| 735156 | Fgfrl1 | fibroblast growth factor receptor-like 1 | ENCODES a protein that exhibits fibroblast growth factor binding (ortholog); fibroblast growth factor receptor activity (ortholog); heparin binding (ortholog); INVOLVED IN cell-cell adhesion (ortholog); diaphragm development (ortholog); heart valve morphogenesis (ortholog); ASSOCIATED WITH congenita l diaphragmatic hernia (ortholog); Contracture (ortholog); COVID-19 (ortholog); FOUND IN cell-cell contact zone (ortholog); Golgi apparatus (ortholog); plasma membrane (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 14 | 1154275 | 1166334 | Rat | 132 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1354107 | FGFRL1 | fibroblast growth factor receptor like 1 | The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length r epresentative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008] | 4 | 1010212 | 1026898 | Human | 217 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1552790 | Fgfrl1 | fibroblast growth factor receptor-like 1 | Enables fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Acts upstream of or within several processes, including diaphragm development; heart development; and skeletal system development. Located in plasma membrane. Is expressed in several structures, includi ng alimentary system; brain; musculoskeletal system; respiratory system; and sensory organ. Used to study Wolf-Hirschhorn syndrome. Orthologous to human FGFRL1 (fibroblast growth factor receptor like 1). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 108842051 | 108854816 | Mouse | 212 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9026866 | Fgfrl1 | fibroblast growth factor receptor like 1 | ENCODES a protein that exhibits fibroblast growth factor binding (ortholog); fibroblast growth factor receptor activity (ortholog); heparin binding (ortholog); INVOLVED IN cell-cell adhesion (ortholog); diaphragm development (ortholog); heart valve morphogenesis (ortholog); ASSOCIATED WITH congenita l diaphragmatic hernia (ortholog); Contracture (ortholog); COVID-19 (ortholog); FOUND IN cell-cell contact zone (ortholog); Golgi apparatus (ortholog); plasma membrane (ortholog) | NW_004955514 | 499526 | 509208 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11900106 | FGFRL1 | fibroblast growth factor receptor like 1 | ENCODES a protein that exhibits fibroblast growth factor binding (inferred); fibroblast growth factor receptor activity (inferred); heparin binding (inferred); INVOLVED IN diaphragm development (ortholog); heart valve morphogenesis (ortholog); negative regulation of cell population proliferation (or tholog); ASSOCIATED WITH congenital diaphragmatic hernia (ortholog); Contracture (ortholog); COVID-19 (ortholog); FOUND IN cell-cell contact zone (inferred); Golgi apparatus (inferred); membrane (inferred) | 4 | 1125623 | 1142884 | Bonobo | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12149011 | FGFRL1 | fibroblast growth factor receptor like 1 | ENCODES a protein that exhibits fibroblast growth factor binding (inferred); fibroblast growth factor receptor activity (inferred); heparin binding (inferred); INVOLVED IN diaphragm development (ortholog); heart valve morphogenesis (ortholog); negative regulation of cell population proliferation (or tholog); ASSOCIATED WITH congenital diaphragmatic hernia (ortholog); Contracture (ortholog); COVID-19 (ortholog); FOUND IN cell-cell contact zone (inferred); Golgi apparatus (inferred); membrane (inferred) | 3 | 91499088 | 91508982 | Dog | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12709203 | Fgfrl1 | fibroblast growth factor receptor like 1 | ENCODES a protein that exhibits fibroblast growth factor binding (inferred); fibroblast growth factor receptor activity (inferred); heparin binding (inferred); INVOLVED IN diaphragm development (ortholog); heart valve morphogenesis (ortholog); negative regulation of cell population proliferation (or tholog); ASSOCIATED WITH congenital diaphragmatic hernia (ortholog); Contracture (ortholog); COVID-19 (ortholog); FOUND IN cell-cell contact zone (inferred); Golgi apparatus (inferred); membrane (inferred) | NW_004936477 | 22177473 | 22189554 | Squirrel | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255439 | fgfrl1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13858274 | FGFRL1 | fibroblast growth factor receptor like 1 | ENCODES a protein that exhibits fibroblast growth factor binding (inferred); fibroblast growth factor receptor activity (inferred); heparin binding (inferred); INVOLVED IN diaphragm development (ortholog); heart valve morphogenesis (ortholog); negative regulation of cell population proliferation (or tholog); ASSOCIATED WITH congenital diaphragmatic hernia (ortholog); Contracture (ortholog); COVID-19 (ortholog); FOUND IN cell-cell contact zone (inferred); Golgi apparatus (inferred); membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626099812 | Fgfrl1 | fibroblast growth factor receptor like 1 | ENCODES a protein that exhibits fibroblast growth factor binding (ortholog); fibroblast growth factor receptor activity (ortholog); heparin binding (ortholog); INVOLVED IN cell-cell adhesion (ortholog); diaphragm development (ortholog); heart valve morphogenesis (ortholog); ASSOCIATED WITH congenita l diaphragmatic hernia (ortholog); Contracture (ortholog); COVID-19 (ortholog); FOUND IN cell-cell contact zone (ortholog); Golgi apparatus (ortholog); plasma membrane (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18558218 | FGFRL1 | fibroblast growth factor receptor like 1 | ENCODES a protein that exhibits fibroblast growth factor binding (inferred); fibroblast growth factor receptor activity (inferred); heparin binding (inferred); INVOLVED IN diaphragm development (ortholog); heart valve morphogenesis (ortholog); negative regulation of cell population proliferation (or tholog); ASSOCIATED WITH congenital diaphragmatic hernia (ortholog); Contracture (ortholog); COVID-19 (ortholog); FOUND IN cell-cell contact zone (inferred); Golgi apparatus (inferred); membrane (inferred) | | | | Green Monkey | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 19259629 | FGFRL1 | fibroblast growth factor receptor like 1 | | | | | Dog | | symbol | gene, protein-coding |
| 18934003 | Fgfrl1 | fibroblast growth factor receptor like 1 | ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); INVOLVED IN cell-cell adhesion (ortholog); diaphragm development (ortholog); heart valve morphogenesis (ortholog); ASSOCIATED WITH congenital diaphragmatic hernia (ortholog); Contracture (ortholog); COV ID-19 (ortholog); FOUND IN cell-cell contact zone (ortholog); Golgi apparatus (ortholog); transport vesicle (ortholog) | | | | Naked Mole-Rat | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247152 | fgfrl1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259516 | fgfrl1.S | | | | | | African Clawed Frog | | symbol | gene, null |