| 1310755 | Cxxc1 | CXXC finger protein 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding; histone H3K4me3 reader activity (ortholog); unmethylated CpG binding (ortholog); INVOLVED IN positive regulation of DNA-templated transcription (ortholog); regulation of DNA-templated transcription (ortholog); PARTI CIPATES IN DNA modification pathway; histone modification pathway; FOUND IN histone methyltransferase complex (ortholog); nuclear matrix (ortholog); nuclear speck (ortholog); INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; cadmium dichloride | 18 | 70088407 | 70093786 | Rat | 108 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1321844 | CXXC1 | CXXC finger protein 1 | This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 201 5] | 18 | 50282347 | 50287692 | Human | 104 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1321845 | Cxxc1 | CXXC finger protein 1 | Enables methylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Located in nuclear matrix. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and retina. Orthologous to human CXXC1 (CXXC finger protein 1). [provided by Alliance of Genome Resources, Apr 2025] | 18 | 74349283 | 74354564 | Mouse | 128 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8769096 | Cxxc1 | CXXC finger protein 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); histone H3K4me3 reader activity (ortholog); unmethylated CpG binding (ortholog); INVOLVED IN positive regulation of DNA-templated transcription (ortholog); regulation of DNA-templated transcription (ortho log); PARTICIPATES IN DNA modification pathway; histone modification pathway; FOUND IN histone methyltransferase complex (ortholog); nuclear matrix (ortholog); nuclear speck (ortholog) | NW_004955402 | 35335520 | 35340891 | Chinchilla | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11947243 | CXXC1 | CXXC finger protein 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN chromatin organization (inferred); DNA-templated transcription (inferred); positive regulation of DNA-templated transcription (inferred); PARTICIPATES IN DNA modification pathway; histone modi fication pathway; FOUND IN histone methyltransferase complex (inferred); nuclear lumen (inferred); nuclear matrix (inferred) | 18 | 43662843 | 43668825 | Bonobo | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12316669 | CXXC1 | CXXC finger protein 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); histone H3K4me3 reader activity (ortholog); unmethylated CpG binding (ortholog); INVOLVED IN regulation of DNA-templated transcription (ortholog); PARTICIPATES IN DNA modification pathway; histone modific ation pathway; FOUND IN histone methyltransferase complex (ortholog); nuclear matrix (ortholog); nuclear speck (ortholog) | 7 | 78591288 | 78596642 | Dog | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12534858 | Cxxc1 | CXXC finger protein 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN chromatin organization (inferred); DNA-templated transcription (inferred); positive regulation of DNA-templated transcription (inferred); PARTICIPATES IN DNA modification pathway; histone modi fication pathway; FOUND IN histone methyltransferase complex (inferred); nuclear lumen (inferred); nuclear matrix (inferred) | NW_004936497 | 12842569 | 12847952 | Squirrel | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14078864 | CXXC1 | CXXC finger protein 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN chromatin organization (inferred); DNA-templated transcription (inferred); positive regulation of DNA-templated transcription (inferred); PARTICIPATES IN DNA modification pathway; histone modi fication pathway; FOUND IN histone methyltransferase complex (inferred); nuclear lumen (inferred); nuclear matrix (inferred) | | | | Pig | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18557898 | CXXC1 | CXXC finger protein 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN chromatin organization (inferred); DNA-templated transcription (inferred); positive regulation of DNA-templated transcription (inferred); PARTICIPATES IN DNA modification pathway; histone modi fication pathway; FOUND IN histone methyltransferase complex (inferred); nuclear lumen (inferred); nuclear matrix (inferred) | | | | Green Monkey | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18917548 | Cxxc1 | CXXC finger protein 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); histone H3K4me3 reader activity (ortholog); unmethylated CpG binding (ortholog); INVOLVED IN regulation of DNA-templated transcription (ortholog); PARTICIPATES IN DNA modification pathway; histone modific ation pathway; FOUND IN histone methyltransferase complex (ortholog); nuclear matrix (ortholog); nuclear speck (ortholog) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155233752 | cxxc1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626089364 | Cxxc1 | CXXC finger protein 1 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); histone H3K4me3 reader activity (ortholog); unmethylated CpG binding (ortholog); INVOLVED IN positive regulation of DNA-templated transcription (ortholog); regulation of DNA-templated transcription (ortho log); PARTICIPATES IN DNA modification pathway; histone modification pathway; FOUND IN histone methyltransferase complex (ortholog); nuclear matrix (ortholog); nuclear speck (ortholog) | | | | Black Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626176776 | cxxc1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155240561 | cxxc1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1348142 | CXXC1P1 | CXXC finger protein 1 pseudogene 1 | INTERACTS WITH bisphenol F; fulvestrant | X | 47707191 | 47736628 | Human | 2 | symbol , COSMIC , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 1322203 | FBXL19 | F-box and leucine rich repeat protein 19 | This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflamm ation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] | 16 | 30922851 | 30948783 | Human | 58 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1605411 | KMT2B | lysine methyltransferase 2B | This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the ML L (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008] | 19 | 35718003 | 35738878 | Human | 259 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1606110 | RTP5 | receptor transporter protein 5 (putative) | Predicted to enable olfactory receptor binding activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of bitter taste; protein insertion into membrane; and protein targeting to membrane. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 241869729 | 241873823 | Human | 14 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8949870 | Rtp5 | receptor transporter protein 5 (putative) | | NW_004955542 | 40344 | 43885 | Chinchilla | 3 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12409325 | RTP5 | receptor transporter protein 5 (putative) | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); FOUND IN membrane (inferred) | 25 | 51625156 | 51628670 | Dog | 10 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12455334 | Rtp5 | receptor transporter protein 5 (putative) | ENCODES a protein that exhibits metal ion binding (inferred); olfactory receptor binding (inferred); zinc ion binding (inferred); INVOLVED IN detection of chemical stimulus involved in sensory perception of bitter taste (inferred); protein insertion into membrane (inferred); protein targeting to mem brane (inferred); FOUND IN membrane (inferred) | NW_004936745 | 143541 | 146508 | Squirrel | 10 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18928861 | Rtp5 | receptor transporter protein 5 (putative) | ENCODES a protein that exhibits metal ion binding (inferred); olfactory receptor binding (inferred); zinc ion binding (inferred); INVOLVED IN detection of chemical stimulus involved in sensory perception of bitter taste (inferred); protein insertion into membrane (inferred); protein targeting to mem brane (inferred); FOUND IN membrane (inferred) | | | | Naked Mole-Rat | 10 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |