CRYAA2 (crystallin alpha A2) - Rat Genome Database

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Gene: CRYAA2 (crystallin alpha A2) Homo sapiens
Analyze
No known orthologs.
Symbol: CRYAA2 (Ensembl: CRYAA)
Name: crystallin alpha A2 (Ensembl:crystallin alpha A)
RGD ID: 13440456
Description: ENCODES a protein that exhibits identical protein binding; structural molecule activity; unfolded protein binding; INVOLVED IN negative regulation of apoptotic process; negative regulation of intracellular transport; protein stabilization; FOUND IN cytoplasm; cytosol; nucleoplasm
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-crystallin A chain; alpha-crystallin A2 chain; CRYAA
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: GeneID:102724652 is on a scaffold that is thought to be a false duplication and thus this gene is likely redundant with GeneID:1409. [11 Jun 2021]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38216,499,203 - 6,564,489 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2143,169,008 - 43,172,805 (+)EnsemblGRCh38hg38GRCh38
Cytogenetic Map21p12NCBI
CHM1_12144,149,991 - 44,153,755 (+)NCBICHM1_1
T2T-CHM13v2.02141,498,596 - 41,563,900 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IDA,IEA)
cytosol  (IDA)
nucleoplasm  (IDA)
nucleus  (IBA,IDA,IEA)
protein-containing complex  (IDA)

Molecular Function

References
Additional References at PubMed
PMID:8889548   PMID:12107411   PMID:12477932   PMID:28475701   PMID:29892012   PMID:32296183   PMID:32814053  


Genomics


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 6
Low 2 2 2 2 1 74 1
Below cutoff 407 444 481 274 244 226 1058 319 1293 71 431 265 48 271 649

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000619537   ⟹   ENSP00000482816
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl216,499,203 - 6,564,489 (+)Ensembl
RefSeq Acc Id: ENST00000624019   ⟹   ENSP00000485653
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl216,561,284 - 6,563,978 (+)Ensembl
RefSeq Acc Id: ENST00000624901
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl216,561,911 - 6,564,084 (+)Ensembl
RefSeq Acc Id: ENST00000624932   ⟹   ENSP00000485302
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl216,561,954 - 6,564,203 (+)Ensembl
RefSeq Acc Id: NM_001314050   ⟹   NP_001300979
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,499,203 - 6,564,489 (+)NCBI
CHM1_12144,149,991 - 44,153,755 (+)NCBI
T2T-CHM13v2.02141,498,596 - 41,563,900 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001320719   ⟹   NP_001307648
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38216,561,920 - 6,564,489 (+)NCBI
CHM1_12144,151,186 - 44,153,755 (+)NCBI
T2T-CHM13v2.02141,561,331 - 41,563,900 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001300979 (Get FASTA)   NCBI Sequence Viewer  
  NP_001307648 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH69528 (Get FASTA)   NCBI Sequence Viewer  
  AMM63584 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000291554.2
  ENSP00000381200.1
Reference Protein Sequences
RefSeq Acc Id: NP_001300979   ⟸   NM_001314050
- Peptide Label: isoform 1
- UniProtKB: E9PHE4 (UniProtKB/Swiss-Prot),   Q53X53 (UniProtKB/Swiss-Prot),   P02489 (UniProtKB/Swiss-Prot),   A0A140G945 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001307648   ⟸   NM_001320719
- Peptide Label: isoform 2
- UniProtKB: A0A8C8KJZ9 (UniProtKB/TrEMBL),   E7EWH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000485653   ⟸   ENST00000624019
RefSeq Acc Id: ENSP00000485302   ⟸   ENST00000624932
RefSeq Acc Id: ENSP00000482816   ⟸   ENST00000619537
Protein Domains
sHSP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A140G945-F1-model_v2 AlphaFold A0A140G945 1-173 view protein structure
AF-P02489-F1-model_v2 AlphaFold P02489 1-173 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:51901 AgrOrtholog
COSMIC CRYAA2 COSMIC
Ensembl Genes ENSG00000160202 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000276076 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000291554.6 UniProtKB/Swiss-Prot
  ENST00000398132.1 UniProtKB/TrEMBL
  ENST00000619537 ENTREZGENE
Gene3D-CATH 2.60.40.790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000160202 GTEx
  ENSG00000276076 GTEx
Human Proteome Map CRYAA2 Human Proteome Map
InterPro A-crystallin/Hsp20_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-crystallin/HSP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-crystallin_N UniProtKB/Swiss-Prot
  HSP20-like_chaperone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:102724652 UniProtKB/Swiss-Prot
  hsa:1409 UniProtKB/Swiss-Prot
NCBI Gene CRYAA2 ENTREZGENE
PANTHER PTHR45640 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45640:SF14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Crystallin UniProtKB/Swiss-Prot
  HSP20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Sm_HSP_B1 UniProtKB/Swiss-Prot
PRINTS ACRYSTALLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SHSP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49764 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140G945 ENTREZGENE
  A0A8C8KJZ9 ENTREZGENE, UniProtKB/TrEMBL
  CRYAA_HUMAN UniProtKB/Swiss-Prot
  E7EWH7 ENTREZGENE
  E9PHE4 ENTREZGENE
  P02489 ENTREZGENE
  Q53X53 ENTREZGENE
UniProt Secondary A0A140G945 UniProtKB/Swiss-Prot
  E9PHE4 UniProtKB/Swiss-Prot
  Q53X53 UniProtKB/Swiss-Prot