| 1557489 | Gmppa | GDP-mannose pyrophosphorylase A | Predicted to enable enzyme regulator activity and molecular sensor activity. Involved in negative regulation of metabolic process. Acts upstream of or within several processes, including GDP-mannose biosynthetic process; motor behavior; and protein glycosylation. Predicted to be part of GDP-mannose pyrophosphorylase complex. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; eye; and gonad. Used to study alacrima, achalasia, and impaired intellectual development syndrome. Human ortholog(s) of this gene implicated in alacrima, achalasia, and impaired intellectual development syndrome. Orthologous to human GMPPA (GDP-mannose pyrophosphorylase A). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 75412555 | 75419823 | Mouse | 148 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1560644 | Gmppa | GDP-mannose pyrophosphorylase A | ENCODES a protein that exhibits enzyme binding (ortholog); enzyme inhibitor activity (ortholog); mannose-1-phosphate guanylyltransferase (GTP) activity (ortholog); INVOLVED IN cognition (ortholog); GDP-mannose biosynthetic process (ortholog); GDP-mannose metabolic process (ortholog); PARTICIPATES IN amino sugar metabolic pathway; fructose and mannose metabolic pathway; nucleotide sugar metabolic pathway; ASSOCIATED WITH alacrima, achalasia, and impaired intellectual development syndrome (ortholog); cerebrotendinous xanthomatosis (ortholog); FOUND IN GDP-mannose pyrophosphorylase complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil | 9 | 84375373 | 84382917 | Rat | 118 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1607034 | GMPPA | GDP-mannose pyrophosphorylase A | This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides. [provided by RefSeq, Jul 2008] | 2 | 219498891 | 219506989 | Human | 182 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8868529 | Gmppa | GDP-mannose pyrophosphorylase A | ENCODES a protein that exhibits enzyme binding (ortholog); enzyme inhibitor activity (ortholog); mannose-1-phosphate guanylyltransferase (GTP) activity (ortholog); INVOLVED IN cognition (ortholog); GDP-mannose biosynthetic process (ortholog); GDP-mannose metabolic process (ortholog); ASSOCIATED WITH alacrima, achalasia, and impaired intellectual development syndrome (ortholog); cerebrotendinous xanthomatosis (ortholog); FOUND IN GDP-mannose pyrophosphorylase complex (ortholog) | NW_004955453 | 13967118 | 13974351 | Chinchilla | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11857467 | GMPPA | GDP-mannose pyrophosphorylase A | ENCODES a protein that exhibits mannose-1-phosphate guanylyltransferase (GTP) activity (ortholog); INVOLVED IN cognition (ortholog); GDP-mannose biosynthetic process (ortholog); GDP-mannose metabolic process (ortholog); ASSOCIATED WITH alacrima, achalasia, and impaired intellectual development syndr ome (ortholog); cerebrotendinous xanthomatosis (ortholog); FOUND IN cytoplasm (inferred); GDP-mannose pyrophosphorylase complex (inferred) | 2B | 106756115 | 106764280 | Bonobo | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12227777 | GMPPA | GDP-mannose pyrophosphorylase A | ENCODES a protein that exhibits mannose-1-phosphate guanylyltransferase (GTP) activity (ortholog); INVOLVED IN cognition (ortholog); GDP-mannose biosynthetic process (ortholog); GDP-mannose metabolic process (ortholog); ASSOCIATED WITH alacrima, achalasia, and impaired intellectual development syndr ome (ortholog); cerebrotendinous xanthomatosis (ortholog); FOUND IN cytoplasm (inferred); GDP-mannose pyrophosphorylase complex (inferred) | 37 | 26010531 | 26017798 | Dog | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12514570 | Gmppa | GDP-mannose pyrophosphorylase A | ENCODES a protein that exhibits mannose-1-phosphate guanylyltransferase (GTP) activity (ortholog); INVOLVED IN cognition (ortholog); GDP-mannose biosynthetic process (ortholog); GDP-mannose metabolic process (ortholog); ASSOCIATED WITH alacrima, achalasia, and impaired intellectual development syndr ome (ortholog); cerebrotendinous xanthomatosis (ortholog); FOUND IN cytoplasm (inferred); GDP-mannose pyrophosphorylase complex (inferred) | NW_004936569 | 1881975 | 1889179 | Squirrel | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234404 | gmppa | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18351386 | GMPPA | GDP-mannose pyrophosphorylase A | ENCODES a protein that exhibits mannose-1-phosphate guanylyltransferase (GTP) activity (ortholog); INVOLVED IN cognition (ortholog); GDP-mannose biosynthetic process (ortholog); GDP-mannose metabolic process (ortholog); ASSOCIATED WITH alacrima, achalasia, and impaired intellectual development syndr ome (ortholog); cerebrotendinous xanthomatosis (ortholog); FOUND IN cytoplasm (inferred); GDP-mannose pyrophosphorylase complex (inferred) | | | | Green Monkey | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13987209 | GMPPA | GDP-mannose pyrophosphorylase A | ENCODES a protein that exhibits mannose-1-phosphate guanylyltransferase (GTP) activity (ortholog); INVOLVED IN cognition (ortholog); GDP-mannose biosynthetic process (ortholog); GDP-mannose metabolic process (ortholog); ASSOCIATED WITH alacrima, achalasia, and impaired intellectual development syndr ome (ortholog); cerebrotendinous xanthomatosis (ortholog); FOUND IN GDP-mannose pyrophosphorylase complex (ortholog) | | | | Pig | 30 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 626081242 | Gmppa | GDP-mannose pyrophosphorylase A | ENCODES a protein that exhibits enzyme binding (ortholog); enzyme inhibitor activity (ortholog); mannose-1-phosphate guanylyltransferase (GTP) activity (ortholog); INVOLVED IN cognition (ortholog); GDP-mannose biosynthetic process (ortholog); GDP-mannose metabolic process (ortholog); ASSOCIATED WITH alacrima, achalasia, and impaired intellectual development syndrome (ortholog); FOUND IN GDP-mannose pyrophosphorylase complex (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18899576 | Gmppa | GDP-mannose pyrophosphorylase A | ENCODES a protein that exhibits enzyme binding (ortholog); enzyme inhibitor activity (ortholog); mannose-1-phosphate guanylyltransferase (GTP) activity (ortholog); INVOLVED IN cognition (ortholog); GDP-mannose biosynthetic process (ortholog); GDP-mannose metabolic process (ortholog); ASSOCIATED WITH alacrima, achalasia, and impaired intellectual development syndrome (ortholog); cerebrotendinous xanthomatosis (ortholog); FOUND IN GDP-mannose pyrophosphorylase complex (ortholog) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245705 | gmppa.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155234403 | gmppa.S | | | | | | African Clawed Frog | | symbol | gene, null |