| 619961 | Exoc2 | exocyst complex component 2 | ENCODES a protein that exhibits protein kinase binding (ortholog); small GTPase binding (ortholog); INVOLVED IN Golgi to plasma membrane transport (ortholog); regulation of entry of bacterium into host cell (ortholog); vesicle docking involved in exocytosis (ortholog); PARTICIPATES IN insulin signal ing pathway; ASSOCIATED WITH NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND CEREBELLAR HYPOPLASIA (ortholog); prostate cancer (ortholog); FOUND IN exocyst; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 17 | 33714949 | 33906901 | Rat | 116 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1348584 | EXOC2 | exocyst complex component 2 | The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst com plex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] | 6 | 485154 | 693139 | Human | 162 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1551015 | Exoc2 | exocyst complex component 2 | Enables small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane transport; regulation of entry of bacterium into host cell; and vesicle docking involved in exocytosis. Predicted to act upstream of or within positive regulation of exocytosis. Predicted to be located in pla sma membrane. Predicted to be part of exocyst. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and palatal shelf. Orthologous to human EXOC2 (exocyst complex component 2). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 30968421 | 31162082 | Mouse | 122 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8851192 | Exoc2 | exocyst complex component 2 | ENCODES a protein that exhibits protein kinase binding (ortholog); small GTPase binding (ortholog); INVOLVED IN Golgi to plasma membrane transport (ortholog); regulation of entry of bacterium into host cell (ortholog); vesicle docking involved in exocytosis (ortholog); PARTICIPATES IN insulin signal ing pathway; ASSOCIATED WITH NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND CEREBELLAR HYPOPLASIA (ortholog); prostate cancer (ortholog); FOUND IN exocyst (ortholog) | NW_004955465 | 12327423 | 12457171 | Chinchilla | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11718365 | EXOC2 | exocyst complex component 2 | ENCODES a protein that exhibits GTP-dependent protein binding (inferred); protein kinase binding (inferred); small GTPase binding (inferred); INVOLVED IN exocytosis (inferred); Golgi to plasma membrane transport (inferred); protein transport (inferred); PARTICIPATES IN insulin signaling pathway; ASS OCIATED WITH NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND CEREBELLAR HYPOPLASIA (ortholog); prostate cancer (ortholog); FOUND IN exocyst (ortholog) | 6 | 299500 | 504029 | Bonobo | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12058623 | EXOC2 | exocyst complex component 2 | ENCODES a protein that exhibits GTP-dependent protein binding (inferred); protein kinase binding (inferred); small GTPase binding (inferred); INVOLVED IN exocytosis (inferred); Golgi to plasma membrane transport (inferred); protein transport (inferred); PARTICIPATES IN insulin signaling pathway; ASS OCIATED WITH NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND CEREBELLAR HYPOPLASIA (ortholog); prostate cancer (ortholog); FOUND IN exocyst (ortholog) | 35 | 859158 | 1084228 | Dog | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12691008 | Exoc2 | exocyst complex component 2 | ENCODES a protein that exhibits GTP-dependent protein binding (inferred); protein kinase binding (inferred); small GTPase binding (inferred); INVOLVED IN exocytosis (inferred); Golgi to plasma membrane transport (inferred); protein transport (inferred); PARTICIPATES IN insulin signaling pathway; ASS OCIATED WITH NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND CEREBELLAR HYPOPLASIA (ortholog); prostate cancer (ortholog); FOUND IN exocyst (ortholog) | NW_004936633 | 1657326 | 1848113 | Squirrel | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13978032 | EXOC2 | exocyst complex component 2 | ENCODES a protein that exhibits GTP-dependent protein binding (inferred); protein kinase binding (inferred); small GTPase binding (inferred); INVOLVED IN exocytosis (inferred); Golgi to plasma membrane transport (inferred); protein transport (inferred); PARTICIPATES IN insulin signaling pathway; ASS OCIATED WITH NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND CEREBELLAR HYPOPLASIA (ortholog); prostate cancer (ortholog); FOUND IN exocyst (ortholog) | | | | Pig | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18932744 | Exoc2 | exocyst complex component 2 | ENCODES a protein that exhibits GTP-dependent protein binding (inferred); protein kinase binding (inferred); small GTPase binding (inferred); INVOLVED IN exocytosis (inferred); Golgi to plasma membrane transport (inferred); protein transport (inferred); PARTICIPATES IN insulin signaling pathway; ASS OCIATED WITH NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND CEREBELLAR HYPOPLASIA (ortholog); prostate cancer (ortholog); FOUND IN exocyst (ortholog) | | | | Naked Mole-Rat | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247450 | exoc2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18608162 | EXOC2 | exocyst complex component 2 | ENCODES a protein that exhibits GTP-dependent protein binding (inferred); protein kinase binding (inferred); small GTPase binding (inferred); INVOLVED IN exocytosis (inferred); Golgi to plasma membrane transport (inferred); protein transport (inferred); PARTICIPATES IN insulin signaling pathway; ASS OCIATED WITH NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND CEREBELLAR HYPOPLASIA (ortholog); prostate cancer (ortholog); FOUND IN exocyst (ortholog) | | | | Green Monkey | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626124075 | Exoc2 | exocyst complex component 2 | ENCODES a protein that exhibits protein kinase binding (ortholog); small GTPase binding (ortholog); INVOLVED IN Golgi to plasma membrane transport (ortholog); regulation of entry of bacterium into host cell (ortholog); vesicle docking involved in exocytosis (ortholog); PARTICIPATES IN insulin signal ing pathway; ASSOCIATED WITH NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND CEREBELLAR HYPOPLASIA (ortholog); prostate cancer (ortholog); FOUND IN exocyst (ortholog) | | | | Black Rat | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247449 | exoc2.L | | | | | | African Clawed Frog | | symbol | gene, null |
