| 708454 | Cnksr2 | connector enhancer of kinase suppressor of Ras 2 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN postsynapse organization; postsynaptic specialization organization; intracellular signal transduction (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); Neurodevelopmental Disorder s (ortholog); FOUND IN extrinsic component of postsynaptic density membrane; glutamatergic synapse; neuronal cell body; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl | X | 40722843 | 40971730 | Rat | 141 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1350323 | CNKSR2 | connector enhancer of kinase suppressor of Ras 2 | This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] | X | 21374418 | 21654689 | Human | 195 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1552333 | Cnksr2 | connector enhancer of kinase suppressor of Ras 2 | Predicted to enable identical protein binding activity and protein kinase binding activity. Involved in postsynaptic specialization organization. Located in postsynaptic density. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Ho ugh type. Orthologous to human CNKSR2 (connector enhancer of kinase suppressor of Ras 2). [provided by Alliance of Genome Resources, Jul 2025] | X | 156604426 | 156827454 | Mouse | 139 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8943772 | Cnksr2 | connector enhancer of kinase suppressor of Ras 2 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN intracellular signal transduction (ortholog); postsynapse organization (ortholog); postsynaptic specialization organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); Neuro developmental Disorders (ortholog); FOUND IN extrinsic component of postsynaptic density membrane (ortholog); glutamatergic synapse (ortholog); neuronal cell body (ortholog) | NW_004955509 | 1758803 | 1977776 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11786029 | CNKSR2 | connector enhancer of kinase suppressor of Ras 2 | ENCODES a protein that exhibits protein kinase binding (inferred); INVOLVED IN intracellular signal transduction (ortholog); postsynapse organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN extrinsi c component of postsynaptic density membrane (ortholog); neuronal cell body (ortholog); postsynaptic membrane (ortholog) | X | 14004393 | 14285027 | Bonobo | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12373258 | CNKSR2 | connector enhancer of kinase suppressor of Ras 2 | ENCODES a protein that exhibits protein kinase binding (inferred); INVOLVED IN intracellular signal transduction (ortholog); postsynapse organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN extrinsi c component of postsynaptic density membrane (ortholog); neuronal cell body (ortholog); postsynaptic membrane (ortholog) | X | 17187742 | 17464526 | Dog | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12524840 | Cnksr2 | connector enhancer of kinase suppressor of Ras 2 | ENCODES a protein that exhibits protein kinase binding (inferred); INVOLVED IN intracellular signal transduction (ortholog); postsynapse organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN extrinsi c component of postsynaptic density membrane (ortholog); neuronal cell body (ortholog); postsynaptic membrane (ortholog) | NW_004936624 | 2727208 | 2989653 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155231117 | cnksr2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14225587 | CNKSR2 | connector enhancer of kinase suppressor of Ras 2 | ENCODES a protein that exhibits protein kinase binding (inferred); INVOLVED IN intracellular signal transduction (ortholog); postsynapse organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN extrinsi c component of postsynaptic density membrane (ortholog); neuronal cell body (ortholog); postsynaptic membrane (ortholog) | | | | Pig | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18922990 | Cnksr2 | connector enhancer of kinase suppressor of Ras 2 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN intracellular signal transduction (ortholog); postsynapse organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN extrinsi c component of postsynaptic density membrane (ortholog); glutamatergic synapse (ortholog); neuronal cell body (ortholog) | | | | Naked Mole-Rat | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18388338 | CNKSR2 | connector enhancer of kinase suppressor of Ras 2 | ENCODES a protein that exhibits protein kinase binding (inferred); INVOLVED IN intracellular signal transduction (ortholog); postsynapse organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN extrinsi c component of postsynaptic density membrane (ortholog); neuronal cell body (ortholog); postsynaptic membrane (ortholog) | | | | Green Monkey | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625844466 | Cnksr2 | connector enhancer of kinase suppressor of Ras 2 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN intracellular signal transduction (ortholog); postsynapse organization (ortholog); postsynaptic specialization organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); Neuro developmental Disorders (ortholog); FOUND IN extrinsic component of postsynaptic density membrane (ortholog); glutamatergic synapse (ortholog); neuronal cell body (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259071 | cnksr2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155231118 | cnksr2.S | | | | | | African Clawed Frog | | symbol | gene, null |