| 1312683 | EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development prote in, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011] | 7 | 148807383 | 148884291 | Human | 685 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1312684 | Ezh2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | Enables several functions, including DNA binding activity; RNA binding activity; and transcription corepressor activity. Involved in B cell differentiation; facultative heterochromatin formation; and regulation of circadian rhythm. Acts upstream of or within several processes, including cardiac musc le hypertrophy in response to stress; negative regulation of cell differentiation; and regulation of DNA-templated transcription. Located in pericentric heterochromatin and pronucleus. Part of ESC/E(Z) complex and chromatin silencing complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Used to study B-cell lymphoma; Weaver syndrome; and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Weaver syndrome; gastrointestinal system cancer (multiple); glioblastoma; hematologic cancer (multiple); and renal Wilms' tumor. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 47507208 | 47613843 | Mouse | 599 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1595860 | Ezh2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | ENCODES a protein that exhibits chromatin binding; transcription cis-regulatory region binding; chromatin DNA binding (ortholog); INVOLVED IN hippocampus development; negative regulation of cytokine production involved in inflammatory response; negative regulation of gene expression; PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; ASSOCIATED WITH endometriosis; Experimental Diabetes Mellitus; Left Ventricular Hypertrophy; FOUND IN chromatin (ortholog); chromatin silencing complex (ortholog); chromosome (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 4 | 77624223 | 77698598 | Rat | 516 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 9010311 | Ezh2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN B cell differentiation (ortholog); cardiac muscle hypertrophy in response to stress (ortholog); cell development (ortholog); PARTICIPATES IN histone modification pathwa y; methionine cycle/metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute lymphoblastic leukemia (ortholog); acute megakaryocytic leukemia (ortholog); FOUND IN chromatin (ortholog); chromatin silencing complex (ortholog); chromosome (ortholog) | NW_004955491 | 4215353 | 4292229 | Chinchilla | 230 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11910231 | EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | ENCODES a protein that exhibits chromatin binding (ortholog); transcription cis-regulatory region binding (ortholog); INVOLVED IN cardiac muscle hypertrophy in response to stress (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to trichostatin A (ortholog); PARTICIPAT ES IN histone modification pathway; methionine cycle/metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute lymphoblastic leukemia (ortholog); acute megakaryocytic leukemia (ortholog); FOUND IN nucleus (ortholog); PcG protein complex (ortholog) | 7 | 140536962 | 140613104 | Bonobo | 234 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12069277 | EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN B cell differentiation (ortholog); cardiac muscle hypertrophy in response to stress (ortholog); cell development (ortholog); PARTICIPATES IN histone modification pathwa y; methionine cycle/metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute lymphoblastic leukemia (ortholog); acute megakaryocytic leukemia (ortholog); FOUND IN chromatin (ortholog); chromatin silencing complex (ortholog); chromosome (ortholog) | 16 | 1926443 | 1991995 | Dog | 235 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12579393 | Ezh2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | ENCODES a protein that exhibits chromatin binding (ortholog); transcription cis-regulatory region binding (ortholog); INVOLVED IN cardiac muscle hypertrophy in response to stress (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to trichostatin A (ortholog); PARTICIPAT ES IN histone modification pathway; methionine cycle/metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute lymphoblastic leukemia (ortholog); acute megakaryocytic leukemia (ortholog); FOUND IN nucleus (ortholog); PcG protein complex (ortholog) | NW_004936527 | 5024077 | 5069152 | Squirrel | 238 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13951749 | EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | ENCODES a protein that exhibits chromatin binding (ortholog); transcription cis-regulatory region binding (ortholog); INVOLVED IN cardiac muscle hypertrophy in response to stress (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to trichostatin A (ortholog); PARTICIPAT ES IN histone modification pathway; methionine cycle/metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute lymphoblastic leukemia (ortholog); acute megakaryocytic leukemia (ortholog); FOUND IN PcG protein complex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 233 | symbol , old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 18732858 | EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | ENCODES a protein that exhibits chromatin binding (ortholog); transcription cis-regulatory region binding (ortholog); INVOLVED IN cardiac muscle hypertrophy in response to stress (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to trichostatin A (ortholog); PARTICIPAT ES IN histone modification pathway; methionine cycle/metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute lymphoblastic leukemia (ortholog); acute megakaryocytic leukemia (ortholog); FOUND IN nucleus (ortholog); PcG protein complex (ortholog) | | | | Green Monkey | 233 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18907301 | Ezh2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN B cell differentiation (ortholog); cardiac muscle hypertrophy in response to stress (ortholog); cell development (ortholog); PARTICIPATES IN histone modification pathwa y; methionine cycle/metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute lymphoblastic leukemia (ortholog); acute megakaryocytic leukemia (ortholog); FOUND IN chromatin (ortholog); chromatin silencing complex (ortholog); chromosome (ortholog) | | | | Naked Mole-Rat | 237 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155235835 | ezh2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626162167 | Ezh2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN B cell differentiation (ortholog); cardiac muscle hypertrophy in response to stress (ortholog); cell development (ortholog); PARTICIPATES IN histone modification pathwa y; methionine cycle/metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute lymphoblastic leukemia (ortholog); acute megakaryocytic leukemia (ortholog); FOUND IN chromatin (ortholog); chromatin silencing complex (ortholog); chromosome (ortholog) | | | | Black Rat | 230 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155244549 | ezh2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155255711 | ezh2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 18901029 | LOC101726594 | histone-lysine N-methyltransferase EZH2-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 625980804 | LOC116884938 | histone-lysine N-methyltransferase EZH2-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 402186406 | LOC134483084 | histone-lysine N-methyltransferase EZH2-like | | 18 | 12455021 | 12475083 | Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 14974728 | PCSEAT | prostate cancer expressed EZH2 associated transcript | | 21 | 41580475 | 41582887 | Human | | name | gene, ncrna, VALIDATED [RefSeq] |
| 7207545 | HEIH | hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA | Biomarker of esophagus squamous cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 180829954 | 180831618 | Human | 10 | name | gene, ncrna, VALIDATED [RefSeq] |
| 5131322 | EZH2P1 | enhancer of zeste 2 polycomb repressive complex 2 subunit pseudogene 1 | | 21 | 35599665 | 35600039 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo |
| 1619223 | Suz12 | SUZ12 polycomb repressive complex 2 subunit | This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2 style='font-weight:700;'>EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009] | 11 | 79883932 | 79924949 | Mouse | 233 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1312814 | Ezh1 | enhancer of zeste 1 polycomb repressive complex 2 subunit | This gene encodes a member of the Polycomb-group (PcG) family. The encoded protein is interchangeable with the related Enhancer of zeste 2 (Ezh2) protein as a core component of the polycomb repressive complex 2 (PRC2), which methylates histone H3 at lysine 27 an d results in the transcriptional repression of affected target genes. This complex is involved in carrying out cell-fate decisions during embryonic stem cell differentiation. [provided by RefSeq, Sep 2014] | 11 | 101081941 | 101117268 | Mouse | 173 | description | gene, protein-coding, REVIEWED [RefSeq] |