| 2173 | Fxyd2 | FXYD domain-containing ion transport regulator 2 | ENCODES a protein that exhibits ATPase activator activity (ortholog); protein-macromolecule adaptor activity (ortholog); sodium channel regulator activity (ortholog); INVOLVED IN cellular hyperosmotic salinity response; monoatomic cation transport; negative regulation of cell population proliferatio n; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); hypertension (ortholog); primary hypomagnesemia (ortholog); FOUND IN basolateral plasma membrane; sodium:potassium-exchanging ATPase complex; membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine | 8 | 54609658 | 54616788 | Rat | 242 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 736423 | Fxyd2 | FXYD domain-containing ion transport regulator 2 | This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion t ransport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Multiple transcript variants have been described for this gene that are expressed in tissue-specific and developmental stage-specific patterns and encode proteins that differ at the N-terminus. [provided by RefSeq, Sep 2009] | 9 | 45311007 | 45321576 | Mouse | 254 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1342669 | FXYD2 | FXYD domain containing ion transport regulator 2 | This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Rea d-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011] | 11 | 117820057 | 117828089 | Human | 256 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8959072 | Fxyd2 | FXYD domain containing ion transport regulator 2 | ENCODES a protein that exhibits ATPase activator activity (ortholog); protein-macromolecule adaptor activity (ortholog); sodium channel regulator activity (ortholog); INVOLVED IN cellular hyperosmotic salinity response (ortholog); intracellular potassium ion homeostasis (ortholog); intracellular sod ium ion homeostasis (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); hypertension (ortholog); primary hypomagnesemia (ortholog); FOUND IN basolateral plasma membrane (ortholog); membrane (ortholog); sodium:potassium-exchanging ATPase complex (ortholog) | NW_004955412 | 19039635 | 19046172 | Chinchilla | 121 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11877813 | FXYD2 | FXYD domain containing ion transport regulator 2 | ENCODES a protein that exhibits ATPase activator activity (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN cellular hyperosmotic salinity response (ortholog); intracellular potassium ion homeostasis (ortholog); intracellular sodium ion homeostasis (ortholog); PARTICIPATES I N acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); hypertension (ortholog); primary hypomagnesemia (ortholog); FOUND IN basolateral plasma membrane (ortholog); sodium:potassium-exchanging ATPase complex (ortholog) | 11 | 112654774 | 112666630 | Bonobo | 129 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12232975 | FXYD2 | FXYD domain containing ion transport regulator 2 | ENCODES a protein that exhibits ATPase activator activity (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN cellular hyperosmotic salinity response (ortholog); intracellular potassium ion homeostasis (ortholog); intracellular sodium ion homeostasis (ortholog); PARTICIPATES I N acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); hypertension (ortholog); primary hypomagnesemia (ortholog); FOUND IN basolateral plasma membrane (ortholog); sodium:potassium-exchanging ATPase complex (ortholog) | 5 | 15812335 | 15824552 | Dog | 128 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12439125 | Fxyd2 | FXYD domain containing ion transport regulator 2 | ENCODES a protein that exhibits ATPase activator activity (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN cellular hyperosmotic salinity response (ortholog); intracellular potassium ion homeostasis (ortholog); intracellular sodium ion homeostasis (ortholog); PARTICIPATES I N acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); hypertension (ortholog); primary hypomagnesemia (ortholog); FOUND IN basolateral plasma membrane (ortholog); sodium:potassium-exchanging ATPase complex (ortholog) | NW_004936542 | 2956784 | 2961076 | Squirrel | 129 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626123114 | Fxyd2 | FXYD domain containing ion transport regulator 2 | ENCODES a protein that exhibits ATPase activator activity (ortholog); protein-macromolecule adaptor activity (ortholog); sodium channel regulator activity (ortholog); INVOLVED IN cellular hyperosmotic salinity response (ortholog); intracellular potassium ion homeostasis (ortholog); intracellular sod ium ion homeostasis (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); hypertension (ortholog); primary hypomagnesemia (ortholog); FOUND IN basolateral plasma membrane (ortholog); membrane (ortholog); sodium:potassium-exchanging ATPase complex (ortholog) | | | | Black Rat | 121 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18731647 | FXYD2 | FXYD domain containing ion transport regulator 2 | ENCODES a protein that exhibits ATPase activator activity (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN cellular hyperosmotic salinity response (ortholog); intracellular potassium ion homeostasis (ortholog); intracellular sodium ion homeostasis (ortholog); PARTICIPATES I N acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); hypertension (ortholog); primary hypomagnesemia (ortholog); FOUND IN basolateral plasma membrane (ortholog); sodium:potassium-exchanging ATPase complex (ortholog) | | | | Green Monkey | 129 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18924808 | Fxyd2 | FXYD domain containing ion transport regulator 2 | ENCODES a protein that exhibits ATPase activator activity (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN cellular hyperosmotic salinity response (ortholog); intracellular potassium ion homeostasis (ortholog); intracellular sodium ion homeostasis (ortholog); PARTICIPATES I N acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); hypertension (ortholog); primary hypomagnesemia (ortholog); FOUND IN basolateral plasma membrane (ortholog); sodium:potassium-exchanging ATPase complex (ortholog) | | | | Naked Mole-Rat | 129 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254975 | fxyd2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14229788 | FXYD2 | FXYD domain containing ion transport regulator 2 | ENCODES a protein that exhibits ATPase activator activity; protein-macromolecule adaptor activity; sodium channel regulator activity (ortholog); INVOLVED IN intracellular potassium ion homeostasis; intracellular sodium ion homeostasis; potassium ion import across plasma membrane; PARTICIPATES IN ace butolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); hypertension (ortholog); primary hypomagnesemia (ortholog); FOUND IN sodium:potassium-exchanging ATPase complex; basolateral plasma membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 131 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155254813 | fxyd2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155249899 | fxyd2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6766909 | FXYD6-FXYD2 | FXYD6-FXYD2 readthrough | This locus represents naturally occurring read-through transcription between the neighboring FXYD domain-containing ion transport regulator 6 (GeneID 53826) and sodium/potassium-transporting ATPase subunit gamma (GeneID 486) genes on chromosome 11. One read-through transcript produces a fusion prote in that shares sequence identity with each individual gene product, while another read-through transcript encodes a protein that has a distinct C-terminus and only shares sequence identity with the upstream locus (GeneID 53826). [provided by RefSeq, Aug 2011] | 11 | 117820057 | 117876658 | Human | 9 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 288061956 | XB22063245 [provisional:fxyd2] | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 288083068 | XB22063245.L [provisional:fxyd2] | | | | | | African Clawed Frog | | symbol | gene, null |
| 288061934 | XB22063245.S [provisional:fxyd2] | | | | | | African Clawed Frog | | symbol | gene, null |
| 16560457 | AP000757.2 | novel transcript, antisense to FXYD2 | | | | | Human | | name | gene, lncrna |
| 734187 | FXYD1 | FXYD domain containing ion transport regulator 1 | This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion t ransport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature. [provided by RefSeq, Jul 2008] | 19 | 35137188 | 35143109 | Human | 172 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 735875 | Fxyd4 | FXYD domain-containing ion transport regulator 4 | This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion t ransport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. [provided by RefSeq, Jul 2008] | 6 | 117910519 | 117914668 | Mouse | 95 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1605677 | FXYD5 | FXYD domain containing ion transport regulator 5 | This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion t ransport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009] | 19 | 35154735 | 35169881 | Human | 149 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 735926 | Fxyd6 | FXYD domain-containing ion transport regulator 6 | This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, Fxyd6, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Jul 2006] | 9 | 45280768 | 45307457 | Mouse | 114 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 732780 | FXYD7 | FXYD domain containing ion transport regulator 7 | This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000] | 19 | 35143255 | 35154302 | Human | 83 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 737495 | Fxyd7 | FXYD domain-containing ion transport regulator 7 | This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000] | 7 | 30741940 | 30750879 | Mouse | 82 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 735874 | FXYD4 | FXYD domain containing ion transport regulator 4 | This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion t ransport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, May 2010] | 10 | 43371636 | 43376335 | Human | 89 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 735925 | FXYD6 | FXYD domain containing ion transport regulator 6 | This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011] | 11 | 117836981 | 117877430 | Human | 118 | description | gene, protein-coding, REVIEWED [RefSeq] |
