interleukin-2 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); asthma (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Pig | 68 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248828 | ikzf3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155260254 | ikzf3.S | | | | | | African Clawed Frog | | symbol | gene, null |