| 1305124 | Cilp | cartilage intermediate layer protein | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog); INVOLVED IN negative regulation of gene expression (ortholog); negative regulation of insulin-like growth factor receptor signaling pathway (ortholog); negative regulation of SMAD protein signal transduction (ortholog); ASSOCIATED WITH Intervertebral Disc Disease (ortholog); osteoarthritis (ortholog); FOUND IN extracellular matrix (ortholog); extracellular space (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide | 8 | 74671696 | 74687420 | Rat | 91 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1312971 | CILP | cartilage intermediate layer protein | Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein w as thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010] | 15 | 65194760 | 65211473 | Human | 92 | symbol , COSMIC , description , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1312972 | Cilp | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | Predicted to be involved in negative regulation of gene expression and negative regulation of signal transduction. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, includin g cerebral cortex; diaphragm; lower lip; musculoskeletal system; and spleen. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human CILP (cartilage intermediate layer protein). [provided by Alliance of Genome Resources, Apr 2025] | 9 | 65172462 | 65187896 | Mouse | 91 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8961768 | Cilp | cartilage intermediate layer protein | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog); INVOLVED IN negative regulation of gene expression (ortholog); negative regulation of insulin-like growth factor receptor signaling pathway (ortholog); negative regulation of SMAD protein signal transduction (ortholog); ASSOCIATED WITH Intervertebral Disc Disease (ortholog); osteoarthritis (ortholog); FOUND IN extracellular matrix (ortholog); extracellular space (ortholog) | NW_004955450 | 10231082 | 10244632 | Chinchilla | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11713194 | CILP | cartilage intermediate layer protein | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog); INVOLVED IN negative regulation of gene expression (inferred); negative regulation of insulin-like growth factor receptor signaling pathway (inferred); negative regulation of SMAD protein signal transduction (inferred); ASSOCIATED WITH Intervertebral Disc Disease (ortholog); osteoarthritis (ortholog); FOUND IN extracellular matrix (inferred); extracellular space (inferred) | 15 | 44142312 | 44159395 | Bonobo | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12248259 | CILP | cartilage intermediate layer protein | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog); INVOLVED IN negative regulation of gene expression (inferred); negative regulation of insulin-like growth factor receptor signaling pathway (inferred); negative regulation of SMAD protein signal transduction (inferred); ASSOCIATED WITH Intervertebral Disc Disease (ortholog); osteoarthritis (ortholog); FOUND IN extracellular matrix (inferred); extracellular space (inferred) | 30 | 29573072 | 29587601 | Dog | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12580011 | Cilp | cartilage intermediate layer protein | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog); INVOLVED IN negative regulation of gene expression (inferred); negative regulation of insulin-like growth factor receptor signaling pathway (inferred); negative regulation of SMAD protein signal transduction (inferred); ASSOCIATED WITH Intervertebral Disc Disease (ortholog); osteoarthritis (ortholog); FOUND IN extracellular matrix (inferred); extracellular space (inferred) | NW_004936471 | 25501538 | 25517033 | Squirrel | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13926015 | CILP | cartilage intermediate layer protein | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog); INVOLVED IN negative regulation of gene expression (inferred); negative regulation of insulin-like growth factor receptor signaling pathway (inferred); negative regulation of SMAD protein signal transduction (inferred); ASSOCIATED WITH Intervertebral Disc Disease (ortholog); osteoarthritis (ortholog); FOUND IN extracellular matrix (inferred); extracellular space (inferred) | | | | Pig | 12 | symbol , old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 18781616 | CILP | cartilage intermediate layer protein | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog); INVOLVED IN negative regulation of gene expression (inferred); negative regulation of insulin-like growth factor receptor signaling pathway (inferred); negative regulation of SMAD protein signal transduction (inferred); ASSOCIATED WITH Intervertebral Disc Disease (ortholog); osteoarthritis (ortholog); FOUND IN extracellular matrix (inferred); extracellular space (inferred) | | | | Green Monkey | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18932640 | Cilp | cartilage intermediate layer protein | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog); INVOLVED IN negative regulation of gene expression (ortholog); negative regulation of insulin-like growth factor receptor signaling pathway (ortholog); negative regulation of SMAD protein signal transduction (ortholog); ASSOCIATED WITH Intervertebral Disc Disease (ortholog); osteoarthritis (ortholog); FOUND IN extracellular matrix (ortholog) | | | | Naked Mole-Rat | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234263 | cilp | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625860921 | Cilp | cartilage intermediate layer protein | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog); INVOLVED IN negative regulation of gene expression (ortholog); negative regulation of insulin-like growth factor receptor signaling pathway (ortholog); negative regulation of SMAD protein signal transduction (ortholog); ASSOCIATED WITH Intervertebral Disc Disease (ortholog); osteoarthritis (ortholog); FOUND IN extracellular matrix (ortholog); extracellular space (ortholog) | | | | Black Rat | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247431 | cilp.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155234264 | cilp.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12081817 | PARP16 | poly(ADP-ribose) polymerase family member 16 | ENCODES a protein that exhibits glycosyltransferase activity (inferred); kinase binding (inferred); NAD+ poly-ADP-ribosyltransferase activity (inferred); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; FOUN D IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); endoplasmic reticulum tubular network (inferred) | 30 | 29626675 | 29649992 | Dog | 32 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1322465 | CILP2 | cartilage intermediate layer protein 2 | Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025] | 19 | 19538265 | 19546659 | Human | 56 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1311157 | Cilp2 | cartilage intermediate layer protein 2 | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; furan | 16 | 19573821 | 19581100 | Rat | 56 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1615103 | Cilp2 | cartilage intermediate layer protein 2 | Predicted to enable carbohydrate binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including heart; liver; lung; musculoskeletal system; and spleen. Orthologous to human CILP >CILP2 (cartilage intermediate layer protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 70333016 | 70340042 | Mouse | 58 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8846529 | Cilp2 | cartilage intermediate layer protein 2 | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog) | NW_004955524 | 2414502 | 2421166 | Chinchilla | 2 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11817998 | CILP2 | cartilage intermediate layer protein 2 | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog); FOUND IN extracellular space (inferred) | 19 | 18976189 | 18985143 | Bonobo | 3 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12063637 | CILP2 | cartilage intermediate layer protein 2 | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog) | 20 | 43703467 | 43712576 | Dog | 3 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12635805 | Cilp2 | cartilage intermediate layer protein 2 | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog); FOUND IN extracellular space (inferred) | NW_004936596 | 1928733 | 1936606 | Squirrel | 3 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13956337 | CILP2 | cartilage intermediate layer protein 2 | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 4 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18747528 | CILP2 | cartilage intermediate layer protein 2 | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog); FOUND IN extracellular space (inferred) | | | | Green Monkey | 3 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18903939 | Cilp2 | cartilage intermediate layer protein 2 | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog); FOUND IN extracellular space (inferred) | | | | Naked Mole-Rat | 3 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241583 | cilp2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626107604 | Cilp2 | cartilage intermediate layer protein 2 | ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); dinucleotide phosphatase activity (ortholog) | | | | Black Rat | 2 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405858545 | cilp2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863286 | cilp2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863820 | cilp2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864343 | cilp2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468305 | cilp2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468524 | cilp2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626469156 | cilp2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258839 | cilp2.S | | | | | | African Clawed Frog | | symbol | gene, null |
