| 1312043 | Cox15 | cytochrome c oxidase assembly factor COX15 | ENCODES a protein that exhibits oxidoreductase activity, acting on the CH-CH group of donors (ortholog); INVOLVED IN cytochrome complex assembly (ortholog); heme A biosynthetic process (ortholog); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; hereditary copr oporphyria pathway; ASSOCIATED WITH cardiomyopathy (ortholog); cytochrome-c oxidase deficiency disease (ortholog); genetic disease (ortholog); FOUND IN cytochrome complex (ortholog); mitochondrion (ortholog); INTERACTS WITH 2,6-dinitrotoluene; aconitine; bisphenol A | 1 | 252554811 | 252571471 | Rat | 118 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1323821 | COX15 | cytochrome c oxidase assembly factor COX15 | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits e ncoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region. [provided by RefSeq, Jul 2008] | 10 | 99694293 | 99732127 | Human | 201 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1323822 | Cox15 | cytochrome c oxidase assembly protein 15 | Predicted to enable oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor and oxidoreductase activity, acting on the CH-CH group of donors. Predicted to be involved in cytochrome complex assembly and heme A biosynthetic process. Located in mitochondrial inner membrane. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; and mitochondrial complex IV deficiency nuclear type 6. Orthologous to human COX15 (cytochrome c oxidase assembly homolog COX15). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 43721693 | 43741439 | Mouse | 143 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9018161 | Cox15 | cytochrome c oxidase assembly factor COX15 | ENCODES a protein that exhibits oxidoreductase activity, acting on the CH-CH group of donors (ortholog); INVOLVED IN cytochrome complex assembly (ortholog); heme A biosynthetic process (ortholog); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; hereditary copr oporphyria pathway; ASSOCIATED WITH cardiomyopathy (ortholog); cytochrome-c oxidase deficiency disease (ortholog); genetic disease (ortholog); FOUND IN cytochrome complex (ortholog); mitochondrion (ortholog) | NW_004955507 | 5600605 | 5617556 | Chinchilla | 21 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11758838 | COX15 | cytochrome c oxidase assembly factor COX15 | ENCODES a protein that exhibits heme A synthase activity (inferred); metal ion binding (inferred); oxidoreductase activity (inferred); INVOLVED IN cytochrome complex assembly (inferred); heme A biosynthetic process (inferred); heme biosynthetic process (inferred); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; hereditary coproporphyria pathway; ASSOCIATED WITH cardiomyopathy (ortholog); cytochrome-c oxidase deficiency disease (ortholog); genetic disease (ortholog); FOUND IN cytochrome complex (inferred); membrane (inferred); mitochondrial inner membrane (inferred) | 10 | 96328841 | 96349655 | Bonobo | 31 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12241175 | COX15 | cytochrome c oxidase assembly homolog COX15 | ENCODES a protein that exhibits heme A synthase activity (inferred); metal ion binding (inferred); oxidoreductase activity (inferred); INVOLVED IN cytochrome complex assembly (inferred); heme A biosynthetic process (inferred); heme biosynthetic process (inferred); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; hereditary coproporphyria pathway; ASSOCIATED WITH cardiomyopathy (ortholog); cytochrome-c oxidase deficiency disease (ortholog); genetic disease (ortholog); FOUND IN cytochrome complex (inferred); membrane (inferred); mitochondrion (inferred) | 28 | 12609690 | 12625467 | Dog | 32 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12452314 | Cox15 | cytochrome c oxidase assembly factor COX15 | ENCODES a protein that exhibits heme A synthase activity (inferred); metal ion binding (inferred); oxidoreductase activity (inferred); INVOLVED IN cytochrome complex assembly (inferred); heme A biosynthetic process (inferred); heme biosynthetic process (inferred); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; hereditary coproporphyria pathway; ASSOCIATED WITH cardiomyopathy (ortholog); cytochrome-c oxidase deficiency disease (ortholog); genetic disease (ortholog); FOUND IN cytochrome complex (inferred); membrane (inferred); mitochondrial inner membrane (inferred) | NW_004936636 | 385198 | 401090 | Squirrel | 31 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14371645 | COX15 | | | | | | Yeast | | symbol | gene, null |
| 18464522 | COX15 | cytochrome c oxidase assembly factor COX15 | ENCODES a protein that exhibits heme A synthase activity (inferred); metal ion binding (inferred); oxidoreductase activity (inferred); INVOLVED IN cytochrome complex assembly (inferred); heme A biosynthetic process (inferred); heme biosynthetic process (inferred); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; hereditary coproporphyria pathway; ASSOCIATED WITH cardiomyopathy (ortholog); cytochrome-c oxidase deficiency disease (ortholog); genetic disease (ortholog); FOUND IN cytochrome complex (inferred); membrane (inferred); mitochondrial inner membrane (inferred) | | | | Green Monkey | 31 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14061065 | COX15 | cytochrome c oxidase assembly homolog COX15 | ENCODES a protein that exhibits heme A synthase activity (inferred); metal ion binding (inferred); oxidoreductase activity (inferred); INVOLVED IN cytochrome complex assembly (inferred); heme A biosynthetic process (inferred); heme biosynthetic process (inferred); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; hereditary coproporphyria pathway; ASSOCIATED WITH cardiomyopathy (ortholog); cytochrome-c oxidase deficiency disease (ortholog); genetic disease (ortholog); FOUND IN cytochrome complex (inferred); membrane (inferred); mitochondrion (inferred) | | | | Pig | 32 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18920619 | Cox15 | cytochrome c oxidase assembly factor COX15 | ENCODES a protein that exhibits heme A synthase activity (inferred); metal ion binding (inferred); oxidoreductase activity (inferred); INVOLVED IN cytochrome complex assembly (inferred); heme A biosynthetic process (inferred); heme biosynthetic process (inferred); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; hereditary coproporphyria pathway; ASSOCIATED WITH cardiomyopathy (ortholog); cytochrome-c oxidase deficiency disease (ortholog); genetic disease (ortholog); FOUND IN cytochrome complex (inferred); membrane (inferred); mitochondrial inner membrane (inferred) | | | | Naked Mole-Rat | 31 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155237885 | cox15 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626029013 | Cox15 | cytochrome c oxidase assembly factor COX15 | ENCODES a protein that exhibits oxidoreductase activity, acting on the CH-CH group of donors (ortholog); INVOLVED IN cytochrome complex assembly (ortholog); heme A biosynthetic process (ortholog); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; hereditary copr oporphyria pathway; ASSOCIATED WITH cardiomyopathy (ortholog); cytochrome-c oxidase deficiency disease (ortholog); genetic disease (ortholog); FOUND IN cytochrome complex (ortholog); mitochondrion (ortholog) | | | | Black Rat | 21 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155252104 | cox15.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155253420 | cox15.S | | | | | | African Clawed Frog | | symbol | gene, null |
