| 1311645 | Enpp6 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | ENCODES a protein that exhibits glycerophosphocholine cholinephosphodiesterase activity (ortholog); glycerophosphodiester phosphodiesterase activity (ortholog); phosphoric diester hydrolase activity (ortholog); INVOLVED IN choline metabolic process (ortholog); lipid metabolic process (ortholog); PAR TICIPATES IN ether lipid metabolic pathway; ether lipid metabolic pathway; ASSOCIATED WITH autistic disorder (ortholog); FOUND IN extracellular region (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; acrylamide | 16 | 51898557 | 52026789 | Rat | 98 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1323210 | ENPP6 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | Enables glycerophosphocholine cholinephosphodiesterase activity. Involved in choline metabolic process and lipid metabolic process. Located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 184088706 | 184217873 | Human | 84 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1323211 | Enpp6 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | This gene encodes a member of the nucleotide pyrophosphatase/phosphodiesterase family of enzymes that play an important role in regulating extracellular nucleotide metabolism. The encoded preproprotein undergoes proteolytic processing to generate a glycosylphosphatidylinositol (GPI)-anchored membran e protein that hydrolyzes choline-containing lysophospholipids such as glycerophosphocholine. Mice lacking the encoded protein develop fatty liver and myelin sheath abnormalities. [provided by RefSeq, Jul 2016] | 8 | 47439920 | 47549797 | Mouse | 98 | symbol , old_gene_name , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8807361 | Enpp6 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | ENCODES a protein that exhibits glycerophosphocholine cholinephosphodiesterase activity (ortholog); glycerophosphodiester phosphodiesterase activity (ortholog); phosphoric diester hydrolase activity (ortholog); INVOLVED IN choline metabolic process (ortholog); lipid metabolic process (ortholog); ASS OCIATED WITH autistic disorder (ortholog); FOUND IN extracellular region (ortholog); plasma membrane (ortholog) | NW_004955403 | 24528644 | 24788878 | Chinchilla | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11900879 | ENPP6 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | ENCODES a protein that exhibits glycerophosphocholine cholinephosphodiesterase activity (inferred); glycerophosphodiester phosphodiesterase activity (inferred); hydrolase activity (inferred); INVOLVED IN choline metabolic process (ortholog); ASSOCIATED WITH autistic disorder (ortholog); FOUND IN ext racellular region (inferred); plasma membrane (inferred); side of membrane (inferred) | 4 | 176259291 | 176388497 | Bonobo | 24 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12130018 | ENPP6 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | ENCODES a protein that exhibits glycerophosphocholine cholinephosphodiesterase activity (inferred); glycerophosphodiester phosphodiesterase activity (inferred); hydrolase activity (inferred); INVOLVED IN choline metabolic process (ortholog); ASSOCIATED WITH autistic disorder (ortholog); FOUND IN ext racellular region (inferred); plasma membrane (inferred); side of membrane (inferred) | 16 | 46247121 | 46359683 | Dog | 24 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12720965 | Enpp6 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | ENCODES a protein that exhibits glycerophosphocholine cholinephosphodiesterase activity (inferred); glycerophosphodiester phosphodiesterase activity (inferred); hydrolase activity (inferred); INVOLVED IN choline metabolic process (ortholog); ASSOCIATED WITH autistic disorder (ortholog); FOUND IN ext racellular region (inferred); plasma membrane (inferred); side of membrane (inferred) | NW_004936554 | 4972982 | 5077092 | Squirrel | 24 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18645550 | ENPP6 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | ENCODES a protein that exhibits glycerophosphocholine cholinephosphodiesterase activity (inferred); glycerophosphodiester phosphodiesterase activity (inferred); hydrolase activity (inferred); INVOLVED IN choline metabolic process (ortholog); ASSOCIATED WITH autistic disorder (ortholog); FOUND IN ext racellular region (inferred); plasma membrane (inferred); side of membrane (inferred) | | | | Green Monkey | 24 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18901962 | Enpp6 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | ENCODES a protein that exhibits glycerophosphocholine cholinephosphodiesterase activity (inferred); glycerophosphodiester phosphodiesterase activity (inferred); hydrolase activity (inferred); INVOLVED IN choline metabolic process (ortholog); ASSOCIATED WITH autistic disorder (ortholog); FOUND IN ext racellular region (inferred); plasma membrane (inferred); side of membrane (inferred) | | | | Naked Mole-Rat | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249890 | enpp6 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13846113 | ENPP6 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | ENCODES a protein that exhibits glycerophosphocholine cholinephosphodiesterase activity (ortholog); phosphoric diester hydrolase activity (ortholog); INVOLVED IN choline metabolic process (ortholog); lipid metabolic process (ortholog); ASSOCIATED WITH autistic disorder (ortholog); FOUND IN plasma me mbrane (ortholog); INTERACTS WITH deoxynivalenol; graphene oxide | | | | Pig | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625911473 | Enpp6 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | ENCODES a protein that exhibits glycerophosphocholine cholinephosphodiesterase activity (ortholog); glycerophosphodiester phosphodiesterase activity (ortholog); phosphoric diester hydrolase activity (ortholog); INVOLVED IN choline metabolic process (ortholog); lipid metabolic process (ortholog); ASS OCIATED WITH autistic disorder (ortholog); FOUND IN extracellular region (ortholog); plasma membrane (ortholog) | | | | Black Rat | 13 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155237496 | enpp6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 16572520 | AC107222.2 | novel transcript, antisense to ENPP6 | | | | | Human | | name | gene, lncrna |