| 621678 | Fads1 | fatty acid desaturase 1 | ENCODES a protein that exhibits acyl-CoA (8-3)-desaturase activity; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; acyl-CoA 6-desaturase activity (ortholog); INVOLVED IN arachidonate metab olic process; response to fenofibrate; response to hormone; PARTICIPATES IN alpha-linolenic acid metabolic pathway; linoleic acid metabolic pathway; unsaturated fatty acid biosynthetic pathway; ASSOCIATED WITH Cardiac Fibrosis; congestive heart failure; Experimental Diabetes Mellitus; FOUND IN endoplasmic reticulum membrane (ortholog); mitochondrion (ortholog); INTERACTS WITH (+)-schisandrin B; (+)-sesamin; 1-(3-(trifluoromethyl)phenyl)piperazine | 1 | 216252605 | 216267618 | Rat | 292 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 731322 | Fads1 | fatty acid desaturase 1 | Enables acyl-CoA (8-3)-desaturase activity and omega-6 fatty acid desaturase activity. Involved in fatty acid derivative biosynthetic process and fatty acid metabolic process. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; eye; genitouri nary system; nervous system; and respiratory system. Orthologous to human FADS1 (fatty acid desaturase 1). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 10160245 | 10174238 | Mouse | 317 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1344024 | FADS1 | fatty acid desaturase 1 | The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008] | 11 | 61799627 | 61817003 | Human | 296 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 10300641 | Fads1 | fatty acid desaturase 1 | ENCODES a protein that exhibits acyl-CoA (8-3)-desaturase activity (ortholog); acyl-CoA 6-desaturase activity (ortholog); omega-6 fatty acid desaturase activity (ortholog); INVOLVED IN arachidonate metabolic process (ortholog); cellular response to starvation (ortholog); fatty acid biosynthetic proc ess (ortholog); PARTICIPATES IN alpha-linolenic acid metabolic pathway; linoleic acid metabolic pathway; ASSOCIATED WITH Cardiac Fibrosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | NW_004955511 | 5908394 | 5915764 | Chinchilla | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11948236 | FADS1 | fatty acid desaturase 1 | ENCODES a protein that exhibits acyl-CoA 6-desaturase activity (ortholog); oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (ortholog); INVOLVED IN arachidonate metabolic process (ortholog); cellular response to starvation (ortholog); long-chain fatty acid biosynthetic process (ortholog); PARTICIPATES IN alpha-linolenic acid metabolic pathway; linoleic acid metabolic pathway; ASSOCIATED WITH Cardiac Fibrosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); membrane (inferred); mitochondrion (inferred) | 11 | 57101553 | 57116243 | Bonobo | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12200424 | FADS1 | fatty acid desaturase 1 | ENCODES a protein that exhibits acyl-CoA 6-desaturase activity (ortholog); oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (ortholog); INVOLVED IN arachidonate metabolic process (ortholog); cellular response to starvation (ortholog); long-chain fatty acid biosynthetic process (ortholog); PARTICIPATES IN alpha-linolenic acid metabolic pathway; linoleic acid metabolic pathway; ASSOCIATED WITH Cardiac Fibrosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); FOUND IN endoplasmic reticulum membrane (inferred) | 18 | 54659406 | 54672803 | Dog | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12474497 | Fads1 | fatty acid desaturase 1 | ENCODES a protein that exhibits acyl-CoA 6-desaturase activity (ortholog); oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (ortholog); INVOLVED IN arachidonate metabolic process (ortholog); cellular response to starvation (ortholog); long-chain fatty acid biosynthetic process (ortholog); PARTICIPATES IN alpha-linolenic acid metabolic pathway; linoleic acid metabolic pathway; ASSOCIATED WITH Cardiac Fibrosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); membrane (inferred); mitochondrion (inferred) | NW_004936581 | 1312199 | 1327046 | Squirrel | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626040083 | Fads1 | fatty acid desaturase 1 | ENCODES a protein that exhibits acyl-CoA (8-3)-desaturase activity (ortholog); acyl-CoA 6-desaturase activity (ortholog); omega-6 fatty acid desaturase activity (ortholog); INVOLVED IN arachidonate metabolic process (ortholog); cellular response to starvation (ortholog); fatty acid biosynthetic proc ess (ortholog); PARTICIPATES IN alpha-linolenic acid metabolic pathway; linoleic acid metabolic pathway; ASSOCIATED WITH Cardiac Fibrosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | | | | Black Rat | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 286632185 | fads1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18410070 | FADS1 | fatty acid desaturase 1 | ENCODES a protein that exhibits acyl-CoA 6-desaturase activity (ortholog); oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (ortholog); INVOLVED IN arachidonate metabolic process (ortholog); cellular response to starvation (ortholog); long-chain fatty acid biosynthetic process (ortholog); PARTICIPATES IN alpha-linolenic acid metabolic pathway; linoleic acid metabolic pathway; ASSOCIATED WITH Cardiac Fibrosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); membrane (inferred); mitochondrion (inferred) | | | | Green Monkey | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18918734 | Fads1 | fatty acid desaturase 1 | ENCODES a protein that exhibits acyl-CoA (8-3)-desaturase activity (ortholog); acyl-CoA 6-desaturase activity (ortholog); omega-6 fatty acid desaturase activity (ortholog); INVOLVED IN arachidonate metabolic process (ortholog); cellular response to starvation (ortholog); long-chain fatty acid biosyn thetic process (ortholog); PARTICIPATES IN alpha-linolenic acid metabolic pathway; linoleic acid metabolic pathway; ASSOCIATED WITH Cardiac Fibrosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | | | | Naked Mole-Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14068670 | FADS1 | fatty acid desaturase 1 | ENCODES a protein that exhibits acyl-CoA 6-desaturase activity (ortholog); oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (ortholog); INVOLVED IN arachidonate metabolic process (ortholog); cellular response to starvation (ortholog); long-chain fatty acid biosynthetic process (ortholog); PARTICIPATES IN alpha-linolenic acid metabolic pathway; linoleic acid metabolic pathway; ASSOCIATED WITH Cardiac Fibrosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Colorectal Neoplasms (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); mitochondrion (inferred) | | | | Pig | 42 | symbol , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 285519541 | fads1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 286631725 | fads1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 9063657 | Fads3 | fatty acid desaturase 3 | INVOLVED IN gene expression (ortholog); unsaturated fatty acid biosynthetic process (ortholog) | NW_004955511 | 5814842 | 5826288 | Chinchilla | 2 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 731781 | MUSK | muscle associated receptor tyrosine kinase | This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009] | 9 | 110668791 | 110806558 | Human | 1040 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1352711 | FADS3 | fatty acid desaturase 3 | The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008] | 11 | 61873526 | 61892224 | Human | 149 | description | gene, protein-coding, REVIEWED [RefSeq] |