| 620373 | Fbxo32 | F-box protein 32 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN muscle atrophy; negative regulation of cardiac muscle hypertrophy; positive regulation of cardiac muscle cell apoptotic process; ASSOCIATED WITH muscular atrophy; atrial fibrillation (ortholog); primary pulmonary hypertension (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl | 7 | 91620925 | 91654491 | Rat | 273 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 734419 | FBXO32 | F-box protein 32 | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependen t ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] | 8 | 123497889 | 123541206 | Human | 267 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 737552 | Fbxo32 | F-box protein 32 | Involved in response to denervation involved in regulation of muscle adaptation. Acts upstream of or within cellular response to dexamethasone stimulus. Located in Z disc and nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; male reproductive gl and or organ; and sensory organ. Orthologous to human FBXO32 (F-box protein 32). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 58039275 | 58078288 | Mouse | 276 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9049036 | Fbxo32 | F-box protein 32 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle atrophy (ortholog); negative regulation of cardiac muscle hypertrophy (ortholog); ASSOCIATED WITH atrial fibrillation (ortholog); mu scular atrophy (ortholog); primary pulmonary hypertension (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004955540 | 2309315 | 2334735 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11842180 | FBXO32 | F-box protein 32 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (inferred); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle atrophy (ortholog); negative regulation of cardiac muscle hypertrophy (ortholog); ASSOCIATED WITH atrial fibrillation (ortholog); mu scular atrophy (ortholog); primary pulmonary hypertension (ortholog); FOUND IN cytoplasm (ortholog) | 8 | 120192822 | 120236116 | Bonobo | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12066902 | FBXO32 | F-box protein 32 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (inferred); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle atrophy (ortholog); negative regulation of cardiac muscle hypertrophy (ortholog); ASSOCIATED WITH atrial fibrillation (ortholog); mu scular atrophy (ortholog); primary pulmonary hypertension (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 13 | 21804442 | 21838157 | Dog | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12722854 | Fbxo32 | F-box protein 32 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (inferred); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle atrophy (ortholog); negative regulation of cardiac muscle hypertrophy (ortholog); ASSOCIATED WITH atrial fibrillation (ortholog); mu scular atrophy (ortholog); primary pulmonary hypertension (ortholog); FOUND IN cytoplasm (ortholog) | NW_004936470 | 23886836 | 23919063 | Squirrel | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18901417 | Fbxo32 | F-box protein 32 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle atrophy (ortholog); negative regulation of cardiac muscle hypertrophy (ortholog); ASSOCIATED WITH atrial fibrillation (ortholog); mu scular atrophy (ortholog); primary pulmonary hypertension (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626140152 | Fbxo32 | F-box protein 32 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle atrophy (ortholog); negative regulation of cardiac muscle hypertrophy (ortholog); ASSOCIATED WITH atrial fibrillation (ortholog); mu scular atrophy (ortholog); primary pulmonary hypertension (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155246060 | fbxo32 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 20866679 | FBXO32 | F-box protein 32 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (inferred); INVOLVED IN negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process (inferred); protein ubiquitination (inferred); response to denervation involved in regulation of muscle adap tation (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 17 | symbol | gene, protein-coding |
| 13936424 | FBXO32 | F-box protein 32 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (inferred); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle atrophy (ortholog); negative regulation of cardiac muscle hypertrophy (ortholog); ASSOCIATED WITH atrial fibrillation (ortholog); mu scular atrophy (ortholog); primary pulmonary hypertension (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide; deoxynivalenol | | | | Pig | 34 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18474990 | FBXO32 | F-box protein 32 | ENCODES a protein that exhibits ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); muscle atrophy (ortholog); negative regulation of cardiac muscle hypertrophy (ortholog); ASSOCIATED WITH atrial fibrillation (ortholog); mu scular atrophy (ortholog); primary pulmonary hypertension (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Green Monkey | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405861441 | fbxo32.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861857 | fbxo32.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856054 | fbxo32.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 628374705 | fbxo32.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857604 | fbxo32.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155246059 | fbxo32.S | | | | | | African Clawed Frog | | symbol | gene, null |
