| 1349899 | DCTD | dCMP deaminase | The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two tran script variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 4 | 182890091 | 182917611 | Human | 102 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1359671 | Dctd | dCMP deaminase | ENCODES a protein that exhibits 5-hydroxymethyl-dUMP N-hydrolase activity (ortholog); identical protein binding (ortholog); INVOLVED IN nucleoside salvage (ortholog); PARTICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; gemcitabine pharmacodynamics pathwa y; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide | 16 | 50799699 | 50831398 | Rat | 102 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1553363 | Dctd | dCMP deaminase | Predicted to enable 5-hydroxymethyl-dUMP N-hydrolase activity; dCMP deaminase activity; and identical protein binding activity. Predicted to be involved in nucleobase-containing small molecule metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including alime ntary system; cranium; integumental system; nervous system; and respiratory system. Orthologous to human DCTD (dCMP deaminase). [provided by Alliance of Genome Resources, Apr 2025] | 8 | 48552127 | 48594702 | Mouse | 105 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8795588 | Dctd | dCMP deaminase | ENCODES a protein that exhibits 5-hydroxymethyl-dUMP N-hydrolase activity (ortholog); identical protein binding (ortholog); INVOLVED IN nucleoside salvage (ortholog); PARTICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; gemcitabine pharmacodynamics pathwa y | NW_004955403 | 25825366 | 25849511 | Chinchilla | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12003411 | DCTD | dCMP deaminase | ENCODES a protein that exhibits 5-hydroxymethyl-dUMP N-hydrolase activity (inferred); catalytic activity (inferred); dCMP deaminase activity (inferred); INVOLVED IN nucleoside salvage (inferred); nucleotide biosynthetic process (inferred); pyrimidine nucleotide metabolic process (inferred); PARTICIP ATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; gemcitabine pharmacodynamics pathway; FOUND IN cytoplasm (inferred) | 4 | 175079416 | 175106756 | Bonobo | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12494542 | Dctd | dCMP deaminase | ENCODES a protein that exhibits 5-hydroxymethyl-dUMP N-hydrolase activity (inferred); catalytic activity (inferred); dCMP deaminase activity (inferred); INVOLVED IN nucleoside salvage (inferred); nucleotide biosynthetic process (inferred); pyrimidine nucleotide metabolic process (inferred); PARTICIP ATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; gemcitabine pharmacodynamics pathway; FOUND IN cytoplasm (inferred) | NW_004936554 | 6088544 | 6110274 | Squirrel | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 40915501 | DCTD | dCMP deaminase | ENCODES a protein that exhibits 5-hydroxymethyl-dUMP N-hydrolase activity (inferred); catalytic activity (inferred); dCMP deaminase activity (inferred); INVOLVED IN nucleoside salvage (inferred); nucleotide biosynthetic process (inferred); pyrimidine nucleotide metabolic process (inferred); PARTICIP ATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; gemcitabine pharmacodynamics pathway | 16 | 47350493 | 47376184 | Dog | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18929530 | Dctd | dCMP deaminase | ENCODES a protein that exhibits 5-hydroxymethyl-dUMP N-hydrolase activity (ortholog); identical protein binding (ortholog); INVOLVED IN nucleoside salvage (ortholog); PARTICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; gemcitabine pharmacodynamics pathwa y; FOUND IN cytoplasm (inferred) | | | | Naked Mole-Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626085964 | Dctd | dCMP deaminase | ENCODES a protein that exhibits 5-hydroxymethyl-dUMP N-hydrolase activity (ortholog); identical protein binding (ortholog); INVOLVED IN nucleoside salvage (ortholog); PARTICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; gemcitabine pharmacodynamics pathwa y | | | | Black Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155253979 | dctd | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18720842 | DCTD | dCMP deaminase | ENCODES a protein that exhibits 5-hydroxymethyl-dUMP N-hydrolase activity (inferred); catalytic activity (inferred); dCMP deaminase activity (inferred); INVOLVED IN nucleoside salvage (inferred); nucleotide biosynthetic process (inferred); PARTICIPATES IN beta-ureidopropionase deficiency pathway; di hydropyrimidinase deficiency pathway; gemcitabine pharmacodynamics pathway; FOUND IN cytoplasm (inferred) | | | | Green Monkey | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13906489 | DCTD | dCMP deaminase | ENCODES a protein that exhibits 5-hydroxymethyl-dUMP N-hydrolase activity (inferred); catalytic activity (inferred); dCMP deaminase activity (inferred); INVOLVED IN nucleoside salvage (inferred); nucleotide biosynthetic process (inferred); pyrimidine nucleotide metabolic process (inferred); PARTICIP ATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; gemcitabine pharmacodynamics pathway | | | | Pig | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155253980 | dctd.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 2323302 | Dctd-ps1 | dCMP deaminase, pseudogene 1 | | 3 | 77924565 | 77928183 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 2320547 | Dctd-ps2 | dCMP deaminase, pseudogene 2 | | X | 67543459 | 67543987 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |