| 735192 | Eif2s2 | eukaryotic translation initiation factor 2 subunit beta | ENCODES a protein that exhibits translation initiation factor activity (ortholog); INVOLVED IN cytoplasmic translational initiation (ortholog); in utero embryonic development (ortholog); male germ cell proliferation (ortholog); PARTICIPATES IN translation initiation pathway; RNA transport pathway; A SSOCIATED WITH Breast Neoplasms (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN cytoplasm (ortholog); eukaryotic translation initiation factor 2 complex (ortholog); nucleus (ortholog); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 3 | 163834846 | 163855733 | Rat | 171 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1343864 | EIF2S2 | eukaryotic translation initiation factor 2 subunit beta | Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene rep resenting the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] | 20 | 34088309 | 34112243 | Human | 187 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1550333 | Eif2s2 | eukaryotic translation initiation factor 2 subunit 2 beta | Predicted to enable mRNA binding activity; translation initiation factor activity; and translation initiation factor binding activity. Acts upstream of or within in utero embryonic development; male germ cell proliferation; and male gonad development. Is active in synapse. Is expressed in several st ructures, including blastocyst; colon; early embryo; gonad; and liver. Orthologous to human EIF2S2 (eukaryotic translation initiation factor 2 subunit beta). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 154713330 | 154734826 | Mouse | 193 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8736996 | Eif2s2 | eukaryotic translation initiation factor 2 subunit beta | ENCODES a protein that exhibits translation initiation factor activity (ortholog); INVOLVED IN cytoplasmic translational initiation (ortholog); in utero embryonic development (ortholog); male germ cell proliferation (ortholog); PARTICIPATES IN translation initiation pathway; ASSOCIATED WITH Breast N eoplasms (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN cytoplasm (ortholog); eukaryotic translation initiation factor 2 complex (ortholog); nucleus (ortholog) | NW_004955422 | 27245381 | 27263342 | Chinchilla | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11924390 | EIF2S2 | eukaryotic translation initiation factor 2 subunit beta | ENCODES a protein that exhibits mRNA binding (inferred); translation initiation factor activity (inferred); translation initiation factor binding (inferred); INVOLVED IN cytoplasmic translational initiation (ortholog); in utero embryonic development (ortholog); male germ cell proliferation (ortholog ); PARTICIPATES IN translation initiation pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); synapse (ortholog) | 20 | 30380226 | 30403049 | Bonobo | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12338927 | EIF2S2 | eukaryotic translation initiation factor 2 subunit beta | ENCODES a protein that exhibits translation initiation factor activity (inferred); INVOLVED IN cytoplasmic translational initiation (ortholog); in utero embryonic development (ortholog); male germ cell proliferation (ortholog); PARTICIPATES IN translation initiation pathway; ASSOCIATED WITH Breast N eoplasms (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); synapse (ortholog) | 24 | 23268263 | 23289038 | Dog | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12513403 | Eif2s2 | eukaryotic translation initiation factor 2 subunit beta | ENCODES a protein that exhibits mRNA binding (inferred); translation initiation factor activity (inferred); translation initiation factor binding (inferred); INVOLVED IN in utero embryonic development (ortholog); male germ cell proliferation (ortholog); male gonad development (ortholog); PARTICIPATE S IN translation initiation pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN nucleus (ortholog) | NW_004936561 | 6529204 | 6548126 | Squirrel | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14122115 | EIF2S2 | eukaryotic translation initiation factor 2 subunit beta | ENCODES a protein that exhibits translation initiation factor activity (inferred); INVOLVED IN in utero embryonic development (ortholog); male germ cell proliferation (ortholog); male gonad development (ortholog); PARTICIPATES IN translation initiation pathway; ASSOCIATED WITH Breast Neoplasms (orth olog); Testicular Germ Cell Tumor (ortholog); FOUND IN nucleus (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18585323 | EIF2S2 | eukaryotic translation initiation factor 2 subunit beta | ENCODES a protein that exhibits translation initiation factor activity (ortholog); INVOLVED IN cytoplasmic translational initiation (ortholog); in utero embryonic development (ortholog); male germ cell proliferation (ortholog); PARTICIPATES IN translation initiation pathway; ASSOCIATED WITH Breast N eoplasms (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN cytoplasm (ortholog); eukaryotic translation initiation factor 2 complex (ortholog); nucleus (ortholog) | | | | Green Monkey | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904952 | Eif2s2 | eukaryotic translation initiation factor 2 subunit beta | ENCODES a protein that exhibits mRNA binding (inferred); translation