| 2689 | Gipr | gastric inhibitory polypeptide receptor | ENCODES a protein that exhibits gastric inhibitory peptide receptor activity; peptide hormone binding; glucagon family peptide binding (ortholog); INVOLVED IN desensitization of G protein-coupled receptor signaling pathway; gastric inhibitory peptide signaling pathway; positive regulation of cytosol ic calcium ion concentration; ASSOCIATED WITH Experimental Diabetes Mellitus; hyperglycemia; type 2 diabetes mellitus; FOUND IN plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 1 | 87932316 | 87956084 | Rat | 107 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732777 | GIPR | gastric inhibitory polypeptide receptor | This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevate d glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011] | 19 | 45668221 | 45683722 | Human | 117 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1557958 | Gipr | gastric inhibitory polypeptide receptor | Enables gastric inhibitory peptide receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and positive regulation of insulin secretion. Acts upstream of or within endocrine pancreas development. Is active in plasma membrane. Is expressed in cortical plate; foregut-midgut junction; neck; and thyroid gland. Human ortholog(s) of this gene implicated in cardiovascular system disease; diabetes mellitus; obesity; and type 2 diabetes mellitus. Orthologous to human GIPR (gastric inhibitory polypeptide receptor). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 18889988 | 18904173 | Mouse | 135 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8763736 | Gipr | gastric inhibitory polypeptide receptor | ENCODES a protein that exhibits gastric inhibitory peptide receptor activity (ortholog); glucagon family peptide binding (ortholog); peptide hormone binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); desensitization of G protein-coup led receptor signaling pathway (ortholog); endocrine pancreas development (ortholog); ASSOCIATED WITH Body Weight (ortholog); cardiovascular system disease (ortholog); diabetes mellitus (ortholog); FOUND IN plasma membrane (ortholog) | NW_004955574 | 140307 | 153684 | Chinchilla | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11918362 | GIPR | gastric inhibitory polypeptide receptor | ENCODES a protein that exhibits gastric inhibitory peptide receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN desensitization of G protein-coupled receptor signaling pathway (ortholog); endocrine pancreas development (ortholog); gastric inhibitory peptide signaling pathway (ortholog); ASSOCIATED WITH Body Weight (ortholog); cardiovascular system disease (ortholog); diabetes mellitus (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 19 | 42673553 | 42688059 | Bonobo | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12211734 | GIPR | gastric inhibitory polypeptide receptor | ENCODES a protein that exhibits gastric inhibitory peptide receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN desensitization of G protein-coupled receptor signaling pathway (ortholog); endocrine pancreas development (ortholog); gastric inhibitory peptide signaling pathway (ortholog); ASSOCIATED WITH Body Weight (ortholog); cardiovascular system disease (ortholog); diabetes mellitus (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 1 | 109898617 | 109909331 | Dog | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12652599 | Gipr | gastric inhibitory polypeptide receptor | ENCODES a protein that exhibits gastric inhibitory peptide receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN desensitization of G protein-coupled receptor signaling pathway (ortholog); endocrine pancreas development (ortholog); gastric inhibitory peptide signaling pathway (ortholog); ASSOCIATED WITH Body Weight (ortholog); cardiovascular system disease (ortholog); diabetes mellitus (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | NW_004936706 | 2052069 | 2062722 | Squirrel | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234583 | gipr | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625949340 | Gipr | gastric inhibitory polypeptide receptor | ENCODES a protein that exhibits gastric inhibitory peptide receptor activity (ortholog); glucagon family peptide binding (ortholog); peptide hormone binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); desensitization of G protein-coup led receptor signaling pathway (ortholog); endocrine pancreas development (ortholog); ASSOCIATED WITH Body Weight (ortholog); cardiovascular system disease (ortholog); diabetes mellitus (ortholog); FOUND IN plasma membrane (ortholog) | | | | Black Rat | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18474880 | GIPR | gastric inhibitory polypeptide receptor | ENCODES a protein that exhibits gastric inhibitory peptide receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN desensitization of G protein-coupled receptor signaling pathway (ortholog); endocrine pancreas development (ortholog); gastric inhibitory peptide signaling pathway (ortholog); ASSOCIATED WITH Body Weight (ortholog); cardiovascular system disease (ortholog); diabetes mellitus (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18920943 | Gipr | gastric inhibitory polypeptide receptor | ENCODES a protein that exhibits gastric inhibitory peptide receptor activity (ortholog); glucagon family peptide binding (ortholog); peptide hormone binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); desensitization of G protein-coup led receptor signaling pathway (ortholog); endocrine pancreas development (ortholog); ASSOCIATED WITH Body Weight (ortholog); cardiovascular system disease (ortholog); diabetes mellitus (ortholog); FOUND IN plasma membrane (ortholog) | | | | Naked Mole-Rat | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14186569 | GIPR | gastric inhibitory polypeptide receptor | ENCODES a protein that exhibits gastric inhibitory peptide receptor activity (ortholog); peptide hormone binding (ortholog); INVOLVED IN desensitization of G protein-coupled receptor signaling pathway (ortholog); endocrine pancreas development (ortholog); gastric inhibitory peptide signaling pathway (ortholog); ASSOCIATED WITH Body Weight (ortholog); cardiovascular system disease (ortholog); diabetes mellitus (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234582 | gipr.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155235289 | gipr.S | | | | | | African Clawed Frog | | symbol | gene, null |