| 1309069 | Fyco1 | FYVE and coiled-coil domain autophagy adaptor 1 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN plus-end-directed vesicle transport along microtubule (ortholog); positive regulation of autophagosome maturation (ortholog); ASSOCIATED WITH cataract (ortholog); cataract 18 (ortholog); Eye Abnorm alities (ortholog); FOUND IN autophagosome (ortholog); late endosome (ortholog); lysosome (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; aflatoxin B1 | 8 | 132289538 | 132356810 | Rat | 110 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1319203 | FYCO1 | FYVE and coiled-coil domain autophagy adaptor 1 | The gene encodes a Rab7 adapter protein that is implicated in the microtubule transport of autophagosomes. The encoded protein contains a RUN domain, a FYVE-type zinc finger domain, and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autop hagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P), the autophagosome marker LC3, and the kinesin KIF5. Mutations in this gene are associated with inclusion body myositis (IBM) and autosomal recessive congenital cataracts (CATC2). [provided by RefSeq, Aug 2020] | 3 | 45917903 | 45995824 | Human | 142 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1319204 | Fyco1 | FYVE and coiled-coil domain containing 1 | Predicted to enable zinc ion binding activity. Predicted to be involved in plus-end-directed vesicle transport along microtubule and positive regulation of autophagosome maturation. Predicted to be located in Golgi apparatus. Predicted to be active in autophagosome; late endosome; and lysosome. Is e xpressed in central nervous system; early conceptus; and retina. Human ortholog(s) of this gene implicated in cataract 18. Orthologous to human FYCO1 (FYVE and coiled-coil domain autophagy adaptor 1). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 123618565 | 123681110 | Mouse | 131 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8944985 | Fyco1 | FYVE and coiled-coil domain autophagy adaptor 1 | INVOLVED IN plus-end-directed vesicle transport along microtubule (ortholog); positive regulation of autophagosome maturation (ortholog); ASSOCIATED WITH cataract (ortholog); cataract 18 (ortholog); Eye Abnormalities (ortholog); FOUND IN autophagosome (ortholog); late endosome (ortholog); lysosome ( ortholog) | NW_004955420 | 26019621 | 26076846 | Chinchilla | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11903172 | FYCO1 | FYVE and coiled-coil domain autophagy adaptor 1 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN plus-end-directed vesicle transport along microtubule (inferred); positive regulation of autophagosome maturation (inferred); ASSOCIATED WITH cataract (ortholog); cataract 18 (ortholog); Eye Abnorm alities (ortholog); FOUND IN autophagosome (inferred); cytoplasmic vesicle (inferred); endosome (inferred) | 3 | 45825670 | 45903595 | Bonobo | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12081481 | FYCO1 | FYVE and coiled-coil domain autophagy adaptor 1 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN plus-end-directed vesicle transport along microtubule (inferred); positive regulation of autophagosome maturation (inferred); ASSOCIATED WITH cataract (ortholog); cataract 18 (ortholog); Eye Abnorm alities (ortholog); FOUND IN autophagosome (inferred); cytoplasmic vesicle (inferred); endosome (inferred) | 20 | 42520241 | 42593886 | Dog | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12493574 | Fyco1 | FYVE and coiled-coil domain autophagy adaptor 1 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN plus-end-directed vesicle transport along microtubule (inferred); positive regulation of autophagosome maturation (inferred); ASSOCIATED WITH cataract (ortholog); cataract 18 (ortholog); Eye Abnorm alities (ortholog); FOUND IN autophagosome (inferred); cytoplasmic vesicle (inferred); endosome (inferred) | NW_004936596 | 3938 | 81226 | Squirrel | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13846145 | FYCO1 | FYVE and coiled-coil domain autophagy adaptor 1 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); ASSOCIATED WITH cataract (ortholog); cataract 18 (ortholog); Eye Abnormalities (ortholog); FOUND IN late endosome (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 26 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 625964503 | Fyco1 | FYVE and coiled-coil domain autophagy adaptor 1 | INVOLVED IN plus-end-directed vesicle transport along microtubule (ortholog); positive regulation of autophagosome maturation (ortholog); ASSOCIATED WITH cataract (ortholog); cataract 18 (ortholog); Eye Abnormalities (ortholog); FOUND IN autophagosome (ortholog); late endosome (ortholog); lysosome ( ortholog) | | | | Black Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18917463 | Fyco1 | FYVE and coiled-coil domain autophagy adaptor 1 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN plus-end-directed vesicle transport along microtubule (inferred); positive regulation of autophagosome maturation (inferred); ASSOCIATED WITH cataract (ortholog); cataract 18 (ortholog); Eye Abnorm alities (ortholog); FOUND IN autophagosome (inferred); cytoplasmic vesicle (inferred); endosome (inferred) | | | | Naked Mole-Rat | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18496271 | FYCO1 | FYVE and coiled-coil domain autophagy adaptor 1 | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN plus-end-directed vesicle transport along microtubule (inferred); positive regulation of autophagosome maturation (inferred); ASSOCIATED WITH cataract (ortholog); cataract 18 (ortholog); Eye Abnorm alities (ortholog); FOUND IN autophagosome (inferred); cytoplasmic vesicle (inferred); endosome (inferred) | | | | Green Monkey | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |