EAF2 (ELL associated factor 2) - Rat Genome Database

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Gene: EAF2 (ELL associated factor 2) Sus scrofa
Analyze
Symbol: EAF2
Name: ELL associated factor 2
RGD ID: 14021347
Description: ENCODES a protein that exhibits transcription elongation factor activity (inferred); INVOLVED IN epithelial cell proliferation involved in prostate gland development (ortholog); negative regulation of cell growth (ortholog); negative regulation of epithelial cell proliferation involved in prostate gland development (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH alkaptonuria (ortholog); B-cell lymphoma (ortholog); COVID-19 (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); super elongation complex (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ELL-associated factor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13138,648,270 - 138,681,613 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113138,632,541 - 138,681,607 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213148,259,076 - 148,308,649 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:30032202  


Genomics

Comparative Map Data
EAF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13138,648,270 - 138,681,613 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113138,632,541 - 138,681,607 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213148,259,076 - 148,308,649 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EAF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383121,835,209 - 121,886,526 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3121,835,183 - 121,886,526 (+)EnsemblGRCh38hg38GRCh38
GRCh373121,554,056 - 121,605,373 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363123,036,724 - 123,088,063 (+)NCBINCBI36Build 36hg18NCBI36
Build 343123,036,723 - 123,088,062NCBI
Celera3119,963,909 - 120,015,222 (+)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3118,928,117 - 118,979,418 (+)NCBIHuRef
CHM1_13121,517,515 - 121,569,414 (+)NCBICHM1_1
T2T-CHM13v2.03124,555,203 - 124,606,495 (+)NCBIT2T-CHM13v2.0
Eaf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391636,613,246 - 36,695,275 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1636,613,246 - 36,695,365 (-)EnsemblGRCm39 Ensembl
GRCm381636,792,884 - 36,875,068 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1636,792,884 - 36,875,003 (-)EnsemblGRCm38mm10GRCm38
MGSCv371636,792,970 - 36,874,912 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361636,712,123 - 36,794,065 (-)NCBIMGSCv36mm8
Celera1637,203,320 - 37,285,700 (-)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1626.05NCBI
Eaf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81177,465,585 - 77,509,993 (+)NCBIGRCr8
mRatBN7.21163,960,200 - 64,004,610 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1163,960,200 - 64,004,610 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1172,772,600 - 72,817,008 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01165,434,824 - 65,479,238 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,469,113 - 64,510,223 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01166,878,658 - 66,923,092 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,878,658 - 66,923,092 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01169,969,912 - 70,013,412 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41165,763,410 - 65,809,967 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11165,820,998 - 65,867,556 (+)NCBI
Celera1163,432,421 - 63,474,673 (+)NCBICelera
Cytogenetic Map11q21NCBI
Eaf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542721,172,009 - 21,204,051 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542721,171,900 - 21,204,138 (+)NCBIChiLan1.0ChiLan1.0
EAF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22119,791,502 - 119,842,980 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13119,796,280 - 119,847,758 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03118,936,685 - 118,996,051 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13125,844,338 - 125,895,416 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3125,844,338 - 125,895,416 (+)Ensemblpanpan1.1panPan2
EAF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13325,113,348 - 25,147,064 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3325,112,570 - 25,146,692 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3325,138,640 - 25,172,592 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03325,348,708 - 25,382,453 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3325,348,721 - 25,383,535 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13325,147,046 - 25,180,866 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03325,189,107 - 25,223,100 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03325,747,329 - 25,781,040 (+)NCBIUU_Cfam_GSD_1.0
Eaf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602129,264,251 - 129,308,212 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365368,213,763 - 8,258,201 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365368,213,794 - 8,257,595 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EAF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12258,966,640 - 59,025,158 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2258,974,409 - 59,025,143 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041107,296,606 - 107,348,595 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eaf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624912112,843 - 168,553 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624912112,793 - 168,553 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EAF2
954 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 2 5 2 2 1 3
Low 1 16 1
Below cutoff 1 1 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000012996   ⟹   ENSSSCP00000012654
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13138,637,086 - 138,681,577 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000083810   ⟹   ENSSSCP00000068948
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13138,648,270 - 138,681,568 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000084989   ⟹   ENSSSCP00000074356
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13138,648,270 - 138,681,613 (-)Ensembl
RefSeq Acc Id: XM_005654037   ⟹   XP_005654094
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113138,638,764 - 138,681,607 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013980937   ⟹   XP_013836391
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113138,632,541 - 138,681,602 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021070273   ⟹   XP_020925932
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113138,650,065 - 138,681,602 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_013836391   ⟸   XM_013980937
- Peptide Label: isoform X3
- UniProtKB: A0A4X1T734 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005654094   ⟸   XM_005654037
- Peptide Label: isoform X1
- UniProtKB: F1SQ18 (UniProtKB/TrEMBL),   A0A4X1T933 (UniProtKB/TrEMBL),   A0A8D0Y4W0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020925932   ⟸   XM_021070273
- Peptide Label: isoform X2
- UniProtKB: A0A8D0R8M9 (UniProtKB/TrEMBL),   A0A8D0U2A5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000068948   ⟸   ENSSSCT00000083810
RefSeq Acc Id: ENSSSCP00000074356   ⟸   ENSSSCT00000084989
RefSeq Acc Id: ENSSSCP00000012654   ⟸   ENSSSCT00000012996
Protein Domains
Transcription elongation factor Eaf N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011880 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015036107 UniProtKB/TrEMBL
  ENSSSCG00025023096 UniProtKB/TrEMBL
  ENSSSCG00030073226 UniProtKB/TrEMBL
  ENSSSCG00035076545 UniProtKB/TrEMBL
  ENSSSCG00040047470 UniProtKB/TrEMBL
  ENSSSCG00045022860 UniProtKB/TrEMBL
  ENSSSCG00050044095 UniProtKB/TrEMBL
  ENSSSCG00055012756 UniProtKB/TrEMBL
  ENSSSCG00060074747 UniProtKB/TrEMBL
  ENSSSCG00065068002 UniProtKB/TrEMBL
  ENSSSCG00070007410 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000084989 ENTREZGENE
  ENSSSCT00000084989.1 UniProtKB/TrEMBL
  ENSSSCT00015048522.1 UniProtKB/TrEMBL
  ENSSSCT00025031286.1 UniProtKB/TrEMBL
  ENSSSCT00030102537.1 UniProtKB/TrEMBL
  ENSSSCT00035104117.1 UniProtKB/TrEMBL
  ENSSSCT00040063907.1 UniProtKB/TrEMBL
  ENSSSCT00045038984.1 UniProtKB/TrEMBL
  ENSSSCT00045039077.1 UniProtKB/TrEMBL
  ENSSSCT00050060026.1 UniProtKB/TrEMBL
  ENSSSCT00055025375.1 UniProtKB/TrEMBL
  ENSSSCT00060102224.1 UniProtKB/TrEMBL
  ENSSSCT00065093365.1 UniProtKB/TrEMBL
  ENSSSCT00070014263.1 UniProtKB/TrEMBL
  ENSSSCT00070014271.1 UniProtKB/TrEMBL
  ENSSSCT00070014280.1 UniProtKB/TrEMBL
InterPro EAF_fam UniProtKB/TrEMBL
  Tscrpt_elong_fac_Eaf_N UniProtKB/TrEMBL
KEGG Report ssc:106504176 UniProtKB/TrEMBL
NCBI Gene EAF2 ENTREZGENE
PANTHER ELL-ASSOCIATED FACTOR 2 UniProtKB/TrEMBL
  PTHR15970 UniProtKB/TrEMBL
Pfam EAF UniProtKB/TrEMBL
UniProt A0A4X1T734 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T933 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TAJ2_PIG UniProtKB/TrEMBL
  A0A5G2RD18_PIG UniProtKB/TrEMBL
  A0A8D0R8M9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0U2A5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Y4W0 ENTREZGENE, UniProtKB/TrEMBL
  F1SQ18 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:87522 ENTREZGENE