| 1558609 | Fezf1 | Fez family zinc finger 1 | Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell dedifferentiation; regulation of DNA-templated transcription; and regulation of neurogene sis. Acts upstream of or within nervous system development and positive regulation of neuron differentiation. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including brain and nose. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 22 with or without anosmia. Orthologous to human FEZF1 (FEZ family zinc finger 1). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 23245043 | 23250942 | Mouse | 90 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1560480 | Fezf1 | Fez family zinc finger 1 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN axon guidance (ortholog); cell dedifferentiatio n (ortholog); forebrain anterior/posterior pattern specification (ortholog); ASSOCIATED WITH amenorrhea (ortholog); genetic disease (ortholog); hypogonadotropic hypogonadism 22 with or without anosmia (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; acrylamide; bisphenol A | 4 | 52728385 | 52733315 | Rat | 74 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1604689 | FEZF1 | FEZ family zinc finger 1 | This gene encodes a transcriptional repressor that belongs to the zinc finger double domain protein family. The encoded protein is thought to play a role in the embryonic migration of gonadotropin-releasing hormone neurons into the brain. Mutations in this gene are associated with hypogonadotropic h ypogonadism-22 with anosmia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] | 7 | 122301303 | 122310723 | Human | 118 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9065904 | Fezf1 | FEZ family zinc finger 1 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN axon guidance (ortholog); cell dedifferentiatio n (ortholog); forebrain anterior/posterior pattern specification (ortholog); ASSOCIATED WITH amenorrhea (ortholog); genetic disease (ortholog); hypogonadotropic hypogonadism 22 with or without anosmia (ortholog); FOUND IN nucleoplasm (ortholog) | NW_004955479 | 3945358 | 3953924 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11771383 | FEZF1 | FEZ family zinc finger 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN axon guidance (ortholog); forebrain anterior/posterior pattern sp ecification (ortholog); forebrain development (ortholog); ASSOCIATED WITH amenorrhea (ortholog); genetic disease (ortholog); hypogonadotropic hypogonadism 22 with or without anosmia (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | 7 | 114311563 | 114322490 | Bonobo | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12556353 | Fezf1 | FEZ family zinc finger 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN axon guidance (ortholog); forebrain anterior/posterior pattern sp ecification (ortholog); forebrain development (ortholog); ASSOCIATED WITH amenorrhea (ortholog); genetic disease (ortholog); hypogonadotropic hypogonadism 22 with or without anosmia (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | NW_004936605 | 3027138 | 3030442 | Squirrel | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 40915012 | FEZF1 | FEZ family zinc finger 1 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN axon guidance (ortholog); cell dedifferentiatio n (ortholog); forebrain anterior/posterior pattern specification (ortholog); ASSOCIATED WITH amenorrhea (ortholog); genetic disease (ortholog); hypogonadotropic hypogonadism 22 with or without anosmia (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Dog | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236719 | fezf1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18910538 | Fezf1 | FEZ family zinc finger 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN axon guidance (ortholog); forebrain anterior/posterior pattern sp ecification (ortholog); forebrain development (ortholog); ASSOCIATED WITH amenorrhea (ortholog); genetic disease (ortholog); hypogonadotropic hypogonadism 22 with or without anosmia (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14037973 | FEZF1 | FEZ family zinc finger 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); metal ion binding (inferred); INVOLVED IN axon guidance (ortholog); forebrain anterior/posterior pattern specification (ortholog); forebrain development (ortho log); ASSOCIATED WITH amenorrhea (ortholog); genetic disease (ortholog); hypogonadotropic hypogonadism 22 with or without anosmia (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18732264 | FEZF1 | FEZ family zinc finger 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN axon guidance (ortholog); forebrain anterior/posterior pattern sp ecification (ortholog); forebrain development (ortholog); ASSOCIATED WITH amenorrhea (ortholog); genetic disease (ortholog); hypogonadotropic hypogonadism 22 with or without anosmia (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626045948 | Fezf1 | FEZ family zinc finger 1 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN axon guidance (ortholog); cell dedifferentiatio n (ortholog); forebrain anterior/posterior pattern specification (ortholog); ASSOCIATED WITH amenorrhea (ortholog); genetic disease (ortholog); hypogonadotropic hypogonadism 22 with or without anosmia (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236718 | fezf1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241796 | fezf1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6770016 | FEZF1-AS1 | FEZF1 antisense RNA 1 | | 7 | 122303658 | 122310077 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |