| 1348421 | DACT1 | dishevelled binding antagonist of beta catenin 1 | The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012] | 14 | 58634061 | 58648321 | Human | 287 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1564008 | Dact1 | dishevelled-binding antagonist of beta-catenin 1 | ENCODES a protein that exhibits beta-catenin binding (ortholog); delta-catenin binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); dendrite morphogenesis (ortholog); embryonic hindgut morphogenesis (ortholog); ASSOCIATED WITH Axenfeld-R ieger syndrome (ortholog); Colorectal Neoplasms (ortholog); Townes-Brocks syndrome (ortholog); FOUND IN beta-catenin destruction complex (ortholog); cytoplasm (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil | 6 | 95526645 | 95538625 | Rat | 193 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1620056 | Dact1 | dishevelled-binding antagonist of beta-catenin 1 | Enables delta-catenin binding activity; protein kinase A binding activity; and protein kinase C binding activity. Involved in several processes, including embryonic hindgut morphogenesis; negative regulation of JNK cascade; and regulation of Wnt signaling pathway. Acts upstream of or within several processes, including dendrite morphogenesis; negative regulation of canonical Wnt signaling pathway; and positive regulation of fat cell differentiation. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and genitourinary system. Human ortholog(s) of this gene implicated in Townes-Brocks syndrome. Orthologous to human DACT1 (dishevelled binding antagonist of beta catenin 1). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 71356658 | 71366881 | Mouse | 295 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8847609 | Dact1 | dishevelled binding antagonist of beta catenin 1 | ENCODES a protein that exhibits beta-catenin binding (ortholog); delta-catenin binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); dendrite morphogenesis (ortholog); embryonic hindgut morphogenesis (ortholog); ASSOCIATED WITH Axenfeld-R ieger syndrome (ortholog); Colorectal Neoplasms (ortholog); Townes-Brocks syndrome (ortholog); FOUND IN beta-catenin destruction complex (ortholog); cytoplasm (ortholog); glutamatergic synapse (ortholog) | NW_004955466 | 12367760 | 12374141 | Chinchilla | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11947907 | DACT1 | dishevelled binding antagonist of beta catenin 1 | ENCODES a protein that exhibits delta-catenin binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); dendrite morphogenesis (ortholog); embryonic hindgut morphogenesis (ortholog); ASSOCIATED WITH Axenfeld-Rieger syndrome (ortholog); Colorecta l Neoplasms (ortholog); Townes-Brocks syndrome (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynapse (ortholog) | 14 | 39231910 | 39242353 | Bonobo | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12151579 | DACT1 | dishevelled binding antagonist of beta catenin 1 | ENCODES a protein that exhibits delta-catenin binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); dendrite morphogenesis (ortholog); embryonic hindgut morphogenesis (ortholog); ASSOCIATED WITH Axenfeld-Rieger syndrome (ortholog); Colorecta l Neoplasms (ortholog); Townes-Brocks syndrome (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynapse (ortholog) | 8 | 33950016 | 33959671 | Dog | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12618913 | Dact1 | dishevelled binding antagonist of beta catenin 1 | ENCODES a protein that exhibits delta-catenin binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); dendrite morphogenesis (ortholog); embryonic hindgut morphogenesis (ortholog); ASSOCIATED WITH Axenfeld-Rieger syndrome (ortholog); Colorecta l Neoplasms (ortholog); Townes-Brocks syndrome (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynapse (ortholog) | NW_004936495 | 3017029 | 3026759 | Squirrel | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14118762 | DACT1 | dishevelled binding antagonist of beta catenin 1 | ENCODES a protein that exhibits delta-catenin binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); dendrite morphogenesis (ortholog); embryonic hindgut morphogenesis (ortholog); ASSOCIATED WITH Axenfeld-Rieger syndrome (ortholog); Colorecta l Neoplasms (ortholog); Townes-Brocks syndrome (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynapse (ortholog); INTERACTS WITH deoxynivalenol; resveratrol | | | | Pig | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155231326 | dact1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626130753 | Dact1 | dishevelled binding antagonist of beta catenin 1 | ENCODES a protein that exhibits beta-catenin binding (ortholog); delta-catenin binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); dendrite morphogenesis (ortholog); embryonic hindgut morphogenesis (ortholog); ASSOCIATED WITH Axenfeld-R ieger syndrome (ortholog); Colorectal Neoplasms (ortholog); Townes-Brocks syndrome (ortholog); FOUND IN beta-catenin destruction complex (ortholog); cytoplasm (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18536583 | DACT1 | dishevelled binding antagonist of beta catenin 1 | ENCODES a protein that exhibits delta-catenin binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); dendrite morphogenesis (ortholog); embryonic hindgut morphogenesis (ortholog); ASSOCIATED WITH Axenfeld-Rieger syndrome (ortholog); Colorecta l Neoplasms (ortholog); Townes-Brocks syndrome (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynapse (ortholog) | | | | Green Monkey | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18922220 | Dact1 | dishevelled binding antagonist of beta catenin 1 | ENCODES a protein that exhibits beta-catenin binding (ortholog); delta-catenin binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN canonical Wnt signaling pathway (ortholog); dendrite morphogenesis (ortholog); embryonic hindgut morphogenesis (ortholog); ASSOCIATED WITH Axenfeld-R ieger syndrome (ortholog); Colorectal Neoplasms (ortholog); Townes-Brocks syndrome (ortholog); FOUND IN beta-catenin destruction complex (ortholog); glutamatergic synapse (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249752 | dact1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155231325 | dact1.S | | | | | | African Clawed Frog | | symbol | gene, null |