| 621815 | Cnga1 | cyclic nucleotide gated channel subunit alpha 1 | ENCODES a protein that exhibits cGMP binding; intracellularly cGMP-activated cation channel activity; cAMP binding (ortholog); INVOLVED IN membrane depolarization; regulation of cytosolic calcium ion concentration; spermatogenesis; PARTICIPATES IN altered visual phototransduction pathway; calcium/ca lcium-mediated signaling pathway; retinitis pigmentosa pathway; ASSOCIATED WITH retinitis pigmentosa (ortholog); retinitis pigmentosa 1 (ortholog); retinitis pigmentosa 49 (ortholog); FOUND IN intracellular cyclic nucleotide activated cation channel complex; terminal bouton; membrane (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 14 | 35920948 | 35959065 | Rat | 130 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 730948 | CNGA1 | cyclic nucleotide gated channel subunit alpha 1 | The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Multiple transcript variants have been found for this gene. [provided by RefSeq, Oct 2019] | 4 | 47935977 | 48016681 | Human | 161 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 732648 | Cnga1 | cyclic nucleotide gated channel alpha 1 | Predicted to enable cyclic nucleotide binding activity and intracellularly cyclic nucleotide-activated monoatomic cation channel activity. Predicted to be involved in membrane depolarization; monoatomic cation transport; and regulation of cytosolic calcium ion concentration. Located in photoreceptor outer segment membrane and rod photoreceptor outer segment. Is expressed in photoreceptor layer outer segment; retina; and retina outer nuclear layer. Used to study retinitis pigmentosa 49. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 49. Orthologous to human CNGA1 (cyclic nucleotide gated channel subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2025] | 5 | 72761039 | 72800095 | Mouse | 137 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8710221 | Cnga1 | cyclic nucleotide gated channel subunit alpha 1 | ENCODES a protein that exhibits cAMP binding (ortholog); cGMP binding (ortholog); intracellularly cAMP-activated cation channel activity (ortholog); INVOLVED IN membrane depolarization (ortholog); regulation of cytosolic calcium ion concentration (ortholog); spermatogenesis (ortholog); PARTICIPATES IN altered visual phototransduction pathway; calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH retinitis pigmentosa (ortholog); retinitis pigmentosa 1 (ortholog); retinitis pigmentosa 49 (ortholog); FOUND IN intracellular cyclic nucleotide activated cation channel complex (ortholog); membrane (ortholog); photoreceptor outer segment (ortholog) | NW_004955443 | 615061 | 649693 | Chinchilla | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12026989 | CNGA1 | cyclic nucleotide gated channel subunit alpha 1 | ENCODES a protein that exhibits cGMP binding (ortholog); intracellularly cGMP-activated cation channel activity (ortholog); INVOLVED IN membrane depolarization (ortholog); regulation of cytosolic calcium ion concentration (ortholog); spermatogenesis (ortholog); PARTICIPATES IN altered visual phototr ansduction pathway; calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH retinitis pigmentosa (ortholog); retinitis pigmentosa 1 (ortholog); retinitis pigmentosa 49 (ortholog); FOUND IN intracellular cyclic nucleotide activated cation channel complex (ortholog); photoreceptor outer segment (ortholog); photoreceptor outer segment membrane (ortholog) | 4 | 74196877 | 74213563 | Bonobo | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12400107 | CNGA1 | cyclic nucleotide gated channel subunit alpha 1 | ENCODES a protein that exhibits cAMP binding (ortholog); cGMP binding (ortholog); intracellularly cAMP-activated cation channel activity (ortholog); INVOLVED IN calcium ion transport (ortholog); membrane depolarization (ortholog); regulation of cytosolic calcium ion concentration (ortholog); PARTICI PATES IN altered visual phototransduction pathway; calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH retinitis pigmentosa 49; retinitis pigmentosa (ortholog); retinitis pigmentosa 1 (ortholog); FOUND IN intracellular cyclic nucleotide activated cation channel complex (ortholog); photoreceptor outer segment (ortholog); photoreceptor outer segment membrane (ortholog) | 13 | 43831159 | 43864276 | Dog | 65 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12636860 | Cnga1 | cyclic nucleotide gated channel subunit alpha 1 | ENCODES a protein that exhibits cGMP binding (ortholog); intracellularly cGMP-activated cation channel activity (ortholog); INVOLVED IN membrane depolarization (ortholog); regulation of cytosolic calcium ion concentration (ortholog); spermatogenesis (ortholog); PARTICIPATES IN altered visual phototr ansduction pathway; calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH retinitis pigmentosa (ortholog); retinitis pigmentosa 1 (ortholog); retinitis pigmentosa 49 (ortholog); FOUND IN intracellular cyclic nucleotide activated cation channel complex (ortholog); terminal bouton (ortholog) | NW_004936482 | 14091343 | 14107793 | Squirrel | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255393 | cnga1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18936710 | Cnga1 | cyclic nucleotide gated channel subunit alpha 1 | ENCODES a protein that exhibits cGMP binding (ortholog); intracellularly cGMP-activated cation channel activity (ortholog); INVOLVED IN membrane depolarization (ortholog); regulation of cytosolic calcium ion concentration (ortholog); spermatogenesis (ortholog); PARTICIPATES IN altered visual phototr ansduction pathway; calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH retinitis pigmentosa (ortholog); retinitis pigmentosa 1 (ortholog); retinitis pigmentosa 49 (ortholog); FOUND IN intracellular cyclic nucleotide activated cation channel complex (ortholog); photoreceptor outer segment (ortholog); photoreceptor outer segment membrane (ortholog) | | | | Naked Mole-Rat | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625832134 | Cnga1 | cyclic nucleotide gated channel subunit alpha 1 | ENCODES a protein that exhibits cAMP binding (ortholog); cGMP binding (ortholog); intracellularly cAMP-activated cation channel activity (ortholog); INVOLVED IN membrane depolarization (ortholog); regulation of cytosolic calcium ion concentration (ortholog); spermatogenesis (ortholog); PARTICIPATES IN altered visual phototransduction pathway; calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH retinitis pigmentosa (ortholog); retinitis pigmentosa 1 (ortholog); retinitis pigmentosa 49 (ortholog); FOUND IN intracellular cyclic nucleotide activated cation channel complex (ortholog); membrane (ortholog); photoreceptor outer segment (ortholog) | | | | Black Rat | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18346986 | CNGA1 | cyclic nucleotide gated channel subunit alpha 1 | ENCODES a protein that exhibits cGMP binding (ortholog); intracellularly cGMP-activated cation channel activity (ortholog); INVOLVED IN membrane depolarization (ortholog); regulation of cytosolic calcium ion concentration (ortholog); spermatogenesis (ortholog); PARTICIPATES IN altered visual phototr ansduction pathway; calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH retinitis pigmentosa (ortholog); retinitis pigmentosa 1 (ortholog); retinitis pigmentosa 49 (ortholog); FOUND IN intracellular cyclic nucleotide activated cation channel complex (ortholog); photoreceptor outer segment (ortholog); photoreceptor outer segment membrane (ortholog) | | | | Green Monkey | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14009413 | CNGA1 | cyclic nucleotide gated channel subunit alpha 1 | ENCODES a protein that exhibits cGMP binding (ortholog); intracellularly cGMP-activated cation channel activity (ortholog); INVOLVED IN membrane depolarization (ortholog); regulation of cytosolic calcium ion concentration (ortholog); spermatogenesis (ortholog); PARTICIPATES IN altered visual phototr ansduction pathway; calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH retinitis pigmentosa (ortholog); retinitis pigmentosa 1 (ortholog); retinitis pigmentosa 49 (ortholog); FOUND IN intracellular cyclic nucleotide activated cation channel complex (ortholog); photoreceptor outer segment (ortholog); photoreceptor outer segment membrane (ortholog) | | | | Pig | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248491 | cnga1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155257261 | cnga1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16567776 | AP005019.2 | cyclic nucleotide gated channel alpha 1 (CNGA1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |