| 1308513 | Dcaf8 | DDB1 and CUL4 associated factor 8 | INVOLVED IN myotube cell development (ortholog); ASSOCIATED WITH giant axonal neuropathy 2 (ortholog); neurofibromatosis 1 (ortholog); FOUND IN Cul4-RING E3 ubiquitin ligase complex (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 17beta-estradiol; amiodarone; amitriptyline | 13 | 87141940 | 87199859 | Rat | 106 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1349472 | DCAF8 | DDB1 and CUL4 associated factor 8 | This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009] | 1 | 160215720 | 160262549 | Human | 124 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1619059 | Dcaf8 | DDB1 and CUL4 associated factor 8 | Acts upstream of or within myotube cell development. Part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in several structures, including cerebral cortex; liver; lung; metanephros; and spleen. Human ortholog(s) of this gene implicated in giant axonal neuropathy 2. Orthologous to human DCAF8 style='font-weight:700;'>DCAF8 (DDB1 and CUL4 associated factor 8). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 171975574 | 172023959 | Mouse | 123 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8892238 | Dcaf8 | DDB1 and CUL4 associated factor 8 | INVOLVED IN myotube cell development (ortholog); ASSOCIATED WITH giant axonal neuropathy 2 (ortholog); neurofibromatosis 1 (ortholog); FOUND IN Cul4-RING E3 ubiquitin ligase complex (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955468 | 11991779 | 12037541 | Chinchilla | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11850546 | DCAF8 | DDB1 and CUL4 associated factor 8 | INVOLVED IN myotube cell development (ortholog); ASSOCIATED WITH giant axonal neuropathy 2 (ortholog); neurofibromatosis 1 (ortholog); FOUND IN Cul4-RING E3 ubiquitin ligase complex (inferred); cytoplasm (inferred); cytosol (inferred) | 1 | 135569736 | 135616614 | Bonobo | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12213721 | DCAF8 | DDB1 and CUL4 associated factor 8 | INVOLVED IN myotube cell development (ortholog); ASSOCIATED WITH giant axonal neuropathy 2 (ortholog); neurofibromatosis 1 (ortholog); FOUND IN Cul4-RING E3 ubiquitin ligase complex (inferred); cytoplasm (inferred); cytosol (inferred) | 38 | 21959228 | 22001388 | Dog | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12465957 | Dcaf8 | DDB1 and CUL4 associated factor 8 | INVOLVED IN myotube cell development (ortholog); ASSOCIATED WITH giant axonal neuropathy 2 (ortholog); neurofibromatosis 1 (ortholog); FOUND IN Cul4-RING E3 ubiquitin ligase complex (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936740 | 368795 | 415997 | Squirrel | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18915632 | Dcaf8 | DDB1 and CUL4 associated factor 8 | INVOLVED IN myotube cell development (ortholog); ASSOCIATED WITH giant axonal neuropathy 2 (ortholog); neurofibromatosis 1 (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Naked Mole-Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625989339 | Dcaf8 | DDB1 and CUL4 associated factor 8 | INVOLVED IN myotube cell development (ortholog); ASSOCIATED WITH giant axonal neuropathy 2 (ortholog); neurofibromatosis 1 (ortholog); FOUND IN Cul4-RING E3 ubiquitin ligase complex (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18579638 | DCAF8 | DDB1 and CUL4 associated factor 8 | INVOLVED IN myotube cell development (ortholog); ASSOCIATED WITH giant axonal neuropathy 2 (ortholog); neurofibromatosis 1 (ortholog); FOUND IN Cul4-RING E3 ubiquitin ligase complex (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233080 | dcaf8 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14090294 | DCAF8 | DDB1 and CUL4 associated factor 8 | INVOLVED IN myotube cell development (ortholog); ASSOCIATED WITH giant axonal neuropathy 2 (ortholog); neurofibromatosis 1 (ortholog); FOUND IN Cul4-RING E3 ubiquitin ligase complex (inferred); cytoplasm (inferred); cytosol (inferred); INTERACTS WITH ammonia | | | | Pig | 25 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155233081 | dcaf8.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16554166 | DCAF8-DT | DCAF8 divergent transcript | INVOLVED IN SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition (inferred); FOUND IN signal recognition particle, endoplasmic reticulum targeting (inferred) | 1 | 160261749 | 160262778 | Human | 2 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1590921 | Dcaf8-ps1 | DDB1- and CUL4-associated factor 8, pseudogene 1 | | 1 | 155990284 | 155991985 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1557056 | Dcaf8l | DDB1 and CUL4 associated factor 8 like | Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human DCAF8L1 (DDB1 and CUL4 associated factor 8 like 1) and DCAF8L2 (DDB1 and CUL4 associated factor 8 like 2). [provided by Alliance of Genome Resources, Jul 2025] | X | 88447454 | 88453295 | Mouse | 23 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1346743 | DCAF8L1 | DDB1 and CUL4 associated factor 8 like 1 | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate the formation of heterotrimeric or multi-protein complexes. Members of this family are invol ved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 1. However, the CDS of this intronless gene remains intact, it is conserved in other primate species, it is known to be transcribed, and it is therefore thought to encode a functional protein. [provided by RefSeq, May 2010] | X | 27977992 | 27981449 | Human | 7 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1584985 | Dcaf8l1 | DDB1 and CUL4 associated factor 8-like 1 | INVOLVED IN protein ubiquitination (inferred); INTERACTS WITH benzo[a]pyrene (ortholog); CGP 52608 (ortholog); valproic acid (ortholog) | X | 58458683 | 58462949 | Rat | 7 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 11892524 | DCAF8L1 | DDB1 and CUL4 associated factor 8 like 1 | FOUND IN Cul4-RING E3 ubiquitin ligase complex (inferred); cytoplasm (inferred) | X | 20579088 | 20580938 | Bonobo | 3 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 15003261 | Dcaf8l1 | DDB1 and CUL4 associated factor 8-like 1 | | | | | Rat | | symbol , PhenoGen | gene, processed_pseudogene |
| 18485278 | DCAF8L1 | DDB1 and CUL4 associated factor 8 like 1 | | | | | Green Monkey | | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1342776 | DCAF8L2 | DDB1 and CUL4 associated factor 8 like 2 | Predicted to be located in nucleus. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025] | X | 27468941 | 27749942 | Human | 20 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 11734873 | DCAF8L2 | DDB1 and CUL4 associated factor 8 like 2 | FOUND IN Cul4-RING E3 ubiquitin ligase complex (inferred); cytoplasm (inferred) | X | 20185802 | 20349078 | Bonobo | 3 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18785049 | DCAF8L2 | DDB1 and CUL4 associated factor 8 like 2 | FOUND IN Cul4-RING E3 ubiquitin ligase complex (inferred); cytoplasm (inferred) | | | | Green Monkey | 3 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12388640 | LOC491793 | DDB1- and CUL4-associated factor 8 | FOUND IN Cul4-RING E3 ubiquitin ligase complex (inferred) | X | 22924453 | 22927232 | Dog | 3 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
