| 628879 | Eaf2 | ELL associated factor 2 | ENCODES a protein that exhibits transcription elongation factor activity (ortholog); INVOLVED IN negative regulation of cell growth (ortholog); negative regulation of epithelial cell proliferation involved in prostate gland development (ortholog); positive regulation of DNA-templated transcription ( ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH B-cell lymphoma (ortholog); COVID-19 (ortholog); hepatocellular carcinoma (ortholog); FOUND IN nucleoplasm (ortholog); transcription elongation factor complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; acrylamide | 11 | 77465585 | 77509993 | Rat | 123 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733786 | Eaf2 | ELL associated factor 2 | Predicted to enable transcription elongation factor activity. Acts upstream of or within negative regulation of cell growth; negative regulation of epithelial cell proliferation involved in prostate gland development; and positive regulation of DNA-templated transcription. Located in nucleoplasm. Is expressed in several structures, including genitourinary system; integumental system; nervous system; sensory organ; and tooth. Orthologous to human EAF2 (ELL associated factor 2). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 36613246 | 36695275 | Mouse | 139 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736664 | EAF2 | ELL associated factor 2 | Enables transcription elongation factor activity. Involved in positive regulation of transcription by RNA polymerase II and regulation of transcription elongation by RNA polymerase II. Part of transcription elongation factor complex. Biomarker of prostate cancer. [provided by Alliance of Genome Reso urces, Jul 2025] | 3 | 121835209 | 121886526 | Human | 124 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8935663 | Eaf2 | ELL associated factor 2 | ENCODES a protein that exhibits transcription elongation factor activity (ortholog); INVOLVED IN negative regulation of cell growth (ortholog); negative regulation of epithelial cell proliferation involved in prostate gland development (ortholog); positive regulation of DNA-templated transcription ( ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH B-cell lymphoma (ortholog); COVID-19 (ortholog); hepatocellular carcinoma (ortholog); FOUND IN nucleoplasm (ortholog); transcription elongation factor complex (ortholog) | NW_004955427 | 21171900 | 21204138 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11951182 | EAF2 | ELL associated factor 2 | ENCODES a protein that exhibits transcription elongation factor activity (inferred); INVOLVED IN negative regulation of cell growth (ortholog); negative regulation of epithelial cell proliferation involved in prostate gland development (ortholog); positive regulation of DNA-templated transcription ( ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH B-cell lymphoma (ortholog); COVID-19 (ortholog); hepatocellular carcinoma (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); super elongation complex (inferred) | 3 | 118936685 | 118996051 | Bonobo | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12170279 | EAF2 | ELL associated factor 2 | ENCODES a protein that exhibits transcription elongation factor activity (inferred); INVOLVED IN negative regulation of cell growth (ortholog); negative regulation of epithelial cell proliferation involved in prostate gland development (ortholog); positive regulation of DNA-templated transcription ( ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH B-cell lymphoma (ortholog); COVID-19 (ortholog); hepatocellular carcinoma (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); super elongation complex (inferred) | 33 | 25113348 | 25147064 | Dog | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12723091 | Eaf2 | ELL associated factor 2 | ENCODES a protein that exhibits transcription elongation factor activity (inferred); INVOLVED IN negative regulation of cell growth (ortholog); negative regulation of epithelial cell proliferation involved in prostate gland development (ortholog); positive regulation of DNA-templated transcription ( ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH B-cell lymphoma (ortholog); COVID-19 (ortholog); hepatocellular carcinoma (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); super elongation complex (inferred) | NW_004936536 | 8213794 | 8257595 | Squirrel | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626069874 | Eaf2 | ELL associated factor 2 | ENCODES a protein that exhibits transcription elongation factor activity (ortholog); INVOLVED IN negative regulation of cell growth (ortholog); negative regulation of epithelial cell proliferation involved in prostate gland development (ortholog); positive regulation of DNA-templated transcription ( ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH B-cell lymphoma (ortholog); COVID-19 (ortholog); hepatocellular carcinoma (ortholog); FOUND IN nucleoplasm (ortholog); transcription elongation factor complex (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18918538 | Eaf2 | ELL associated factor 2 | ENCODES a protein that exhibits transcription elongation factor activity (inferred); INVOLVED IN negative regulation of cell growth (ortholog); negative regulation of epithelial cell proliferation involved in prostate gland development (ortholog); positive regulation of DNA-templated transcription ( ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH B-cell lymphoma (ortholog); COVID-19 (ortholog); hepatocellular carcinoma (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); super elongation complex (inferred) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18516517 | EAF2 | ELL associated factor 2 | ENCODES a protein that exhibits transcription elongation factor activity (inferred); INVOLVED IN negative regulation of cell growth (ortholog); negative regulation of epithelial cell proliferation involved in prostate gland development (ortholog); positive regulation of DNA-templated transcription ( ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH B-cell lymphoma (ortholog); COVID-19 (ortholog); hepatocellular carcinoma (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); super elongation complex (inferred) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245269 | eaf2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14021347 | EAF2 | ELL associated factor 2 | ENCODES a protein that exhibits transcription elongation factor activity (inferred); INVOLVED IN negative regulation of cell growth (ortholog); negative regulation of epithelial cell proliferation involved in prostate gland development (ortholog); positive regulation of DNA-templated transcription ( ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH B-cell lymphoma (ortholog); COVID-19 (ortholog); hepatocellular carcinoma (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); super elongation complex (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245270 | eaf2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155255901 | eaf2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1322676 | DMAP1 | DNA methyltransferase 1 associated protein 1 | This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferas e 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] | 1 | 44213471 | 44220673 | Human | 93 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |