Hecw2 Gene Search Result

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12 records found for search term Hecw2

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1349400	HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angioge ... (more) nesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]	2	196194072	196593554	Human	194	symbol , old_gene_name , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1557475	Hecw2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in regulation of dendrite morphogenesis; regulation of mitotic metaphase/anaphase transition; and ubiquitin-dependent protein catabolic process. Predicted to be located in mitotic spindle. Predicted to be active in cytop ... (more) lasm. Orthologous to human HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Jul 2025]	1	53846031	54234193	Mouse	141	symbol , old_gene_name , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
1593244	Hecw2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	ENCODES a protein that exhibits transferase activity (inferred); ubiquitin protein ligase activity (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN regulation of mitotic metaphase/anaphase transition (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 11 ... (more) (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN mitotic spindle (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine	9	62853904	63247472	Rat	130	symbol , old_gene_name , PhenoGen	gene, protein-coding, PROVISIONAL [RefSeq]
8919052	Hecw2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	INVOLVED IN regulation of mitotic metaphase/anaphase transition (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 11 (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN mitotic spindle (ortholog)	NW_004955403	3902881	4096189	Chinchilla	15	symbol , old_gene_name	gene, protein-coding, MODEL [RefSeq]
11989421	HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	ENCODES a protein that exhibits transferase activity (inferred); ubiquitin protein ligase activity (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN protein ubiquitination (inferred); regulation of dendrite morphogenesis (inferred); regulation of mitotic metaphase/anaphase t ... (more) ransition (inferred); ASSOCIATED WITH developmental and epileptic encephalopathy 11 (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); mitotic spindle (inferred)	2B	83445401	83838065	Bonobo	25	symbol , old_gene_name	gene, protein-coding, MODEL [RefSeq]
12183648	HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	ENCODES a protein that exhibits transferase activity (inferred); ubiquitin protein ligase activity (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN protein ubiquitination (inferred); regulation of mitotic metaphase/anaphase transition (inferred); ASSOCIATED WITH development ... (more) al and epileptic encephalopathy 11 (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); mitotic spindle (inferred)	37	5850518	6213353	Dog	24	symbol , old_gene_name	gene, protein-coding, MODEL [RefSeq]
12537491	Hecw2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	ENCODES a protein that exhibits transferase activity (inferred); ubiquitin protein ligase activity (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN protein ubiquitination (inferred); regulation of dendrite morphogenesis (inferred); regulation of mitotic metaphase/anaphase t ... (more) ransition (inferred); ASSOCIATED WITH developmental and epileptic encephalopathy 11 (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); mitotic spindle (inferred)	NW_004936506	2704885	2913663	Squirrel	25	symbol , old_gene_name	gene, protein-coding, MODEL [RefSeq]
625850750	Hecw2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	INVOLVED IN regulation of mitotic metaphase/anaphase transition (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 11 (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN mitotic spindle (ortholog)				Black Rat	15	symbol , old_gene_name	gene, protein-coding, MODEL [RefSeq]
18904814	Hecw2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	ENCODES a protein that exhibits transcription coactivator activity (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN regulation of mitotic metaphase/anaphase transition (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 11 (ort ... (more) holog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN mitotic spindle (ortholog)				Naked Mole-Rat	31	symbol , old_gene_name	gene, protein-coding, MODEL [RefSeq]
14003616	HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	ENCODES a protein that exhibits transferase activity (inferred); ubiquitin protein ligase activity (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN protein ubiquitination (inferred); regulation of mitotic metaphase/anaphase transition (inferred); ASSOCIATED WITH development ... (more) al and epileptic encephalopathy 11 (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); mitotic spindle (inferred)				Pig	24	symbol , old_gene_name	gene, protein-coding, PROVISIONAL [RefSeq]
18379907	HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	ENCODES a protein that exhibits transferase activity (inferred); ubiquitin protein ligase activity (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN protein ubiquitination (inferred); regulation of dendrite morphogenesis (inferred); regulation of mitotic metaphase/anaphase t ... (more) ransition (inferred); ASSOCIATED WITH developmental and epileptic encephalopathy 11 (ortholog); Developmental Disease (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); mitotic spindle (inferred)				Green Monkey	25	symbol , old_gene_name	gene, protein-coding, MODEL [RefSeq]
13793233	HECW2-AS1	HECW2 antisense RNA 1		2	196260024	196264204	Human		symbol , COSMIC , name , Human Proteome Map	gene, ncrna, VALIDATED [RefSeq]