| 1306781 | Chmp2b | charged multivesicular body protein 2B | ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN modulation of chemical synaptic transmission; regulation of modification of postsynaptic structure; regulation of postsynapse organization; PARTICIPATES IN autophagy pathway; endocytosis pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (ortholog); Frontotemporal Lobar Degeneration (ortholog); FOUND IN glutamatergic synapse; postsynaptic density; amphisome membrane (ortholog); INTERACTS WITH 17beta-estradiol; bisphenol A; Brodifacoum | 11 | 16783971 | 16810500 | Rat | 162 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1551412 | Chmp2b | charged multivesicular body protein 2B | Predicted to enable protein domain specific binding activity. Predicted to be involved in several processes, including regulation of cell cycle process; regulation of synapse organization; and vacuolar transport. Predicted to be located in several cellular components, including bounding membrane of organelle; kinetochore microtubule; and midbody. Predicted to be part of ESCRT III complex and nuclear pore. Predicted to be active in glutamatergic synapse; multivesicular body; and postsynaptic density. Predicted to colocalize with late endosome and lysosome. Is expressed in several structures, including central nervous system; fronto-nasal process; genitourinary system; spleen; and vibrissa. Used to study frontotemporal dementia. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; frontotemporal dementia; and frontotemporal dementia and/or amyotrophic lateral sclerosis 7. Orthologous to human CHMP2B (charged multivesicular body protein 2B). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 65336014 | 65359648 | Mouse | 217 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1603668 | CHMP2B | charged multivesicular body protein 2B | This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralu menal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008] | 3 | 87227309 | 87255556 | Human | 308 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8980427 | Chmp2b | charged multivesicular body protein 2B | ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN autophagosome maturation (ortholog); autophagy (ortholog); cognition (ortholog); PARTICIPATES IN autophagy pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); frontotemporal dementia and/or amyotro phic lateral sclerosis 7 (ortholog); Frontotemporal Lobar Degeneration (ortholog); FOUND IN amphisome membrane (ortholog); autophagosome membrane (ortholog); cytoplasm (ortholog) | NW_004955407 | 6014478 | 6047916 | Chinchilla | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11732771 | CHMP2B | charged multivesicular body protein 2B | ENCODES a protein that exhibits protein domain specific binding (inferred); INVOLVED IN modulation of chemical synaptic transmission (ortholog); regulation of modification of postsynaptic structure (ortholog); regulation of postsynapse organization (ortholog); PARTICIPATES IN autophagy pathway; ASSO CIATED WITH amyotrophic lateral sclerosis (ortholog); frontotemporal dementia (ortholog); frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog) | 3 | 87358297 | 87386556 | Bonobo | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12210539 | CHMP2B | charged multivesicular body protein 2B | ENCODES a protein that exhibits protein domain specific binding (inferred); INVOLVED IN modulation of chemical synaptic transmission (ortholog); regulation of modification of postsynaptic structure (ortholog); regulation of postsynapse organization (ortholog); PARTICIPATES IN autophagy pathway; ASSO CIATED WITH amyotrophic lateral sclerosis (ortholog); frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (ortholog); Frontotemporal Lobar Degeneration (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog) | 31 | 789586 | 817925 | Dog | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12609367 | Chmp2b | charged multivesicular body protein 2B | ENCODES a protein that exhibits protein domain specific binding (inferred); INVOLVED IN modulation of chemical synaptic transmission (ortholog); regulation of modification of postsynaptic structure (ortholog); regulation of postsynapse organization (ortholog); PARTICIPATES IN autophagy pathway; ASSO CIATED WITH amyotrophic lateral sclerosis (ortholog); frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (ortholog); Frontotemporal Lobar Degeneration (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog) | NW_004936610 | 2282925 | 2320554 | Squirrel | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155230967 | chmp2b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626086323 | Chmp2b | charged multivesicular body protein 2B | ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN autophagosome maturation (ortholog); autophagy (ortholog); cognition (ortholog); PARTICIPATES IN autophagy pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); frontotemporal dementia (ortholog); fr ontotemporal dementia and/or amyotrophic lateral sclerosis 7 (ortholog); FOUND IN amphisome membrane (ortholog); autophagosome membrane (ortholog); cytoplasm (ortholog) | | | | Black Rat | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14371174 | CHMP2B | | | | | | Fly | | symbol | gene, null |
| 18906289 | Chmp2b | charged multivesicular body protein 2B | ENCODES a protein that exhibits protein domain specific binding (inferred); INVOLVED IN modulation of chemical synaptic transmission (ortholog); regulation of modification of postsynaptic structure (ortholog); regulation of postsynapse organization (ortholog); PARTICIPATES IN autophagy pathway; ASSO CIATED WITH amyotrophic lateral sclerosis (ortholog); frontotemporal dementia (ortholog); frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog) | | | | Naked Mole-Rat | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14117037 | CHMP2B | charged multivesicular body protein 2B | ENCODES a protein that exhibits protein domain specific binding (inferred); INVOLVED IN modulation of chemical synaptic transmission (ortholog); regulation of modification of postsynaptic structure (ortholog); regulation of postsynapse organization (ortholog); PARTICIPATES IN autophagy pathway; ASSO CIATED WITH amyotrophic lateral sclerosis (ortholog); frontotemporal dementia (ortholog); frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 64 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18574825 | CHMP2B | charged multivesicular body protein 2B | ENCODES a protein that exhibits protein domain specific binding (inferred); INVOLVED IN modulation of chemical synaptic transmission (ortholog); regulation of modification of postsynaptic structure (ortholog); regulation of postsynapse organization (ortholog); PARTICIPATES IN autophagy pathway; ASSO CIATED WITH amyotrophic lateral sclerosis (ortholog); frontotemporal dementia (ortholog); frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog) | | | | Green Monkey | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252582 | chmp2b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155232345 | chmp2b.S | | | | | | African Clawed Frog | | symbol | gene, null |