| 2413 | Cryaa | crystallin, alpha A | ENCODES a protein that exhibits identical protein binding; structural molecule activity (ortholog); unfolded protein binding (ortholog); INVOLVED IN lens development in camera-type eye; protein folding; response to glucocorticoid; PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; ASSOCIATED WITH cataract; galactosemia; ocular hypertension; FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH (R)-lipoic acid; (R,R,R)-alpha-tocopherol; 5-azacytidine | 20 | 9784872 | 9788656 | Rat | 150 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10399 | Cryaa | crystallin, alpha A | This gene encodes subunit a, one of two subunits of alpha-crystallin, which is a high molecular weight, soluble aggregate and is a member of the small heat shock protein (sHSP) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically d istinct functions. It acts as a molecular chaperone and is the major protein in the eye lens, maintaining the transparency and refractive index of the lens. In mouse, deficiency in this gene is associated with smaller lenses and eyes and with increasing lens opacity with age. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] | 17 | 31896905 | 31900704 | Mouse | 170 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 735272 | CRYAA | crystallin alpha A | Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. Th ey act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq, Jan 2014] | 21 | 43169008 | 43172810 | Human | 214 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9024704 | Cryaa | crystallin alpha A | ENCODES a protein that exhibits identical protein binding (ortholog); structural molecule activity (ortholog); unfolded protein binding (ortholog); INVOLVED IN actin filament organization (ortholog); apoptotic process (ortholog); apoptotic process involved in morphogenesis (ortholog); ASSOCIATED WIT H autoimmune disease (ortholog); cataract (ortholog); cataract 9 multiple types (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | NW_004955407 | 38880088 | 38892946 | Chinchilla | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12023631 | CRYAA | crystallin alpha A | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN actin filament organization (ortholog); apoptotic process (ortholog); apoptotic process involved in morphogenesis (ortholog); ASSOCIATED WITH autoimmune disease (ortholog); cataract (ortholog); cataract 9 multiple type s (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 21 | 29414308 | 29480655 | Bonobo | 83 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12246728 | CRYAA | crystallin alpha A | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN actin filament organization (ortholog); apoptotic process (ortholog); apoptotic process involved in morphogenesis (ortholog); ASSOCIATED WITH autoimmune disease (ortholog); cataract (ortholog); cataract 9 multiple type s (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | 31 | 37307070 | 37310262 | Dog | 84 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12632869 | Cryaa | crystallin alpha A | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN actin filament organization (ortholog); apoptotic process (ortholog); apoptotic process involved in morphogenesis (ortholog); ASSOCIATED WITH autoimmune disease (ortholog); cataract (ortholog); cataract 9 multiple type s (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | NW_004936500 | 931804 | 935185 | Squirrel | 84 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18916557 | Cryaa | crystallin alpha A | ENCODES a protein that exhibits identical protein binding (ortholog); structural molecule activity (ortholog); INVOLVED IN actin filament organization (ortholog); apoptotic process (ortholog); apoptotic process involved in morphogenesis (ortholog); ASSOCIATED WITH autoimmune disease (ortholog); cata ract (ortholog); cataract 9 multiple types (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); protein-containing complex (ortholog) | | | | Naked Mole-Rat | 79 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625940842 | Cryaa | crystallin alpha A | ENCODES a protein that exhibits identical protein binding (ortholog); structural molecule activity (ortholog); unfolded protein binding (ortholog); INVOLVED IN actin filament organization (ortholog); apoptotic process (ortholog); apoptotic process involved in morphogenesis (ortholog); ASSOCIATED WIT H autoimmune disease (ortholog); cataract (ortholog); cataract 9 multiple types (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18772278 | CRYAA | crystallin alpha A | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN actin filament organization (ortholog); apoptotic process (ortholog); apoptotic process involved in morphogenesis (ortholog); ASSOCIATED WITH autoimmune disease (ortholog); cataract (ortholog); cataract 9 multiple type s (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 83 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244031 | cryaa | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14121550 | CRYAA | crystallin alpha A | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN actin filament organization (ortholog); apoptotic process (ortholog); apoptotic process involved in morphogenesis (ortholog); ASSOCIATED WITH autoimmune disease (ortholog); cataract (ortholog); cataract 9 multiple type s (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | | | | Pig | 84 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405864267 | cryaa.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626182733 | cryaa.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861309 | cryaa.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626182837 | cryaa.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859579 | cryaa.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859156 | cryaa.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155239458 | cryaa.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 13440456 | CRYAA2 | crystallin alpha A2 | ENCODES a protein that exhibits identical protein binding; structural molecule activity; unfolded protein binding; INVOLVED IN negative regulation of apoptotic process; negative regulation of intracellular transport; protein stabilization; FOUND IN cytoplasm; cytosol; nucleoplasm | 21 | 6499203 | 6564489 | Human | 43 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
