| 735119 | Atp6v1d | ATPase H+ transporting V1 subunit D | ENCODES a protein that exhibits proton transmembrane transporter activity (ortholog); INVOLVED IN cilium assembly (ortholog); protein localization to cilium (ortholog); synaptic vesicle lumen acidification (ortholog); PARTICIPATES IN oxidative phosphorylation pathway; phagocytosis pathway; rheumatoi d arthritis pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN extrinsic component of synaptic vesicle membrane; centrosome (ortholog); cilium (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 1-nitropropane; 2,4-diaminotoluene | 6 | 103389778 | 103405346 | Rat | 157 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1348353 | ATP6V1D | ATPase H+ transporting V1 subunit D | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated en docytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008] | 14 | 67337872 | 67359804 | Human | 172 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1553446 | Atp6v1d | ATPase, H+ transporting, lysosomal V1 subunit D | Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in synaptic vesicle lumen acidification. Part of proton-transporting V-type ATPase complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumen tal system; and sensory organ. Orthologous to human ATP6V1D (ATPase H+ transporting V1 subunit D). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 78889756 | 78908810 | Mouse | 182 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8753593 | Atp6v1d | ATPase H+ transporting V1 subunit D | ENCODES a protein that exhibits proton transmembrane transporter activity (ortholog); INVOLVED IN cilium assembly (ortholog); protein localization to cilium (ortholog); synaptic vesicle lumen acidification (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Li ver Cirrhosis (ortholog); FOUND IN centrosome (ortholog); cilium (ortholog); extrinsic component of synaptic vesicle membrane (ortholog) | NW_004955466 | 2855597 | 2869319 | Chinchilla | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11921347 | ATP6V1D | ATPase H+ transporting V1 subunit D | ENCODES a protein that exhibits proton transmembrane transporter activity (ortholog); INVOLVED IN cilium assembly (ortholog); protein localization to cilium (ortholog); synaptic vesicle lumen acidification (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Li ver Cirrhosis (ortholog); FOUND IN centrosome (ortholog); cilium (ortholog); extrinsic component of synaptic vesicle membrane (ortholog) | 14 | 47913254 | 47935376 | Bonobo | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12330009 | ATP6V1D | ATPase H+ transporting V1 subunit D | ENCODES a protein that exhibits proton transmembrane transporter activity (inferred); proton-transporting ATPase activity, rotational mechanism (inferred); INVOLVED IN cilium assembly (inferred); monoatomic ion transport (inferred); protein localization to cilium (inferred); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN extrinsic component of synaptic vesicle membrane (ortholog) | 8 | 41332581 | 41354058 | Dog | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155784613 | ATP6V1D | ATPase H+ transporting V1 subunit D | | | | | Squirrel | | symbol | gene, protein-coding |
| 155248900 | atp6v1d | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18909831 | Atp6v1d | ATPase H+ transporting V1 subunit D | ENCODES a protein that exhibits proton transmembrane transporter activity (inferred); proton-transporting ATPase activity, rotational mechanism (inferred); INVOLVED IN cell projection organization (inferred); cilium assembly (inferred); monoatomic ion transport (inferred); ASSOCIATED WITH Chemical a nd Drug Induced Liver Injury (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN extrinsic component of synaptic vesicle membrane (ortholog) | | | | Naked Mole-Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625845445 | Atp6v1d | ATPase H+ transporting V1 subunit D | ENCODES a protein that exhibits proton transmembrane transporter activity (ortholog); INVOLVED IN cilium assembly (ortholog); protein localization to cilium (ortholog); synaptic vesicle lumen acidification (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Li ver Cirrhosis (ortholog); FOUND IN centrosome (ortholog); cilium (ortholog); extrinsic component of synaptic vesicle membrane (ortholog) | | | | Black Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18679291 | ATP6V1D | ATPase H+ transporting V1 subunit D | ENCODES a protein that exhibits proton transmembrane transporter activity (ortholog); INVOLVED IN cilium assembly (ortholog); protein localization to cilium (ortholog); synaptic vesicle lumen acidification (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Li ver Cirrhosis (ortholog); FOUND IN centrosome (ortholog); cilium (ortholog); extrinsic component of synaptic vesicle membrane (ortholog) | | | | Green Monkey | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 124734307 | Atp6v1d | ATPase H+ transporting V1 subunit D | ENCODES a protein that exhibits proton-transporting ATPase activity, rotational mechanism (inferred); INVOLVED IN cilium assembly (inferred); monoatomic ion transport (inferred); protein localization to cilium (inferred); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimenta l Liver Cirrhosis (ortholog); FOUND IN centrosome (inferred); cilium (inferred); clathrin-coated vesicle membrane (inferred) | | | | Squirrel | 16 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14110622 | ATP6V1D | ATPase H+ transporting V1 subunit D | ENCODES a protein that exhibits proton transmembrane transporter activity (inferred); proton-transporting ATPase activity, rotational mechanism (inferred); INVOLVED IN cilium assembly (inferred); monoatomic ion transport (inferred); protein localization to cilium (inferred); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN extrinsic component of synaptic vesicle membrane (ortholog) | | | | Pig | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258883 | atp6v1d.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155234088 | atp6v1d.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12566886 | LOC101968194 | V-type proton ATPase subunit D | ENCODES a protein that exhibits proton transmembrane transporter activity (ortholog); INVOLVED IN synaptic vesicle lumen acidification (ortholog); FOUND IN extrinsic component of synaptic vesicle membrane (ortholog); proton-transporting V-type ATPase complex (ortholog) | NW_004936478 | 8991091 | 9065865 | Squirrel | 4 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |