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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | increases expression | EXP | | 6480464 | 1, 2-Dimethylhydrazine results in increased expression of GUK1 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in increased expression of GUK1 mRNA] | CTD | PMID:22206623 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of GUK1 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GUK1 mRNA | CTD | PMID:17942748 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of GUK1 mRNA | CTD | PMID:30077407 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Polyphenols co-treated with Estradiol] results in decreased expression of GUK1 mRNA | CTD | PMID:30077407 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | EXP | | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GUK1 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of GUK1 mRNA | CTD | PMID:21570461 | 2,6-dinitrotoluene | affects expression | ISO | RGD:1309638 | 6480464 | 2, 6-dinitrotoluene affects the expression of GUK1 mRNA | CTD | PMID:21346803 | 3,3',4,4'-tetrachlorobiphenyl | multiple interactions | EXP | | 6480464 | 3 more ... | CTD | PMID:19467301 | 5-azacytidine | increases expression | ISO | RGD:1320084 | 6480464 | Azacitidine results in increased expression of GUK1 mRNA | CTD | PMID:20823114 | acetylsalicylic acid | decreases expression | ISO | RGD:1320084 | 6480464 | Aspirin results in decreased expression of GUK1 mRNA | CTD | PMID:15928584 | acrolein | multiple interactions | ISO | RGD:1320084 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of GUK1 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of GUK1 mRNA | CTD | PMID:32699268 | alpha-pinene | multiple interactions | ISO | RGD:1320084 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of GUK1 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of GUK1 mRNA | CTD | PMID:32699268 | arsane | affects methylation | ISO | RGD:1320084 | 6480464 | Arsenic affects the methylation of GUK1 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | RGD:1320084 | 6480464 | Arsenic affects the methylation of GUK1 gene | CTD | PMID:25304211 | arsenite(3-) | increases methylation | ISO | RGD:1320084 | 6480464 | arsenite results in increased methylation of GUK1 promoter | CTD | PMID:23974009 | Benzo[k]fluoranthene | decreases expression | EXP | | 6480464 | benzokfluoranthene results in decreased expression of GUK1 mRNA | CTD | PMID:26377693 | bisphenol A | increases expression | ISO | RGD:1309638 | 6480464 | bisphenol A results in increased expression of GUK1 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | RGD:1309638 | 6480464 | bisphenol A results in decreased expression of GUK1 mRNA | CTD | PMID:30816183 | calyculin a | decreases expression | EXP | | 6480464 | calyculin A results in decreased expression of GUK1 mRNA | CTD | PMID:25270620 | chloropicrin | affects expression | ISO | RGD:1320084 | 6480464 | chloropicrin affects the expression of GUK1 mRNA | CTD | PMID:26352163 | chloropicrin | decreases expression | ISO | RGD:1320084 | 6480464 | chloropicrin results in decreased expression of GUK1 mRNA | CTD | PMID:28476498 | cisplatin | multiple interactions | ISO | RGD:1320084 | 6480464 | Folic Acid affects the reaction [Cisplatin affects the expression of GUK1 mRNA] | CTD | PMID:16898872 | cisplatin | increases expression | ISO | RGD:1320084 | 6480464 | Cisplatin results in increased expression of GUK1 mRNA | CTD | PMID:27594783 | clofibrate | decreases expression | EXP | | 6480464 | Clofibrate results in decreased expression of GUK1 mRNA | CTD | PMID:17585979 | dextran sulfate | decreases expression | EXP | | 6480464 | Dextran Sulfate results in decreased expression of GUK1 protein | CTD | PMID:32272095 | dextran sulfate | multiple interactions | EXP | | 6480464 | Erianin inhibits the reaction [Dextran Sulfate results in decreased expression of GUK1 protein] | CTD | PMID:32272095 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of GUK1 mRNA | CTD | PMID:17361019, PMID:21266533 | ethanol | multiple interactions | ISO | RGD:1320084 | 6480464 | [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of GUK1 mRNA | CTD | PMID:29432896 | folic acid | multiple interactions | ISO | RGD:1320084 | 6480464 | Folic Acid affects the reaction [Cisplatin affects the expression of GUK1 mRNA] | CTD | PMID:16898872 | folic acid | multiple interactions | EXP | | 6480464 | Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in increased expression of GUK1 mRNA] | CTD | PMID:22206623 | hydralazine | multiple interactions | ISO | RGD:1320084 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of GUK1 mRNA | CTD | PMID:17183730 | lead(0) | affects expression | ISO | RGD:1320084 | 6480464 | Lead affects the expression of GUK1 mRNA | CTD | PMID:28903495 | lead(2+) | affects expression | ISO | RGD:1320084 | 6480464 | Lead affects the expression of GUK1 mRNA | CTD | PMID:28903495 | maneb | multiple interactions | EXP | | 6480464 | [Paraquat co-treated with Maneb] results in decreased expression of GUK1 mRNA | CTD | PMID:18386188 | nickel sulfate | increases expression | ISO | RGD:1320084 | 6480464 | nickel sulfate results in increased expression of GUK1 mRNA | CTD | PMID:18651567 | nimesulide | increases expression | ISO | RGD:1309638 | 6480464 | nimesulide results in increased expression of GUK1 mRNA | CTD | PMID:24136188 | ozone | multiple interactions | ISO | RGD:1320084 | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of GUK1 mRNA more ... | CTD | PMID:32699268 | paraquat | multiple interactions | EXP | | 6480464 | [Paraquat co-treated with Maneb] results in decreased expression of GUK1 mRNA | CTD | PMID:18386188 | pirinixic acid | multiple interactions | ISO | RGD:1320084 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GUK1 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of GUK1 mRNA | CTD | PMID:18301758 | potassium dichromate | increases expression | ISO | RGD:1320084 | 6480464 | Potassium Dichromate results in increased expression of GUK1 protein | CTD | PMID:23718831 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of GUK1 mRNA | CTD | PMID:31919559 | urethane | increases expression | ISO | RGD:1320084 | 6480464 | Urethane results in increased expression of GUK1 mRNA | CTD | PMID:28818685 | valproic acid | multiple interactions | ISO | RGD:1320084 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of GUK1 mRNA | CTD | PMID:17183730 | |