| 1308477 | Drap1 | Dr1 associated protein 1 | ENCODES a protein that exhibits DNA binding (ortholog); identical protein binding (ortholog); RNA polymerase II general transcription initiation factor activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH melanoma (ortholog); FOUND IN nucleus (ortholog); RNA polymerase II transcription regulator complex (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene | 1 | 212161107 | 212163833 | Rat | 107 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1318268 | DRAP1 | DR1 associated protein 1 | Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II an d general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008] | 11 | 65919426 | 65921563 | Human | 111 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1318269 | Drap1 | DR1 associated protein 1 | Enables transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; and limb. Orthologous to human DRAP1 P1 (DR1 associated protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 5472832 | 5475007 | Mouse | 107 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8738656 | Drap1 | DR1 associated protein 1 | ENCODES a protein that exhibits DNA binding (ortholog); identical protein binding (ortholog); RNA polymerase II general transcription initiation factor activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH melanoma (ortholog); FOUND IN nucleus (ortholog); RNA polymerase II transcription regulator complex (ortholog) | NW_004955422 | 19406106 | 19408232 | Chinchilla | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11959262 | DRAP1 | DR1 associated protein 1 | ENCODES a protein that exhibits transcription corepressor activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH melanoma (ortholog); FOUND IN negative cofactor 2 complex (inferred); nucleus (inferred); RNA polymerase II transcription r egulator complex (inferred) | 11 | 61279681 | 61281881 | Bonobo | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12224537 | DRAP1 | DR1 associated protein 1 | ENCODES a protein that exhibits transcription corepressor activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH melanoma (ortholog); FOUND IN nucleus (inferred); RNA polymerase II transcription regulator complex (inferred) | 18 | 51350625 | 51352742 | Dog | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12539936 | Drap1 | DR1 associated protein 1 | ENCODES a protein that exhibits transcription corepressor activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH melanoma (ortholog); FOUND IN nucleus (ortholog) | NW_004936599 | 3621549 | 3622824 | Squirrel | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247562 | drap1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18652264 | DRAP1 | DR1 associated protein 1 | ENCODES a protein that exhibits transcription corepressor activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH melanoma (ortholog); FOUND IN negative cofactor 2 complex (inferred); nucleus (inferred); RNA polymerase II transcription r egulator complex (inferred) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13953709 | DRAP1 | DR1 associated protein 1 | ENCODES a protein that exhibits transcription corepressor activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH melanoma (ortholog); FOUND IN nucleus (inferred); RNA polymerase II transcription regulator complex (inferred) | | | | Pig | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18903263 | Drap1 | DR1 associated protein 1 | ENCODES a protein that exhibits DNA binding (ortholog); identical protein binding (ortholog); RNA polymerase II general transcription initiation factor binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH melanoma (ortholog); FOUND IN RNA polymerase II transcription regulator complex (ortholog) | | | | Naked Mole-Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626056214 | Drap1 | DR1 associated protein 1 | ENCODES a protein that exhibits DNA binding (ortholog); identical protein binding (ortholog); RNA polymerase II general transcription initiation factor activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH melanoma (ortholog); FOUND IN nucleus (ortholog); RNA polymerase II transcription regulator complex (ortholog) | | | | Black Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258504 | drap1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155256875 | drap1.S | | | | | | African Clawed Frog | | symbol | gene, null |
