| 1350694 | C1QTNF1 | C1q and TNF related 1 | Enables collagen binding activity. Involved in several processes, including negative regulation of platelet aggregation; positive regulation of aldosterone secretion; and positive regulation of cytosolic calcium ion concentration. Located in extracellular space and plasma membrane. [provided by Alli ance of Genome Resources, Jul 2025] | 17 | 79022934 | 79049788 | Human | 102 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1359204 | C1qtnf1 | C1q and TNF related 1 | ENCODES a protein that exhibits collagen binding (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of platelet activation (ortholog); negative regulation of platelet aggregation (ortholog); positive regulation of aldosterone secretion (ortholog); ASSOCIATED WITH basal cell carcinoma (ortholog); FOUND IN extracellular space (ortholog); plasma membrane (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 10 | 104159021 | 104180253 | Rat | 99 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1550047 | C1qtnf1 | C1q and tumor necrosis factor related protein 1 | Enables identical protein binding activity. Acts upstream of or within positive regulation of MAPK cascade; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of glucose metabolic process. Located in extracellular space. Is expressed in axial sk eleton; cerebral cortex; heart; tooth; and vibrissa. Orthologous to human C1QTNF1 (C1q and TNF related 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 118319187 | 118342608 | Mouse | 139 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9010718 | C1qtnf1 | C1q and TNF related 1 | ENCODES a protein that exhibits collagen binding (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of platelet activation (ortholog); negative regulation of platelet aggregation (ortholog); positive regulation of aldosterone secretion (ortholog); ASSOCIATED WITH basal cell carcinoma (ortholog); FOUND IN extracellular space (ortholog); plasma membrane (ortholog) | NW_004955506 | 3680352 | 3700729 | Chinchilla | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12044177 | C1QTNF1 | C1q and TNF related 1 | ENCODES a protein that exhibits collagen binding (inferred); identical protein binding (inferred); INVOLVED IN positive regulation of MAPK cascade (ortholog); positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); regulation of glucose metabolic process (ortholog); ASSOCIATED WITH basal cell carcinoma (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred) | 17 | 73099560 | 73126304 | Bonobo | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12061507 | C1QTNF1 | C1q and TNF related 1 | ENCODES a protein that exhibits collagen binding (inferred); hydrolase activity (inferred); hydrolase activity, acting on glycosyl bonds (inferred); INVOLVED IN positive regulation of MAPK cascade (ortholog); positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ( ortholog); regulation of glucose metabolic process (ortholog); ASSOCIATED WITH basal cell carcinoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular region (inferred) | 9 | 2401369 | 2405595 | Dog | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12621570 | C1qtnf1 | C1q and TNF related 1 | ENCODES a protein that exhibits collagen binding (inferred); identical protein binding (inferred); INVOLVED IN positive regulation of MAPK cascade (ortholog); positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); regulation of glucose metabolic process (ortholog); ASSOCIATED WITH basal cell carcinoma (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred) | NW_004936594 | 3338863 | 3358137 | Squirrel | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14214287 | C1QTNF1 | C1q and TNF related 1 | ENCODES a protein that exhibits collagen binding (inferred); identical protein binding (inferred); INVOLVED IN positive regulation of MAPK cascade (ortholog); positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); regulation of glucose metabolic process (ortholog); ASSOCIATED WITH basal cell carcinoma (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18772322 | C1QTNF1 | C1q and TNF related 1 | ENCODES a protein that exhibits collagen binding (inferred); identical protein binding (inferred); INVOLVED IN positive regulation of MAPK cascade (ortholog); positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); regulation of glucose metabolic process (ortholog); ASSOCIATED WITH basal cell carcinoma (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); plasma membrane (inferred) | | | | Green Monkey | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18913640 | C1qtnf1 | C1q and TNF related 1 | ENCODES a protein that exhibits collagen binding (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of platelet activation (ortholog); negative regulation of platelet aggregation (ortholog); positive regulation of aldosterone secretion (ortholog); ASSOCIATED WITH basal cell carcinoma (ortholog); FOUND IN extracellular space (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155246493 | c1qtnf1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625855420 | C1qtnf1 | C1q and TNF related 1 | ENCODES a protein that exhibits collagen binding (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of platelet activation (ortholog); negative regulation of platelet aggregation (ortholog); positive regulation of aldosterone secretion (ortholog); ASSOCIATED WITH basal cell carcinoma (ortholog); FOUND IN extracellular space (ortholog); plasma membrane (ortholog) | | | | Black Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247038 | c1qtnf1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155246492 | c1qtnf1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 7244829 | C1QTNF1-AS1 | C1QTNF1 antisense RNA 1 | INTERACTS WITH cisplatin; cyclosporin A; DDE | 17 | 79019209 | 79027655 | Human | 5 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1307059 | C1qtnf12 | C1q and TNF related 12 | ENCODES a protein that exhibits hormone activity (ortholog); INVOLVED IN negative regulation of gluconeogenesis (ortholog); negative regulation of inflammatory response (ortholog); positive regulation of D-glucose import across plasma membrane (ortholog); FOUND IN extracellular region (ortholog); ex tracellular space (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amphetamine | 5 | 171833854 | 171838229 | Rat | 67 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1316027 | C1qtnf12 | C1q and tumor necrosis factor related 12 | Enables hormone activity. Involved in regulation of D-glucose import. Acts upstream of or within several processes, including negative regulation of gluconeogenesis; positive regulation of D-glucose import; and positive regulation of cell communication. Located in extracellular space. Is expressed i n cochlea; genitourinary system; liver lobe; thyroid gland; and vibrissa. Orthologous to human C1QTNF12 (C1q and TNF related 12). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 156046769 | 156051086 | Mouse | 82 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1603827 | C1QTNF12 | C1q and TNF related 12 | Predicted to enable hormone activity. Predicted to be involved in negative regulation of gluconeogenesis; positive regulation of D-glucose import; and positive regulation of insulin receptor signaling pathway. Predicted to act upstream of or within negative regulation of inflammatory response; posit ive regulation of cell communication; and regulation of glucose metabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025] | 1 | 1242453 | 1247280 | Human | 66 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8876868 | C1qtnf12 | C1q and TNF related 12 | ENCODES a protein that exhibits hormone activity (ortholog); INVOLVED IN negative regulation of gluconeogenesis (ortholog); negative regulation of inflammatory response (ortholog); positive regulation of D-glucose import across plasma membrane (ortholog); FOUND IN extracellular region (ortholog); ex tracellular space (ortholog) | NW_004955486 | 9541466 | 9545231 | Chinchilla | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12212095 | C1QTNF12 | C1q and TNF related 12 | ENCODES a protein that exhibits hormone activity (inferred); INVOLVED IN negative regulation of gluconeogenesis (ortholog); negative regulation of inflammatory response (ortholog); positive regulation of D-glucose import across plasma membrane (ortholog); FOUND IN extracellular space (ortholog) | 5 | 56433555 | 56438419 | Dog | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12546423 | C1qtnf12 | C1q and TNF related 12 | ENCODES a protein that exhibits hormone activity (inferred); INVOLVED IN negative regulation of gluconeogenesis (ortholog); negative regulation of inflammatory response (ortholog); positive regulation of D-glucose import across plasma membrane (ortholog); FOUND IN extracellular region (inferred); ex tracellular space (inferred) | NW_004936737 | 1877428 | 1881345 | Squirrel | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14035113 | C1QTNF12 | C1q and TNF related 12 | ENCODES a protein that exhibits hormone activity (inferred); INVOLVED IN negative regulation of gluconeogenesis (ortholog); negative regulation of inflammatory response (ortholog); positive regulation of D-glucose import across plasma membrane (ortholog); FOUND IN extracellular region (inferred); ex tracellular space (inferred) | | | | Pig | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18680982 | C1QTNF12 | C1q and TNF related 12 | ENCODES a protein that exhibits hormone activity (inferred); INVOLVED IN negative regulation of gluconeogenesis (ortholog); negative regulation of inflammatory response (ortholog); positive regulation of D-glucose import across plasma membrane (ortholog); FOUND IN extracellular region (inferred); ex tracellular space (inferred) | | | | Green Monkey | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18928502 | C1qtnf12 | C1q and TNF related 12 | ENCODES a protein that exhibits hormone activity (inferred); INVOLVED IN negative regulation of gluconeogenesis (ortholog); negative regulation of inflammatory response (ortholog); positive regulation of D-glucose import across plasma membrane (ortholog); FOUND IN extracellular region (inferred); ex tracellular space (inferred) | | | | Naked Mole-Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238639 | c1qtnf12 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 329346544 | C1QTNF12 | C1q and TNF related 12 | ENCODES a protein that exhibits hormone activity (inferred); INVOLVED IN negative regulation of gluconeogenesis (ortholog); negative regulation of inflammatory response (ortholog); positive regulation of D-glucose import across plasma membrane (ortholog); FOUND IN extracellular region (inferred); ex tracellular space (inferred) | | | | Bonobo | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626086128 | C1qtnf12 | C1q and TNF related 12 | ENCODES a protein that exhibits hormone activity (ortholog); INVOLVED IN negative regulation of gluconeogenesis (ortholog); negative regulation of inflammatory response (ortholog); positive regulation of D-glucose import across plasma membrane (ortholog); FOUND IN extracellular region (ortholog); ex tracellular space (ortholog) | | | | Black Rat | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254339 | c1qtnf12.