| 1558178 | Fbxo44 | F-box protein 44 | Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to act upstream of or within proteasomal protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in brain; gut; and male reproductive gland or organ. Orthologous to human FBXO44 (F-box protein 44). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 148237256 | 148244663 | Mouse | 68 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1562463 | Fbxo44 | F-box protein 44 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH polycystic ovary syndrome (ortholog); Prostatic Neo plasms (ortholog); FOUND IN nucleus (ortholog); SCF ubiquitin ligase complex (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-Tetrachlorodibenzofuran; acetamide | 5 | 163866517 | 163875928 | Rat | 67 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1606989 | FBXO44 | F-box protein 44 | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependen t ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Several alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Feb 2015] | 1 | 11654407 | 11663327 | Human | 68 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8993649 | Fbxo44 | F-box protein 44 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH polycystic ovary syndrome (ortholog); Prostatic Neo plasms (ortholog); FOUND IN nucleus (ortholog); SCF ubiquitin ligase complex (ortholog) | NW_004955486 | 2204470 | 2210604 | Chinchilla | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12243206 | FBXO44 | F-box protein 44 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (inferred); INVOLVED IN proteasomal protein catabolic process (ortholog); ASSOCIATED WITH polycystic ovary syndrome (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); SCF ubiq uitin ligase complex (inferred) | 2 | 84557468 | 84562578 | Dog | 19 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12631773 | Fbxo44 | F-box protein 44 | ENCODES a protein that exhibits carbohydrate binding (inferred); ubiquitin protein ligase activity (inferred); ubiquitin-like ligase-substrate adaptor activity (inferred); INVOLVED IN proteasomal protein catabolic process (ortholog); ASSOCIATED WITH polycystic ovary syndrome (ortholog); Prostatic Ne oplasms (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); SCF ubiquitin ligase complex (inferred) | NW_004936474 | 526191 | 531825 | Squirrel | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626180670 | fbxo44 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13920511 | FBXO44 | F-box protein 44 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH polycystic ovary syndrome (ortholog); Prostatic Neo plasms (ortholog); FOUND IN nucleus (ortholog) | | | | Pig | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18396672 | FBXO44 | F-box protein 44 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH polycystic ovary syndrome (ortholog); Prostatic Neo plasms (ortholog); FOUND IN nucleus (ortholog) | | | | Green Monkey | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626176359 | fbxo44 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 329330687 | FBXO44 | F-box protein 44 | ENCODES a protein that exhibits ubiquitin protein ligase activity (inferred); ubiquitin-like ligase-substrate adaptor activity (inferred); INVOLVED IN proteasomal protein catabolic process (ortholog); ASSOCIATED WITH polycystic ovary syndrome (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cyto plasm (inferred); nucleus (inferred); SCF ubiquitin ligase complex (inferred) | | | | Bonobo | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626185180 | fbxo44 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626182495 | fbxo44 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626177886 | fbxo44 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 11672353 | FBXO6 | F-box protein 6 | ENCODES a protein that exhibits carbohydrate binding (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN ERAD pathway (inferred); glycoprotein catabolic process (inferred); SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH Stevens-J ohnson syndrome (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum quality control compartment (inferred); SCF ubiquitin ligase complex (inferred) | 1 | 10414856 | 10436406 | Bonobo | 23 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18913989 | LOC101722747 | F-box only protein 44 | ENCODES a protein that exhibits carbohydrate binding (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN ERAD pathway (inferred); glycoprotein catabolic process (inferred); SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (inferred); FOUND IN cytoplasm (infer red); SCF ubiquitin ligase complex (inferred) | | | | Naked Mole-Rat | 12 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |