| 1604549 | FCRL3 | Fc receptor like 3 | This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmi c domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] | 1 | 157676481 | 157700956 | Human | 37 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 11686584 | FCRL3 | Fc receptor like 3 | ENCODES a protein that exhibits kinase binding (inferred); phosphatase binding (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cell surface receptor signaling pathway (inferred); immune response (inferred); negative regulation of B cell receptor signaling pathway (infer red); ASSOCIATED WITH autoimmune thyroiditis (ortholog); Graves' disease (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); plasma membrane (inferred) | 1 | 133038100 | 133062467 | Bonobo | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12190912 | FCRL3 | Fc receptor like 3 | ENCODES a protein that exhibits kinase binding (ortholog); phosphatase binding (ortholog); INVOLVED IN negative regulation of B cell receptor signaling pathway (ortholog); negative regulation of immunoglobulin production (ortholog); positive regulation of B cell proliferation (ortholog); ASSOCIATED WITH autoimmune thyroiditis (ortholog); Graves' disease (ortholog); FOUND IN cell surface (ortholog) | 7 | 40599319 | 40625939 | Dog | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18358399 | FCRL3 | Fc receptor like 3 | ENCODES a protein that exhibits kinase binding (inferred); phosphatase binding (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cell surface receptor signaling pathway (inferred); immune response (inferred); negative regulation of B cell receptor signaling pathway (infer red); ASSOCIATED WITH autoimmune thyroiditis (ortholog); Graves' disease (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155260201 | fcrl3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 597621571 | FCRL3-AS1 | FCRL3 antisense RNA 1 | | 1 | 157695429 | 157696644 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 155256482 | XB5897201 [provisional:fcrl3] | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 284926565 | XB5991222 [provisional:fcrl3] | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155256481 | XB5897201.L [provisional:fcrl3] | | | | | | African Clawed Frog | | symbol | gene, null |
| 1550776 | Fcgr4 | Fc receptor, IgG, low affinity IV | Enables IgE receptor activity and IgG receptor activity. Involved in several processes, including Fc receptor-mediated immune complex endocytosis; neutrophil activation; and positive regulation of bone resorption. Acts upstream of or within T cell mediated cytotoxicity; granzyme-mediated programmed cell death signaling pathway; and protein transport. Located in cell surface and plasma membrane. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); glomerulonephritis (multiple); graft-versus-host disease; and hematologic cancer (multiple). Orthologous to human FCGR3A (Fc gamma receptor IIIa) and FCGR3B (Fc gamma receptor IIIb). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 170846495 | 170857330 | Mouse | 215 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1589379 | Fcrl5 | Fc receptor-like 5 | ENCODES a protein that exhibits coreceptor activity (ortholog); INVOLVED IN B cell activation (ortholog); negative regulation of B cell receptor signaling pathway (ortholog); negative regulation of release of sequestered calcium ion into cytosol (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN cell surface (ortholog); plasma membrane (ortholog); receptor complex (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 175179630 | 175211180 | Rat | 49 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 13977574 | LOC100158069 | Fc receptor-like protein 3 | ENCODES a protein that exhibits kinase binding (inferred); phosphatase binding (inferred); INVOLVED IN negative regulation of B cell receptor signaling pathway (inferred); negative regulation of immunoglobulin production (inferred); positive regulation of B cell proliferation (inferred); ASSOCIATED WITH autoimmune thyroiditis (ortholog); Graves' disease (ortholog); FOUND IN cell surface (inferred); plasma membrane (inferred) | | | | Pig | 20 | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 8714139 | LOC102017650 | Fc receptor-like protein 3 | | NW_004955468 | 9539939 | 9611259 | Chinchilla | | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