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155251740 | c1qtnf12.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1314427 | C1QL1 | complement C1q like 1 | Predicted to enable signaling receptor binding activity. Predicted to be involved in locomotory behavior. Predicted to act upstream of or within maintenance of synapse structure; motor learning; and neuron remodeling. Predicted to be located in several cellular components, including climbing fiber; extracellular region; and presynapse. Predicted to be part of collagen trimer. Predicted to be active in cerebellar climbing fiber to Purkinje cell synapse and synaptic cleft. [provided by Alliance of Genome Resources, Apr 2025] | 17 | 44959693 | 44968303 | Human | 68 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1350440 | C1QL2 | complement C1q like 2 | Predicted to enable identical protein binding activity. Predicted to be involved in neurotransmitter receptor localization to postsynaptic specialization membrane; postsynaptic density assembly; and regulation of synapse maturation. Predicted to be located in extracellular region. Predicted to be pa rt of collagen trimer. Predicted to be active in cerebellar climbing fiber to Purkinje cell synapse; hippocampal mossy fiber to CA3 synapse; and synaptic cleft. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 119156243 | 119158751 | Human | 45 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1322092 | C1QL3 | complement C1q like 3 | Predicted to enable identical protein binding activity. Predicted to be involved in neurotransmitter receptor localization to postsynaptic specialization membrane and postsynaptic density assembly. Predicted to act upstream of or within regulation of synapse organization. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. Predicted to be active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and synaptic cleft. [provided by Alliance of Genome Resources, Jul 2025] | 10 | 16513734 | 16521879 | Human | 58 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1558310 | C1ql3 | C1q-like 3 | Enables identical protein binding activity. Involved in neurotransmitter receptor localization to postsynaptic specialization membrane and postsynaptic density assembly. Acts upstream of or within regulation of synapse organization. Located in extracellular region. Is active in glutamatergic synapse ; hippocampal mossy fiber to CA3 synapse; and synaptic cleft. Is expressed in several structures, including adipose tissue; brain; cranial ganglion; genitourinary system; and hemolymphoid system. Orthologous to human C1QL3 (complement C1q like 3). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 13006591 | 13016491 | Mouse | 76 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1604955 | C1QL4 | complement C1q like 4 | Predicted to enable identical protein binding activity. Predicted to act upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of fat cell differentiation; and negative regulation of fibroblast proliferation. Predicted to be located in extracellular space. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Jul 2025] | 12 | 49332409 | 49337188 | Human | 46 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1620572 | C1ql4 | complement component 1, q subcomponent-like 4 | Enables identical protein binding activity. Acts upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of fat cell differentiation; and negative regulation of fibroblast proliferation. Located in extracellular space. Is expressed in several structures, including bra in; genitourinary system; gut; liver; and lung. Orthologous to human C1QL4 (complement C1q like 4). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 98981967 | 98988555 | Mouse | 65 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1606147 | ERFE | erythroferrone | Enables molecular sequestering activity. Involved in negative regulation of BMP signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 238158970 | 238168890 | Human | 78 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 4140314 | OTOL1 | otolin 1 | This gene encodes a secreted glycoprotein with a C-terminal complement Cq1-like globular domain that belongs to the C1q/tumor necrosis factor-related protein (CTRP) family. The encoded protein is expressed in the inner ear and forms a multimeric complex called the otoconia, together with cerebellin- 1 and otoconin-90, as part of the otoconial membrane. It contains extensive posttranslational modifications including hydroxylated prolines and glycosylated lysines. Naturally occurring mutations in this gene are associated with abnormal otoconia formation and balance deficits resulting from vestibular dysfunction. [provided by RefSeq, Jul 2017] | 3 | 161496808 | 161503942 | Human | 22 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1622977 | C1ql2 | complement component 1, q subcomponent-like 2 | Enables identical protein binding activity. Involved in neurotransmitter receptor localization to postsynaptic specialization membrane; postsynaptic density assembly; and regulation of synapse maturation. Located in extracellular region. Part of protein-containing complex. Is active in cerebellar cl imbing fiber to Purkinje cell synapse; hippocampal mossy fiber to CA3 synapse; and synaptic cleft. Is expressed in several structures, including brain; genitourinary system; gut; liver; and lung. Orthologous to human C1QL2 (complement C1q like 2). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 120268312 | 120270903 | Mouse | 56 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |