Fxyd2 (FXYD domain containing ion transport regulator 2) - Rat Genome Database

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Gene: Fxyd2 (FXYD domain containing ion transport regulator 2) Ictidomys tridecemlineatus
Analyze
Symbol: Fxyd2
Name: FXYD domain containing ion transport regulator 2
RGD ID: 12439125
Description: ENCODES a protein that exhibits ATPase activator activity (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN cellular hyperosmotic salinity response (ortholog); inorganic cation transmembrane transport (ortholog); intracellular potassium ion homeostasis (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH CD3epsilon deficiency (ortholog); chromosome 11 partial duplication syndrome (ortholog); Dwarfism (ortholog); FOUND IN basolateral plasma membrane (ortholog); sodium:potassium-exchanging ATPase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium/potassium-transporting ATPase subunit gamma
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947100,035,374 - 100,039,684 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,956,785 - 2,963,506 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365422,956,784 - 2,961,076 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Fxyd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947100,035,374 - 100,039,684 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,956,785 - 2,963,506 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365422,956,784 - 2,961,076 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FXYD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811117,820,057 - 117,828,089 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11117,800,844 - 117,828,698 (-)EnsemblGRCh38hg38GRCh38
GRCh3711117,690,772 - 117,698,804 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611117,196,000 - 117,204,017 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411117,195,999 - 117,204,017NCBI
Celera11114,848,637 - 114,856,650 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11113,624,622 - 113,632,639 (-)NCBIHuRef
CHM1_111117,576,366 - 117,584,383 (-)NCBICHM1_1
T2T-CHM13v2.011117,836,469 - 117,844,497 (-)NCBIT2T-CHM13v2.0
Fxyd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39945,311,007 - 45,321,576 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl945,310,967 - 45,321,576 (+)EnsemblGRCm39 Ensembl
GRCm38945,399,709 - 45,410,278 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl945,399,669 - 45,410,278 (+)EnsemblGRCm38mm10GRCm38
MGSCv37945,207,792 - 45,218,361 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36945,150,213 - 45,161,273 (+)NCBIMGSCv36mm8
Celera942,679,863 - 42,690,444 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map924.84NCBI
Fxyd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8854,609,658 - 54,616,788 (+)NCBIGRCr8
mRatBN7.2845,712,901 - 45,720,032 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl845,712,903 - 45,720,203 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx851,214,299 - 51,220,774 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0849,493,069 - 49,499,544 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0847,357,158 - 47,363,642 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0849,710,334 - 49,717,492 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl849,710,477 - 49,716,955 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0848,336,046 - 48,343,177 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4848,379,075 - 48,385,553 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1848,387,840 - 48,394,319 (+)NCBI
Celera845,295,931 - 45,302,409 (+)NCBICelera
Cytogenetic Map8q22NCBI
Fxyd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541219,039,635 - 19,046,159 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541219,039,635 - 19,046,172 (-)NCBIChiLan1.0ChiLan1.0
FXYD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29118,521,067 - 118,537,885 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111119,626,001 - 119,642,808 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011112,654,774 - 112,666,630 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111116,587,226 - 116,598,684 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11116,587,226 - 116,595,197 (-)Ensemblpanpan1.1panPan2
FXYD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1515,812,335 - 15,824,552 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl515,815,969 - 15,823,057 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha515,865,958 - 15,873,046 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0515,753,844 - 15,766,049 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl515,757,465 - 15,764,547 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1515,895,521 - 15,902,609 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0515,798,806 - 15,805,894 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0515,840,422 - 15,847,514 (+)NCBIUU_Cfam_GSD_1.0
FXYD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1945,165,314 - 45,172,440 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2950,244,542 - 50,252,397 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FXYD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11109,187,301 - 109,199,729 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1109,186,886 - 109,198,267 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604316,860,199 - 16,864,880 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fxyd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478413,200,018 - 13,206,131 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478413,198,308 - 13,209,780 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005328314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000028588   ⟹   ENSSTOP00000015976
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365422,956,785 - 2,963,506 (-)Ensembl
RefSeq Acc Id: XM_005328314   ⟹   XP_005328371
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947100,035,374 - 100,039,684 (-)NCBI
SpeTri2.0NW_0049365422,956,784 - 2,961,076 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005328371 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000015976.2
RefSeq Acc Id: XP_005328371   ⟸   XM_005328314
- Sequence:
Ensembl Acc Id: ENSSTOP00000015976   ⟸   ENSSTOT00000028588


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000028766 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000028588.2 UniProtKB/TrEMBL
Gene3D-CATH Single helix bin UniProtKB/TrEMBL
InterPro ATNG UniProtKB/TrEMBL
  FXYD_motif UniProtKB/TrEMBL
  Ion-transport_regulator_FXYD UniProtKB/TrEMBL
NCBI Gene Fxyd2 ENTREZGENE
PANTHER SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA UniProtKB/TrEMBL
  SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA UniProtKB/TrEMBL
Pfam ATP1G1_PLM_MAT8 UniProtKB/TrEMBL
PROSITE FXYD UniProtKB/TrEMBL
UniProt I3MV31_ICTTR UniProtKB/TrEMBL