| 619772 | Epn1 | Epsin 1 | ENCODES a protein that exhibits clathrin adaptor activity; transcription factor binding; transmembrane transporter binding; INVOLVED IN clathrin coat assembly; endocytosis; membrane fission; PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; endocytosis pathway; ASSOCIATED WITH middle cerebral artery infarction; FOUND IN cytosol; plasma membrane; postsynapse; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 1 | 77771335 | 77789411 | Rat | 114 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1332250 | Epn1 | epsin 1 | Predicted to enable several functions, including clathrin adaptor activity; clathrin binding activity; and transmembrane transporter binding activity. Acts upstream of or within several processes, including Notch signaling pathway; female pregnancy; and in utero embryonic development. Predicted to b e located in cytosol; postsynaptic membrane; and presynaptic membrane. Predicted to be part of clathrin vesicle coat. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; endosome; and postsynapse. Is expressed in embryo. Orthologous to human EPN1 (epsin 1). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 5083207 | 5101178 | Mouse | 145 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1342807 | EPN1 | epsin 1 | This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016] | 19 | 55675226 | 55709533 | Human | 104 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8771879 | Epn1 | epsin 1 | ENCODES a protein that exhibits clathrin adaptor activity (ortholog); molecular sequestering activity (ortholog); transcription factor binding (ortholog); INVOLVED IN clathrin coat assembly (ortholog); embryonic organ development (ortholog); endocytosis (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ASSOCIATED WITH middle cerebral artery infarction (ortholog); FOUND IN cytosol (ortholog); plasma membrane (ortholog); postsynapse (ortholog) | NW_004955567 | 669333 | 683283 | Chinchilla | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11762513 | EPN1 | epsin 1 | ENCODES a protein that exhibits clathrin adaptor activity (ortholog); transcription factor binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN clathrin coat assembly (ortholog); embryonic organ development (ortholog); endocytosis (ortholog); PARTICIPATES IN clathrin-depende nt synaptic vesicle endocytosis; ASSOCIATED WITH middle cerebral artery infarction (ortholog); FOUND IN cytosol (ortholog); postsynapse (ortholog); postsynaptic membrane (ortholog) | 19 | 52722107 | 52743321 | Bonobo | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12385171 | EPN1 | epsin 1 | ENCODES a protein that exhibits clathrin adaptor activity (ortholog); molecular sequestering activity (ortholog); transcription factor binding (ortholog); INVOLVED IN clathrin coat assembly (ortholog); embryonic organ development (ortholog); endocytosis (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ASSOCIATED WITH middle cerebral artery infarction (ortholog); FOUND IN cytosol (ortholog); plasma membrane (ortholog); postsynapse (ortholog) | 1 | 102059022 | 102073665 | Dog | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12704211 | Epn1 | epsin 1 | ENCODES a protein that exhibits clathrin adaptor activity (ortholog); transcription factor binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN clathrin coat assembly (ortholog); embryonic organ development (ortholog); endocytosis (ortholog); PARTICIPATES IN clathrin-depende nt synaptic vesicle endocytosis; ASSOCIATED WITH middle cerebral artery infarction (ortholog); FOUND IN cytosol (ortholog); postsynapse (ortholog); postsynaptic membrane (ortholog) | NW_004936981 | 194176 | 213021 | Squirrel | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18903040 | Epn1 | epsin 1 | ENCODES a protein that exhibits clathrin adaptor activity (ortholog); molecular sequestering activity (ortholog); transcription factor binding (ortholog); INVOLVED IN clathrin coat assembly (ortholog); embryonic organ development (ortholog); endocytosis (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ASSOCIATED WITH middle cerebral artery infarction (ortholog); FOUND IN cytosol (ortholog); postsynapse (ortholog); postsynaptic membrane (ortholog) | | | | Naked Mole-Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626033765 | Epn1 | epsin 1 | ENCODES a protein that exhibits clathrin adaptor activity (ortholog); molecular sequestering activity (ortholog); transcription factor binding (ortholog); INVOLVED IN clathrin coat assembly (ortholog); embryonic organ development (ortholog); endocytosis (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ASSOCIATED WITH middle cerebral artery infarction (ortholog); FOUND IN cytosol (ortholog); plasma membrane (ortholog); postsynapse (ortholog) | | | | Black Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14052997 | EPN1 | epsin 1 | ENCODES a protein that exhibits clathrin adaptor activity (ortholog); transcription factor binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN clathrin coat assembly (ortholog); embryonic organ development (ortholog); endocytosis (ortholog); PARTICIPATES IN clathrin-depende nt synaptic vesicle endocytosis; ASSOCIATED WITH middle cerebral artery infarction (ortholog); FOUND IN cytosol (ortholog); plasma membrane (ortholog); postsynapse (ortholog) | | | | Pig | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18339092 | EPN1 | epsin 1 | ENCODES a protein that exhibits clathrin adaptor activity (ortholog); transcription factor binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN clathrin coat assembly (ortholog); embryonic organ development (ortholog); endocytosis (ortholog); PARTICIPATES IN clathrin-depende nt synaptic vesicle endocytosis; ASSOCIATED WITH middle cerebral artery infarction (ortholog); FOUND IN cytosol (ortholog); postsynapse (ortholog); postsynaptic membrane (ortholog) | | | | Green Monkey | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250490 | epn1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155250491 | epn1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155254767 | epn1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16564455 | AC010525.1 | novel transcript, antisense to EPN1 | | | | | Human | | name | gene, lncrna |
| 737072 | ITSN1 | intersectin 1 | The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle re cycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008] | 21 | 33642501 | 33899861 | Human | 255 | description | gene, protein-coding, REVIEWED [RefSeq] |