initiation factor activity (inferred); translation initiation factor binding (inferred); INVOLVED IN cytoplasmic translational initiation (ortholog); in utero embryonic development (ortholog); male germ cell proliferation (ortholog ); PARTICIPATES IN translation initiation pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); synapse (ortholog) | | | | Naked Mole-Rat | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866830 | EIF2S2 | eukaryotic translation initiation factor 2 subunit beta | ENCODES a protein that exhibits mRNA binding (inferred); translation initiation factor activity (inferred); translation initiation factor binding (inferred); INVOLVED IN cytoplasmic translational initiation (inferred); formation of translation preinitiation complex (inferred); translational initiati on (inferred); FOUND IN cytoplasm (inferred); eukaryotic translation initiation factor 2 complex (inferred); synapse (inferred) | | | | Green Monkey | 13 | symbol | gene, protein-coding |
| 405856580 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405857030 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405857194 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405857498 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405857696 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405858567 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405858610 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405859301 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405861551 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405861939 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405862294 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405863027 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405863842 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 405864822 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626125477 | Eif2s2 | eukaryotic translation initiation factor 2 subunit beta | ENCODES a protein that exhibits translation initiation factor activity (ortholog); INVOLVED IN cytoplasmic translational initiation (ortholog); in utero embryonic development (ortholog); male germ cell proliferation (ortholog); PARTICIPATES IN translation initiation pathway; ASSOCIATED WITH Breast N eoplasms (ortholog); Testicular Germ Cell Tumor (ortholog); FOUND IN cytoplasm (ortholog); eukaryotic translation initiation factor 2 complex (ortholog); nucleus (ortholog) | | | | Black Rat | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626171383 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626172355 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626179229 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626188044 | eif2s2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 598151543 | eif2s2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 616363086 | eif2s2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 41094357 | Eif2s2-ps1 | eukaryotic translation initiation factor 2 subunit beta, pseudogene 1 | | 1 | 223183997 | 223185294 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 16565816 | AC010738.1 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa (EIF2S2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16561851 | AL161670.2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa (EIF2S2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16560243 | AP001646.1 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa (EIF2S2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 16552276 | AL021407.1 | pseudogene similar to part of eukaryotic translation initiation factor 2 subunit 2 EIF2S2 | | | | | Human | | name | gene, processed_pseudogene |
| 1349546 | EIF2S2P1 | eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 1 | | 14 | 63734675 | 63736219 | Human | | symbol , GTEx , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1343874 | EIF2S2P2 | eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 2 | INTERACTS WITH benzo[a]pyrene | 3 | 185245166 | 185246567 | Human | 1 | symbol , COSMIC , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 1352428 | EIF2S2P3 | eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 3 | | 10 | 92668451 | 92669847 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 2800935 | EIF2S2P4 | eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 4 | INTERACTS WITH aristolochic acid A; cadmium dichloride; lead diacetate | 2 | 170751691 | 170753082 | Human | 3 | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 4108858 | EIF2S2P5 | eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 5 | | 1 | 114468205 | 114469566 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 3231911 | EIF2S2P6 | eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 6 | | 11 | 82835412 | 82837442 | Human | | symbol , GTEx , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 2881249 | EIF2S2P7 | eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 7 | | 2 | 57048152 | 57049465 | Human | | symbol , GTEx , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 735608 | EIF2S1 | eukaryotic translation initiation factor 2 subunit alpha | The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36- kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010] | 14 | 67360328 | 67386516 | Human | 641 | description | gene, protein-coding, VALIDATED [RefSeq] |