ENCODES a protein that exhibits prostaglandin binding; G protein-coupled receptor activity (ortholog); prostaglandin D receptor activity (ortholog); INVOLVED IN positive regulation of eosinophil migration; positive regulation of lymphocyte migration; positive regulation of release of sequestered cal
cium ion into cytosol; ASSOCIATED WITH allergic asthma; aspergillosis; pulmonary eosinophilia; FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH 13,14-dihydro-15-ketoprostaglandin D2; 2,3,7,8-tetrachlorodibenzodioxine; acetamide
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Si
Enables prostaglandin D receptor activity; prostaglandin F receptor activity; and prostaglandin J receptor activity. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; calcium-mediated signaling; and negative regulation
of male germ cell proliferation. Predicted to be active in neuron projection and plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR2 (prostaglandin D2 receptor 2). [provided by Alliance of Genome Resources, Apr 2025]