| 1348882 | DDX3Y | DEAD-box helicase 3 Y-linked | The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular inter actions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome. Pseudogenes sharing similarity to both this gene and the DDX3X paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014] | Y | 12903999 | 12920478 | Human | 126 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1616820 | Ddx3y | DEAD box helicase 3, Y-linked | Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in cell differentiation; gamete generation; and negative regulation of gene expression. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in P granule and nucleus. Is expressed in s everal structures, including heart; hemolymphoid system gland; liver; lung; and reproductive system. Orthologous to human DDX3Y (DEAD-box helicase 3 Y-linked). [provided by Alliance of Genome Resources, Apr 2025] | Y | 1260715 | 1286630 | Mouse | 114 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 2314437 | Ddx3y | DEAD box helicase 3, Y-linked | ENCODES a protein that exhibits ATP binding (inferred); helicase activity (inferred); hydrolase activity (inferred); PARTICIPATES IN Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; ASSOCIATED WITH spermatogenic failure 3 (ortholog); Y-linked spermatogenic failure 2 (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran; acetamide | Y | 1190042 | 1210699 | Rat | 108 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 329331095 | DDX3Y | DEAD-box helicase 3 Y-linked | ENCODES a protein that exhibits ATP binding (inferred); helicase activity (inferred); hydrolase activity (inferred); ASSOCIATED WITH spermatogenic failure 3 (ortholog); Y-linked spermatogenic failure 2 (ortholog); FOUND IN cytosol (ortholog) | | | | Bonobo | 13 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1309586 | Ddx3 | DEAD-box helicase 3 | ENCODES a protein that exhibits ATP binding (inferred); helicase activity (inferred); hydrolase activity (inferred); PARTICIPATES IN Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH dimethylarsinic acid | 13 | 101051975 | 101055144 | Rat | 18 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14017246 | LOC100624590 | ATP-dependent RNA helicase DDX3X | ENCODES a protein that exhibits ATP binding (inferred); helicase activity (inferred); hydrolase activity (inferred); ASSOCIATED WITH spermatogenic failure 3 (ortholog); Y-linked spermatogenic failure 2 (ortholog); FOUND IN cytosol (ortholog) | | | | Pig | 20 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 40907658 | LOC119868757 | ATP-dependent RNA helicase DDX3X-like | ENCODES a protein that exhibits ATP binding (inferred); helicase activity (inferred); hydrolase activity (inferred) | | | | Dog | 16 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18925957 | LOC101704012 | ATP-dependent RNA helicase DDX3Y-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18929065 | LOC101716347 | ATP-dependent RNA helicase DDX3Y-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18464431 | LOC103232207 | ATP-dependent RNA helicase DDX3Y-like | | | | | Green Monkey | | name | gene, pseudo, MODEL [RefSeq] |
| 626087692 | LOC116889595 | ATP-dependent RNA helicase DDX3Y-like | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 18927719 | LOC101711814 | ATP-dependent RNA helicase DDX3X | ENCODES a protein that exhibits ATP binding (inferred); helicase activity (inferred); hydrolase activity (inferred) | | | | Naked Mole-Rat | 9 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 5133406 | DDX3P1 | DEAD-box helicase 3 pseudogene 1 | | X | 74121043 | 74139454 | Human | | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 6480925 | DDX3P2 | DEAD-box helicase 3 pseudogene 2 | | X | 74133004 | 74133114 | Human | | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 5133408 | DDX3P3 | DEAD-box helicase 3 pseudogene 3 | | 4 | 103572002 | 103576529 | Human | | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1352934 | DDX3X | DEAD-box helicase 3 X-linked | The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, an d unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] | X | 41333308 | 41364472 | Human | 518 | description | gene, protein-coding, REVIEWED [RefSeq] |
