ENPP6 (ectonucleotide pyrophosphatase/phosphodiesterase 6) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: ENPP6 (ectonucleotide pyrophosphatase/phosphodiesterase 6) Sus scrofa
Analyze
Symbol: ENPP6
Name: ectonucleotide pyrophosphatase/phosphodiesterase 6
RGD ID: 13846113
Description: ENCODES a protein that exhibits glycerophosphocholine cholinephosphodiesterase activity (ortholog); phosphoric diester hydrolase activity (ortholog); INVOLVED IN choline metabolic process (ortholog); lipid metabolic process (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Choline-specific glycerophosphodiester phosphodiesterase; E-NPP 6; Ectonucleotide pyrophosphatase/phosphodiesterase family member 6; Glycerophosphocholine cholinephosphodiesterase; GPC-Cpde; NPP-6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1545,357,816 - 45,441,134 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11545,357,805 - 45,441,133 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21551,972,092 - 52,015,300 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:15679890   PMID:17145712  


Genomics

Comparative Map Data
ENPP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1545,357,816 - 45,441,134 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11545,357,805 - 45,441,133 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21551,972,092 - 52,015,300 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ENPP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384184,088,706 - 184,217,873 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4184,088,706 - 184,221,230 (-)EnsemblGRCh38hg38GRCh38
GRCh374185,009,859 - 185,139,026 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364185,246,853 - 185,376,013 (-)NCBINCBI36Build 36hg18NCBI36
Build 344185,385,008 - 185,514,168NCBI
Celera4182,338,726 - 182,467,954 (-)NCBICelera
Cytogenetic Map4q35.1NCBI
HuRef4180,764,953 - 180,894,206 (-)NCBIHuRef
CHM1_14184,986,462 - 185,115,656 (-)NCBICHM1_1
T2T-CHM13v2.04187,432,563 - 187,561,688 (-)NCBIT2T-CHM13v2.0
Enpp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39847,439,920 - 47,549,797 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl847,439,922 - 47,549,797 (+)EnsemblGRCm39 Ensembl
GRCm38846,939,197 - 47,096,762 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl846,986,887 - 47,096,762 (+)EnsemblGRCm38mm10GRCm38
MGSCv37848,072,279 - 48,180,249 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36848,485,742 - 48,593,712 (+)NCBIMGSCv36mm8
Celera849,669,997 - 49,780,091 (+)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map826.48NCBI
Enpp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81651,898,557 - 52,026,789 (-)NCBIGRCr8
mRatBN7.21645,165,883 - 45,294,126 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1645,169,178 - 45,294,077 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1650,579,560 - 50,693,583 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01653,939,449 - 54,060,290 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01649,218,956 - 49,332,983 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01648,315,500 - 48,437,258 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1648,315,914 - 48,437,242 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01648,028,039 - 48,150,740 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41648,396,463 - 48,516,698 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11648,392,661 - 48,516,789 (-)NCBI
Celera1643,179,659 - 43,298,753 (-)NCBICelera
Cytogenetic Map16q11NCBI
Enpp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540324,674,012 - 24,788,947 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540324,528,644 - 24,788,878 (+)NCBIChiLan1.0ChiLan1.0
ENPP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23181,813,324 - 181,945,361 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14182,176,798 - 182,308,794 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04176,259,291 - 176,388,497 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14188,483,901 - 188,613,382 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4188,483,901 - 188,613,382 (-)Ensemblpanpan1.1panPan2
ENPP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11646,247,121 - 46,359,683 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1646,247,541 - 46,356,579 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1646,740,776 - 46,852,776 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01648,464,581 - 48,576,564 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1648,464,610 - 48,573,422 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11646,428,949 - 46,540,950 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01647,043,141 - 47,155,346 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01647,177,087 - 47,289,467 (+)NCBIUU_Cfam_GSD_1.0
Enpp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494333,029,668 - 33,137,003 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365544,972,982 - 5,077,092 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365544,972,982 - 5,077,092 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENPP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17130,058,085 - 130,183,642 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7130,060,651 - 130,182,624 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037110,312,090 - 110,437,816 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enpp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476914,858,893 - 14,989,246 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476914,859,023 - 14,989,240 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ENPP6
2278 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 2 2 9 2
Low 7 2 3 3 14 3 1
Below cutoff 2 1

Sequence


RefSeq Acc Id: ENSSSCT00000017182   ⟹   ENSSSCP00000016721
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1545,357,816 - 45,441,134 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000085824   ⟹   ENSSSCP00000072424
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1545,357,861 - 45,478,296 (-)Ensembl
RefSeq Acc Id: XM_021074886   ⟹   XP_020930545
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11545,357,805 - 45,441,133 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020930545   ⟸   XM_021074886
- UniProtKB: Q58D68 (UniProtKB/Swiss-Prot),   A0A4X1VWA0 (UniProtKB/TrEMBL),   F1RSZ8 (UniProtKB/TrEMBL),   A0A8D0YBS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000072424   ⟸   ENSSSCT00000085824
RefSeq Acc Id: ENSSSCP00000016721   ⟸   ENSSSCT00000017182


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000015781 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00005029866 UniProtKB/TrEMBL
  ENSSSCG00015047002 UniProtKB/TrEMBL
  ENSSSCG00025030018 UniProtKB/TrEMBL
  ENSSSCG00030050057 UniProtKB/TrEMBL
  ENSSSCG00035002599 UniProtKB/TrEMBL
  ENSSSCG00045002058 UniProtKB/TrEMBL
  ENSSSCG00050025052 UniProtKB/TrEMBL
  ENSSSCG00055001102 UniProtKB/TrEMBL
  ENSSSCG00060051589 UniProtKB/TrEMBL
  ENSSSCG00065001422 UniProtKB/TrEMBL
  ENSSSCG00070027227 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000017182 ENTREZGENE
  ENSSSCT00000017182.4 UniProtKB/TrEMBL
  ENSSSCT00000017182.5 UniProtKB/Swiss-Prot
  ENSSSCT00005047474.1 UniProtKB/TrEMBL
  ENSSSCT00015062714.1 UniProtKB/TrEMBL
  ENSSSCT00025040803.1 UniProtKB/TrEMBL
  ENSSSCT00030069763.1 UniProtKB/TrEMBL
  ENSSSCT00035003242.1 UniProtKB/TrEMBL
  ENSSSCT00045003199.1 UniProtKB/TrEMBL
  ENSSSCT00050033706.1 UniProtKB/TrEMBL
  ENSSSCT00055001966.1 UniProtKB/TrEMBL
  ENSSSCT00060070218.1 UniProtKB/TrEMBL
  ENSSSCT00065001757.1 UniProtKB/TrEMBL
  ENSSSCT00070054608.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1360.180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.720.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Alkaline_phosphatase_core_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphodiest/P_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene ENPP6 ENTREZGENE
PANTHER ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10151:SF66 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Phosphodiest UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53649 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1VWA0 ENTREZGENE
  A0A8D0YBS3 ENTREZGENE, UniProtKB/TrEMBL
  ENPP6_PIG UniProtKB/Swiss-Prot
  F1RSZ8 ENTREZGENE, UniProtKB/TrEMBL
  Q58D68 ENTREZGENE
UniProt Secondary A0A4X1VWA0 UniProtKB/TrEMBL
VGNC ID VGNC:95999 ENTREZGENE