| 2873 | Igfbp2 | insulin-like growth factor binding protein 2 | ENCODES a protein that exhibits insulin-like growth factor I binding; insulin-like growth factor II binding; insulin-like growth factor binding (ortholog); INVOLVED IN cellular response to hormone stimulus; female pregnancy; response to estradiol; PARTICIPATES IN insulin-like growth factor signaling pathway; ASSOCIATED WITH Experimental Diabetes Mellitus; Hyperoxia; hypertension; FOUND IN apical plasma membrane; extracellular region; extracellular space; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol | 9 | 81864811 | 81892179 | Rat | 349 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10771 | Igfbp2 | insulin-like growth factor binding protein 2 | The protein encoded by this gene is one of several similar proteins that bind insulin-like growth factors I and II (Igf-I and Igf-II). The encoded protein can be secreted into the bloodstream, where it binds Igf-I and Igf-II with high affinity, or it can remain intracellular, interacting with many d ifferent ligands. Two transcript variants, one encoding a secreted isoform and the other encoding a nonsecreted isoform, have been found for this gene. [provided by RefSeq, Sep 2015] | 1 | 72863650 | 72891633 | Mouse | 371 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 737357 | IGFBP2 | insulin like growth factor binding protein 2 | The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many diffe rent ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015] | 2 | 216632828 | 216664436 | Human | 356 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8773662 | Igfbp2 | insulin like growth factor binding protein 2 | ENCODES a protein that exhibits insulin-like growth factor binding (ortholog); insulin-like growth factor I binding (ortholog); insulin-like growth factor II binding (ortholog); INVOLVED IN cellular response to hormone stimulus (ortholog); female pregnancy (ortholog); osteoblast differentiation (ort holog); PARTICIPATES IN insulin-like growth factor signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); contact dermatitis (ortholog); FOUND IN apical plasma membrane (ortholog); extracellular region (ortholog); extracellular space (ortholog) | NW_004955453 | 16556873 | 16584737 | Chinchilla | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11906097 | IGFBP2 | insulin like growth factor binding protein 2 | ENCODES a protein that exhibits insulin-like growth factor binding (ortholog); insulin-like growth factor I binding (ortholog); insulin-like growth factor II binding (ortholog); INVOLVED IN cellular response to hormone stimulus (ortholog); female pregnancy (ortholog); osteoblast differentiation (ort holog); PARTICIPATES IN insulin-like growth factor signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); contact dermatitis (ortholog); FOUND IN apical plasma membrane (ortholog); extracellular region (ortholog); extracellular space (ortholog) | 2B | 103893724 | 103925318 | Bonobo | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12169107 | IGFBP2 | insulin like growth factor binding protein 2 | ENCODES a protein that exhibits insulin-like growth factor I binding (ortholog); insulin-like growth factor II binding (ortholog); INVOLVED IN cellular response to hormone stimulus (ortholog); female pregnancy (ortholog); positive regulation of growth (ortholog); PARTICIPATES IN insulin-like growth factor signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); contact dermatitis (ortholog); FOUND IN apical plasma membrane (ortholog); extracellular space (ortholog) | 37 | 23553227 | 23569321 | Dog | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12507000 | Igfbp2 | insulin like growth factor binding protein 2 | ENCODES a protein that exhibits insulin-like growth factor I binding (ortholog); insulin-like growth factor II binding (ortholog); INVOLVED IN cellular response to hormone stimulus (ortholog); female pregnancy (ortholog); positive regulation of growth (ortholog); PARTICIPATES IN insulin-like growth factor signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); contact dermatitis (ortholog); FOUND IN apical plasma membrane (ortholog); extracellular space (ortholog) | NW_004936586 | 671760 | 696783 | Squirrel | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626038888 | Igfbp2 | insulin like growth factor binding protein 2 | ENCODES a protein that exhibits insulin-like growth factor binding (ortholog); insulin-like growth factor I binding (ortholog); insulin-like growth factor II binding (ortholog); INVOLVED IN cellular response to hormone stimulus (ortholog); female pregnancy (ortholog); osteoblast differentiation (ort holog); PARTICIPATES IN insulin-like growth factor signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); contact dermatitis (ortholog); FOUND IN apical plasma membrane (ortholog); extracellular region (ortholog); extracellular space (ortholog) | | | | Black Rat | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242165 | igfbp2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18612181 | IGFBP2 | insulin like growth factor binding protein 2 | ENCODES a protein that exhibits insulin-like growth factor I binding (ortholog); insulin-like growth factor II binding (ortholog); INVOLVED IN cellular response to hormone stimulus (ortholog); female pregnancy (ortholog); positive regulation of growth (ortholog); PARTICIPATES IN insulin-like growth factor signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); contact dermatitis (ortholog); FOUND IN apical plasma membrane (ortholog); extracellular space (ortholog) | | | | Green Monkey | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907273 | Igfbp2 | insulin like growth factor binding protein 2 | ENCODES a protein that exhibits insulin-like growth factor I binding (ortholog); insulin-like growth factor II binding (ortholog); receptor ligand inhibitor activity (ortholog); INVOLVED IN cellular response to hormone stimulus (ortholog); female pregnancy (ortholog); osteoblast differentiation (ort holog); PARTICIPATES IN insulin-like growth factor signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); contact dermatitis (ortholog); FOUND IN apical plasma membrane (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14113654 | IGFBP2 | insulin like growth factor binding protein 2 | ENCODES a protein that exhibits insulin-like growth factor I binding (ortholog); insulin-like growth factor II binding (ortholog); INVOLVED IN positive regulation of growth; cellular response to hormone stimulus (ortholog); female pregnancy (ortholog); PARTICIPATES IN insulin-like growth factor sign aling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); contact dermatitis (ortholog); FOUND IN apical plasma membrane (ortholog); extracellular region (ortholog); extracellular space (ortholog); INTERACTS WITH deoxynivalenol; ochratoxin A | | | | Pig | 58 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155242164 | igfbp2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155252880 | igfbp2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1602214 | MIIP | migration and invasion inhibitory protein | This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011] | 1 | 12019498 | 12032045 | Human | 52 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |