| 1345622 | HCFC1 | host cell factor C1 | This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] | X | 153947557 | 153971818 | Human | 243 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1557256 | Hcfc1 | host cell factor C1 | This gene encodes a transcription cofactor that regulates the progression of cell cycle and maintain the ability of embryonic stem cells to self-renew. The encoded protein is a large precursor that undergoes site-specific proteolytic cleavage to yield N- and C-terminal chains that form a non-covalen t heterodimer. The encoded protein has been implicated in the regulation of expression of immediate early genes after herpes simplex virus infection and glucose-stimulated secretion of insulin by pancreatic beta cells. [provided by RefSeq, Aug 2015] | X | 72986400 | 73011430 | Mouse | 224 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1563804 | Hcfc1 | host cell factor C1 | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA-binding transcription factor binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II; positive regulation of insulin secretion involved in cellular response to glucos e stimulus; positive regulation of transcription by RNA polymerase II; PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autistic disorder (ortholog); Emery-Dreifuss muscular dystrophy (ortholog); genetic disease (ortholog); FOUND IN axon; dendrite; nuclear chromosome; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene | X | 156839100 | 156864132 | Rat | 174 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 9034969 | Hcfc1 | host cell factor C1 | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA-binding transcription factor binding (ortholog); INVOLVED IN blastocyst hatching (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of DNA-templated transcription (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autistic disorder (ortholog); Emery-Dreifuss muscular dystrophy (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); dendrite (ortholog) | NW_004955580 | 616477 | 636849 | Chinchilla | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11860779 | HCFC1 | host cell factor C1 | ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); DNA-binding transcription factor binding (inferred); INVOLVED IN blastocyst hatching (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of insulin secret ion involved in cellular response to glucose stimulus (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autistic disorder (ortholog); Emery-Dreifuss muscular dystrophy (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); nuclear chromosome (ortholog) | X | 143502159 | 143526418 | Bonobo | 83 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12304229 | HCFC1 | host cell factor C1 | ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); DNA-binding transcription factor binding (inferred); INVOLVED IN blastocyst hatching (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of insulin secret ion involved in cellular response to glucose stimulus (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autistic disorder (ortholog); Emery-Dreifuss muscular dystrophy (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); nuclear chromosome (ortholog) | X | 121790585 | 121815395 | Dog | 81 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12462642 | Hcfc1 | host cell factor C1 | ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); DNA-binding transcription factor binding (inferred); INVOLVED IN blastocyst hatching (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of insulin secret ion involved in cellular response to glucose stimulus (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autistic disorder (ortholog); Emery-Dreifuss muscular dystrophy (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); nuclear chromosome (ortholog) | NW_004936809 | 827008 | 853689 | Squirrel | 81 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14029265 | HCFC1 | host cell factor C1 | ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); DNA-binding transcription factor binding (inferred); INVOLVED IN blastocyst hatching (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of insulin secret ion involved in cellular response to glucose stimulus (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autistic disorder (ortholog); Emery-Dreifuss muscular dystrophy (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); nuclear chromosome (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 82 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18575486 | HCFC1 | host cell factor C1 | ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); DNA-binding transcription factor binding (inferred); INVOLVED IN blastocyst hatching (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of insulin secret ion involved in cellular response to glucose stimulus (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autistic disorder (ortholog); Emery-Dreifuss muscular dystrophy (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); nuclear chromosome (ortholog) | | | | Green Monkey | 83 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18932309 | Hcfc1 | host cell factor C1 | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA-binding transcription factor binding (ortholog); INVOLVED IN blastocyst hatching (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of gene expressio n (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autistic disorder (ortholog); Emery-Dreifuss muscular dystrophy (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); histone acetyltransferase complex (ortholog) | | | | Naked Mole-Rat | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155260219 | hcfc1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626114567 | Hcfc1 | host cell factor C1 | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA-binding transcription factor binding (ortholog); INVOLVED IN blastocyst hatching (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of DNA-templated transcription (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autistic disorder (ortholog); Emery-Dreifuss muscular dystrophy (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); dendrite (ortholog) | | | | Black Rat | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405857804 | hcfc1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858303 | hcfc1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863575 | hcfc1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864418 | hcfc1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626177946 | hcfc1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259871 | hcfc1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6481339 | HCFC1-AS1 | HCFC1 antisense RNA 1 | INTERACTS WITH 2-hydroxypropanoic acid; rac-lactic acid | X | 153968765 | 153970091 | Human | 2 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 727975 | Hcfc1r1 | host cell factor C1 regulator 1 | FOUND IN cytoplasm (inferred); nucleus (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; ammonium chloride | 10 | 13209757 | 13211445 | Rat | 77 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1351730 | HCFC1R1 | host cell factor C1 regulator 1 | Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 3022620 | 3024286 | Human | 77 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1614035 | Hcfc1r1 | host cell factor C1 regulator 1 (XPO1-dependent) | Predicted to be located in nucleoplasm. Is expressed in cranial ganglion; dorsal root ganglion; medulla oblongata lateral wall; olfactory epithelium; and ventral grey horn. Orthologous to human HCFC1R1 (host cell factor C1 regulator 1). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 23892570 | 23894499 | Mouse | 81 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8765495 | Hcfc1r1 | host cell factor C1 regulator 1 | | NW_004955442 | 14318071 | 14319549 | Chinchilla | | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11976998 | HCFC1R1 | host cell factor C1 regulator 1 | | 16 | 1964465 | 1966126 | Bonobo | | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12222223 | HCFC1R1 | host cell factor C1 regulator 1 | | 6 | 38164215 | 38165921 | Dog | | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12560370 | Hcfc1r1 | host cell factor C1 regulator 1 | | NW_004936694 | 1147364 | 1148954 | Squirrel | | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14275255 | HCFC1R1 | host cell factor C1 regulator 1 | INTERACTS WITH deoxynivalenol; graphene oxide | | | | Pig | 2 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18552742 | HCFC1R1 | host cell factor C1 regulator 1 | | | | | Green Monkey | | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18921897 | Hcfc1r1 | host cell factor C1 regulator 1 | | | | | Naked Mole-Rat | | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626069453 | Hcfc1r1 | host cell factor C1 regulator 1 | | | | | Black Rat | | symbol | gene, protein-coding, MODEL [RefSeq] |
| 2309358 | Hcfc1r1-ps1 | host cell factor C1 regulator 1 (XPO1-dependent), pseudogene 1 | | 17 | 54197608 | 54197963 | Mouse | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 14996204 | Hcfc1r1-ps2 | host cell factor C1 regulator 1 (XPO1-dependent), pseudogene 2 | | 17 | 54095951 | 54096299 | Mouse | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |