ENCODES a protein that exhibits GTP binding (inferred); hydrolase activity (inferred); nucleotide binding (inferred); PARTICIPATES IN toxoplasmosis pathway; FOUND IN membrane (inferred); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate
Enables GTPase activity. Involved in several processes, including defense response to other organism; negative regulation of PERK-mediated unfolded protein response; and positive regulation of autophagosome maturation. Acts upstream of or within cellular response to interferon-beta. Located in cytos
ol. Is active in endoplasmic reticulum. Is expressed in alimentary system; hemolymphoid system; liver; thymus primordium; and tongue. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M). [provided by Alliance of Genome Resources, Jul 2025]