| 1309638 | Guk1 | guanylate kinase 1 | ENCODES a protein that exhibits GMP kinase activity; ATP binding (ortholog); nucleoside monophosphate kinase activity (ortholog); INVOLVED IN dATP metabolic process; dGDP biosynthetic process; dGMP metabolic process; PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine mono phosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus; mitochondrial DNA depletion syndrome-21 (ortholog); FOUND IN cytosol (ortholog); mitochondrion (ortholog); photoreceptor inner segment (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol | 10 | 44471075 | 44488332 | Rat | 138 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1320084 | GUK1 | guanylate kinase 1 | The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different iso forms have been found for this gene. [provided by RefSeq, Jun 2011] | 1 | 228140084 | 228148955 | Human | 156 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1320085 | Guk1 | guanylate kinase 1 | Enables ATP binding activity and guanylate kinase activity. Involved in purine nucleotide metabolic process. Located in cytosol and photoreceptor inner segment. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory org an. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome-21. Orthologous to human GUK1 (guanylate kinase 1). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 59074696 | 59083068 | Mouse | 152 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8795656 | Guk1 | guanylate kinase 1 | ENCODES a protein that exhibits ATP binding (ortholog); GMP kinase activity (ortholog); nucleoside monophosphate kinase activity (ortholog); INVOLVED IN dATP metabolic process (ortholog); dGDP biosynthetic process (ortholog); dGMP metabolic process (ortholog); PARTICIPATES IN adenine phoshoribosyltr ansferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); mitochondrial DNA depletion syndrome-21 (ortholog); FOUND IN cytosol (ortholog); mitochondrion (ortholog); photoreceptor inner segment (ortholog) | NW_004955581 | 299010 | 305032 | Chinchilla | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11763180 | GUK1 | guanylate kinase 1 | ENCODES a protein that exhibits GMP kinase activity (ortholog); nucleoside monophosphate kinase activity (ortholog); INVOLVED IN dATP metabolic process (ortholog); dGDP biosynthetic process (ortholog); dGMP metabolic process (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pat hway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); mitochondrial DNA depletion syndrome-21 (ortholog); FOUND IN mitochondrion (ortholog) | 1 | 203541866 | 203550827 | Bonobo | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12202290 | GUK1 | guanylate kinase 1 | ENCODES a protein that exhibits GMP kinase activity (ortholog); INVOLVED IN dATP metabolic process (ortholog); dGDP biosynthetic process (ortholog); dGMP metabolic process (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pa thway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); mitochondrial DNA depletion syndrome-21 (ortholog); FOUND IN mitochondrion (ortholog) | 14 | 820048 | 826694 | Dog | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12512966 | Guk1 | guanylate kinase 1 | ENCODES a protein that exhibits GMP kinase activity (ortholog); nucleoside monophosphate kinase activity (ortholog); INVOLVED IN dATP metabolic process (ortholog); dGDP biosynthetic process (ortholog); dGMP metabolic process (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pat hway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); mitochondrial DNA depletion syndrome-21 (ortholog); FOUND IN mitochondrion (ortholog) | NW_004936864 | 76707 | 86479 | Squirrel | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14373011 | GUK1 | | | | | | Yeast | | symbol | gene, null |
| 18925451 | Guk1 | guanylate kinase 1 | ENCODES a protein that exhibits GMP kinase activity (ortholog); nucleoside monophosphate kinase activity (ortholog); INVOLVED IN dATP metabolic process (ortholog); dGDP biosynthetic process (ortholog); dGMP metabolic process (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pat hway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); mitochondrial DNA depletion syndrome-21 (ortholog); FOUND IN mitochondrion (ortholog) | | | | Naked Mole-Rat | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14021218 | GUK1 | guanylate kinase 1 | ENCODES a protein that exhibits nucleoside monophosphate kinase activity; ATP binding (ortholog); GMP kinase activity (ortholog); INVOLVED IN dATP metabolic process (ortholog); dGDP biosynthetic process (ortholog); dGMP metabolic process (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase d eficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); mitochondrial DNA depletion syndrome-21 (ortholog); FOUND IN cytosol (ortholog); mitochondrion (ortholog); photoreceptor inner segment (ortholog) | | | | Pig | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18390580 | GUK1 | guanylate kinase 1 | ENCODES a protein that exhibits GMP kinase activity (ortholog); nucleoside monophosphate kinase activity (ortholog); INVOLVED IN dATP metabolic process (ortholog); dGDP biosynthetic process (ortholog); dGMP metabolic process (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pat hway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus (ortholog); mitochondrial DNA depletion syndrome-21 (ortholog); FOUND IN mitochondrion (ortholog) | | | | Green Monkey | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244437 | guk1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155238192 | guk1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155246346 | guk1.S | | | | | | African Clawed Frog | | symbol | gene, null |