| 621805 | Hsd17b3 | hydroxysteroid (17-beta) dehydrogenase 3 | ENCODES a protein that exhibits estradiol 17-beta-dehydrogenase [NAD(P)+] activity; testosterone dehydrogenase (NAD+) activity; testosterone dehydrogenase (NADP+) activity (ortholog); INVOLVED IN cellular response to antibiotic; cellular response to gonadotropin stimulus; cellular response to hormon e stimulus; PARTICIPATES IN estradiol biosynthetic pathway; testosterone biosynthetic pathway; steroid hormone biosynthetic pathway; ASSOCIATED WITH type 2 diabetes mellitus; 17-beta hydroxysteroid dehydrogenase 3 deficiency (ortholog); Alzheimer's disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH (+)-taxifolin; (R,R,R)-alpha-tocopherol; (S)-nicotine | 17 | 1032958 | 1064283 | Rat | 282 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732551 | Hsd17b3 | hydroxysteroid (17-beta) dehydrogenase 3 | Enables testosterone dehydrogenase [NAD(P)+] activity. Involved in androgen biosynthetic process. Is active in endoplasmic reticulum membrane. Is expressed in ovary and testis. Used to study 17-beta hydroxysteroid dehydrogenase 3 deficiency. Human ortholog(s) of this gene implicated in 17-beta hydro xysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to human HSD17B3 (hydroxysteroid 17-beta dehydrogenase 3). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 64206088 | 64237076 | Mouse | 306 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1344400 | HSD17B3 | hydroxysteroid 17-beta dehydrogenase 3 | This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 20 08] | 9 | 96235306 | 96302176 | Human | 294 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9050349 | Hsd17b3 | hydroxysteroid 17-beta dehydrogenase 3 | ENCODES a protein that exhibits estradiol 17-beta-dehydrogenase [NAD(P)+] activity (ortholog); testosterone dehydrogenase (NAD+) activity (ortholog); testosterone dehydrogenase (NADP+) activity (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); cellular response to antibiotic (ortholo g); cellular response to gonadotropin stimulus (ortholog); PARTICIPATES IN estradiol biosynthetic pathway; testosterone biosynthetic pathway; ASSOCIATED WITH 17-beta hydroxysteroid dehydrogenase 3 deficiency (ortholog); Alzheimer's disease (ortholog); disorder of sexual development (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | NW_004955422 | 23104752 | 23251250 | Chinchilla | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11932133 | HSD17B3 | hydroxysteroid 17-beta dehydrogenase 3 | ENCODES a protein that exhibits estradiol 17-beta-dehydrogenase [NAD(P)+] activity (ortholog); testosterone dehydrogenase (NAD+) activity (ortholog); INVOLVED IN cellular response to antibiotic (ortholog); cellular response to gonadotropin stimulus (ortholog); cellular response to hormone stimulus ( ortholog); PARTICIPATES IN estradiol biosynthetic pathway; testosterone biosynthetic pathway; ASSOCIATED WITH 17-beta hydroxysteroid dehydrogenase 3 deficiency (ortholog); Alzheimer's disease (ortholog); disorder of sexual development (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred) | 9 | 67327047 | 67411754 | Bonobo | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12271408 | HSD17B3 | hydroxysteroid 17-beta dehydrogenase 3 | ENCODES a protein that exhibits estradiol 17-beta-dehydrogenase [NAD(P)+] activity (ortholog); testosterone dehydrogenase (NAD+) activity (ortholog); testosterone dehydrogenase (NADP+) activity (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); cellular response to antibiotic (ortholo g); cellular response to gonadotropin stimulus (ortholog); PARTICIPATES IN estradiol biosynthetic pathway; testosterone biosynthetic pathway; ASSOCIATED WITH 17-beta hydroxysteroid dehydrogenase 3 deficiency (ortholog); Alzheimer's disease (ortholog); disorder of sexual development (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | 1 | 70551013 | 70586364 | Dog | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12587705 | Hsd17b3 | hydroxysteroid 17-beta dehydrogenase 3 | ENCODES a protein that exhibits estradiol 17-beta-dehydrogenase [NAD(P)+] activity (ortholog); testosterone dehydrogenase (NAD+) activity (ortholog); INVOLVED IN cellular response to antibiotic (ortholog); cellular response to gonadotropin stimulus (ortholog); cellular response to hormone stimulus ( ortholog); PARTICIPATES IN estradiol biosynthetic pathway; testosterone biosynthetic pathway; ASSOCIATED WITH 17-beta hydroxysteroid dehydrogenase 3 deficiency (ortholog); Alzheimer's disease (ortholog); disorder of sexual development (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred) | NW_004936487 | 228301 | 282495 | Squirrel | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625973154 | Hsd17b3 | hydroxysteroid 17-beta dehydrogenase 3 | ENCODES a protein that exhibits estradiol 17-beta-dehydrogenase [NAD(P)+] activity (ortholog); testosterone dehydrogenase (NAD+) activity (ortholog); testosterone dehydrogenase (NADP+) activity (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); cellular response to antibiotic (ortholo g); cellular response to gonadotropin stimulus (ortholog); PARTICIPATES IN estradiol biosynthetic pathway; testosterone biosynthetic pathway; ASSOCIATED WITH 17-beta hydroxysteroid dehydrogenase 3 deficiency (ortholog); Alzheimer's disease (ortholog); disorder of sexual development (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Black Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284232947 | hsd17b3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13866682 | HSD17B3 | hydroxysteroid 17-beta dehydrogenase 3 | ENCODES a protein that exhibits estradiol 17-beta-dehydrogenase [NAD(P)+] activity (ortholog); testosterone dehydrogenase (NAD+) activity (ortholog); INVOLVED IN cellular response to antibiotic (ortholog); cellular response to gonadotropin stimulus (ortholog); cellular response to hormone stimulus ( ortholog); PARTICIPATES IN estradiol biosynthetic pathway; testosterone biosynthetic pathway; ASSOCIATED WITH 17-beta hydroxysteroid dehydrogenase 3 deficiency (ortholog); Alzheimer's disease (ortholog); disorder of sexual development (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred) | | | | Pig | 46 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18903075 | Hsd17b3 | hydroxysteroid 17-beta dehydrogenase 3 | ENCODES a protein that exhibits estradiol 17-beta-dehydrogenase [NAD(P)+] activity (ortholog); testosterone dehydrogenase (NAD+) activity (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); cellular response to antibiotic (ortholog); cellular response to gonadotropin stimulus (ortholog ); PARTICIPATES IN estradiol biosynthetic pathway; testosterone biosynthetic pathway; ASSOCIATED WITH 17-beta hydroxysteroid dehydrogenase 3 deficiency (ortholog); Alzheimer's disease (ortholog); disorder of sexual development (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Naked Mole-Rat | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18519189 | HSD17B3 | hydroxysteroid 17-beta dehydrogenase 3 | ENCODES a protein that exhibits estradiol 17-beta-dehydrogenase [NAD(P)+] activity (ortholog); testosterone dehydrogenase (NAD+) activity (ortholog); INVOLVED IN cellular response to antibiotic (ortholog); cellular response to gonadotropin stimulus (ortholog); cellular response to hormone stimulus ( ortholog); PARTICIPATES IN estradiol biosynthetic pathway; testosterone biosynthetic pathway; ASSOCIATED WITH 17-beta hydroxysteroid dehydrogenase 3 deficiency (ortholog); Alzheimer's disease (ortholog); disorder of sexual development (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred) | | | | Green Monkey | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 329332923 | hsd17b3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 12790881 | HSD17B3-AS1 | HSD17B3 antisense RNA 1 | | 9 | 96246463 | 96250261 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 155663635 | SLC35D2-HSD17B3 | SLC35D2-HSD17B3 readthrough | This locus represents naturally occurring readthrough transcription between the neighboring SLC35D2 (solute carrier family 35 member D2) and HSD17B3 (hydroxysteroid 17-beta dehydrogenase 3) genes on chromosome 9. The readthrough transcript is a candidate for non sense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Nov 2022] | 9 | 96235306 | 96383711 | Human | 2 | symbol , COSMIC , name , description , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |