| 1320604 | AUTS2 | activator of transcription and developmental regulator AUTS2 | This gene has been implicated in neurodevelopment and as a candidate gene for numerous neurological disorders, including autism spectrum disorders, intellectual disability, and developmental delay. Mutations in this gene have also been associated with non-neurological disorders, such as acute lympho blastic leukemia, aging of the skin, early-onset androgenetic alopecia, and certain cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2014] | 7 | 69598475 | 70793506 | Human | 274 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1622851 | Auts2 | autism susceptibility candidate 2 | Predicted to enable chromatin binding activity. Involved in several processes, including generation of neurons; positive regulation of Rac protein signal transduction; and positive regulation of lamellipodium assembly. Acts upstream of or within innate vocalization behavior and righting reflex. Loca ted in growth cone and nucleus. Colocalizes with actin cytoskeleton. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study autosomal dominant intellectual developmental disorder and autosomal dominant intellectual developmental disorder 26. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 26. Orthologous to human AUTS2 (activator of transcription and developmental regulator AUTS2). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 131466171 | 132572059 | Mouse | 173 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 2323959 | Auts2 | activator of transcription and developmental regulator AUTS2 | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); axon extension (ortholog); dendrite extension (ortholog); ASSOCIATED WITH Agenesis of Corpus Callosum (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); growth cone (ortholog); nucleoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 12 | 29739138 | 30830386 | Rat | 144 | symbol , old_gene_name , PhenoGen , name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8732173 | Auts2 | activator of transcription and developmental regulator AUTS2 | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); axon extension (ortholog); dendrite extension (ortholog); ASSOCIATED WITH Agenesis of Corpus Callosum (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); growth cone (ortholog); nucleus (ortholog) | NW_004955456 | 10294525 | 11417761 | Chinchilla | 41 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11805715 | AUTS2 | activator of transcription and developmental regulator AUTS2 | ENCODES a protein that exhibits chromatin binding (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); axon extension (ortholog); dendrite extension (ortholog); ASSOCIATED WITH Agenesis of Corpus Callosum (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); growth cone (ortholog); nucleus (ortholog) | 7 | 64822964 | 66015831 | Bonobo | 42 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12181268 | AUTS2 | activator of transcription and developmental regulator AUTS2 | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); axon extension (ortholog); dendrite extension (ortholog); ASSOCIATED WITH Agenesis of Corpus Callosum (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); growth cone (ortholog); nucleus (ortholog) | 6 | 2747288 | 3875774 | Dog | 41 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12467013 | Auts2 | activator of transcription and developmental regulator AUTS2 | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); axon extension (ortholog); dendrite extension (ortholog); ASSOCIATED WITH Agenesis of Corpus Callosum (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); growth cone (ortholog); nucleus (ortholog) | NW_004936543 | 5146961 | 6187634 | Squirrel | 41 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13842914 | AUTS2 | activator of transcription and developmental regulator AUTS2 | ENCODES a protein that exhibits chromatin binding (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); axon extension (ortholog); dendrite extension (ortholog); ASSOCIATED WITH Agenesis of Corpus Callosum (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); growth cone (ortholog); nucleus (ortholog); INTERACTS WITH zearalenone | | | | Pig | 43 | symbol , old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155257748 | auts2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625997278 | Auts2 | activator of transcription and developmental regulator AUTS2 | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); axon extension (ortholog); dendrite extension (ortholog); ASSOCIATED WITH Agenesis of Corpus Callosum (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); growth cone (ortholog); nucleus (ortholog) | | | | Black Rat | 41 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 18931055 | Auts2 | activator of transcription and developmental regulator AUTS2 | ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); axon extension (ortholog); dendrite extension (ortholog); ASSOCIATED WITH Agenesis of Corpus Callosum (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); growth cone (ortholog); nucleus (ortholog) | | | | Naked Mole-Rat | 41 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18703143 | AUTS2 | activator of transcription and developmental regulator AUTS2 | ENCODES a protein that exhibits chromatin binding (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); axon extension (ortholog); dendrite extension (ortholog); ASSOCIATED WITH Agenesis of Corpus Callosum (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder (ortholog); FOUND IN actin cytoskeleton (ortholog); growth cone (ortholog); nucleus (ortholog) | | | | Green Monkey | 42 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 405863054 | auts2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857866 | auts2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862359 | auts2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858237 | auts2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626181102 | auts2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626174061 | auts2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2314338 | Auts2Tn(sb-T2/Bart3)2.344Mcwi | autism susceptibility candidate 2; transposon insertion 2.344, Medical College of Wisconsin | This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 14th intron of the Auts2 gene. | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 1617951 | Fbrsl1 | fibrosin-like 1 | Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and testis. Orthologous to human FBRSL1 (fibrosin like 1). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 110509617 | 110596369 | Mouse | 86 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 2303695 | FBRSL1 | fibrosin like 1 | Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025] | 12 | 132490151 | 132585188 | Human | 71 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |