| 1309797 | Hoxd12 | homeo box D12 | ENCODES a protein that exhibits sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN embryonic digit morphogenesis (ortholog); pattern specification process (ortholog); skeletal system development (ortholog); ASSOCIATED WITH clubfoot (ortholog); Congenital Limb Deformities (ortholog ); melanoma (ortholog); FOUND IN transcription regulator complex (ortholog); INTERACTS WITH bisphenol A; paracetamol; vinclozolin | 3 | 79985106 | 79986227 | Rat | 50 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1320327 | HOXD12 | homeobox D12 | This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on diff erent chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. [provided by RefSeq, Jul 2008] | 2 | 176099795 | 176102489 | Human | 47 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1320328 | Hoxd12 | homeobox D12 | Predicted to enable sequence-specific double-stranded DNA binding activity. Acts upstream of or within embryonic digit morphogenesis; pattern specification process; and skeletal system development. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; limb; and limb bud. Human ortholog(s) of this gene implicated in clubfoot. Orthologous to human HOXD12 (homeobox D12). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 74505357 | 74508049 | Mouse | 80 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9065935 | Hoxd12 | homeobox D12 | ENCODES a protein that exhibits sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN embryonic digit morphogenesis (ortholog); pattern specification process (ortholog); skeletal system development (ortholog); ASSOCIATED WITH clubfoot (ortholog); Congenital Limb Deformities (ortholog ); melanoma (ortholog); FOUND IN transcription regulator complex (ortholog) | NW_004955403 | 20562248 | 20563205 | Chinchilla | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11842514 | HOXD12 | homeobox D12 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); sequence-specific double-stranded DNA binding (inferred); INVOLVED IN embryonic digit morphogenesis (ortholog); pattern specification process (ortholog); skeletal system development (ortholog); ASSOCIATED WITH clubfoot (ortholog); Congenital Limb Deformities (ortholog); melanoma (ortholog); FOUND IN nucleus (inferred); transcription regulator complex (inferred) | 2B | 63379611 | 63382293 | Bonobo | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12367351 | HOXD12 | homeobox D12 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); sequence-specific double-stranded DNA binding (inferred); INVOLVED IN embryonic digit morphogenesis (ortholog); pattern specification process (ortholog); skeletal system development (ortholog); ASSOCIATED WITH clubfoot (ortholog); Congenital Limb Deformities (ortholog); melanoma (ortholog); FOUND IN nucleus (inferred); transcription regulator complex (inferred) | 36 | 19907424 | 19910827 | Dog | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12640836 | Hoxd12 | homeobox D12 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); sequence-specific double-stranded DNA binding (inferred); INVOLVED IN embryonic digit morphogenesis (ortholog); pattern specification process (ortholog); skeletal system development (ortholog); ASSOCIATED WITH clubfoot (ortholog); Congenital Limb Deformities (ortholog); melanoma (ortholog); FOUND IN nucleus (inferred); transcription regulator complex (inferred) | NW_004936509 | 5586772 | 5587730 | Squirrel | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14168424 | HOXD12 | homeobox D12 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); sequence-specific double-stranded DNA binding (inferred); INVOLVED IN embryonic digit morphogenesis (ortholog); pattern specification process (ortholog); skeletal system development (ortholog); ASSOCIATED WITH clubfoot (ortholog); Congenital Limb Deformities (ortholog); melanoma (ortholog); FOUND IN nucleus (inferred); transcription regulator complex (inferred) | | | | Pig | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18923071 | Hoxd12 | homeobox D12 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); sequence-specific double-stranded DNA binding (inferred); INVOLVED IN embryonic digit morphogenesis (ortholog); pattern specification process (ortholog); skeletal system development (ortholog); ASSOCIATED WITH clubfoot (ortholog); Congenital Limb Deformities (ortholog); melanoma (ortholog); FOUND IN transcription regulator complex (ortholog) | | | | Naked Mole-Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18722033 | HOXD12 | homeobox D12 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); sequence-specific double-stranded DNA binding (inferred); INVOLVED IN embryonic digit morphogenesis (ortholog); pattern specification process (ortholog); skeletal system development (ortholog); ASSOCIATED WITH clubfoot (ortholog); Congenital Limb Deformities (ortholog); melanoma (ortholog); FOUND IN nucleus (inferred); transcription regulator complex (inferred) | | | | Green Monkey | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625912154 | Hoxd12 | homeobox D12 | ENCODES a protein that exhibits sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN embryonic digit morphogenesis (ortholog); pattern specification process (ortholog); skeletal system development (ortholog); ASSOCIATED WITH clubfoot (ortholog); Congenital Limb Deformities (ortholog ); melanoma (ortholog); FOUND IN transcription regulator complex (ortholog) | | | | Black Rat | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |