| 620423 | Atp6ap1 | ATPase H+ transporting accessory protein 1 | ENCODES a protein that exhibits molecular function activator activity (ortholog); small GTPase binding (ortholog); INVOLVED IN cellular response to increased oxygen levels (ortholog); endosome to plasma membrane protein transport (ortholog); intracellular iron ion homeostasis (ortholog); PARTICIPATE S IN oxidative phosphorylation pathway; phagocytosis pathway; rheumatoid arthritis pathway; ASSOCIATED WITH congenital disorder of glycosylation Ii (ortholog); congenital disorder of glycosylation type II (ortholog); follicular lymphoma (ortholog); FOUND IN synaptic vesicle membrane; endosome membrane (ortholog); membrane (ortholog); INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione | X | 157231243 | 157238323 | Rat | 135 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733467 | ATP6AP1 | ATPase H+ transporting accessory protein 1 | This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013] | X | 154428677 | 154436516 | Human | 198 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1550133 | Atp6ap1 | ATPase, H+ transporting, lysosomal accessory protein 1 | Enables ATPase activator activity; small GTPase binding activity; and transporter activator activity. Involved in endosome to plasma membrane protein transport; osteoclast development; and synaptic vesicle lumen acidification. Is active in endosome membrane. Is expressed in integumental system; nerv ous system; sensory organ; and tail. Human ortholog(s) of this gene implicated in immunodeficiency 47. Orthologous to human ATP6AP1 (ATPase H+ transporting accessory protein 1). [provided by Alliance of Genome Resources, Jul 2025] | X | 73340753 | 73348297 | Mouse | 131 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9004375 | Atp6ap1 | ATPase H+ transporting accessory protein 1 | ENCODES a protein that exhibits molecular function activator activity (ortholog); small GTPase binding (ortholog); INVOLVED IN cellular response to increased oxygen levels (ortholog); endosome to plasma membrane protein transport (ortholog); intracellular iron ion homeostasis (ortholog); ASSOCIATED WITH congenital disorder of glycosylation Ii (ortholog); congenital disorder of glycosylation type II (ortholog); follicular lymphoma (ortholog); FOUND IN endosome membrane (ortholog); membrane (ortholog); synaptic vesicle membrane (ortholog) | NW_004955580 | 927546 | 934633 | Chinchilla | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11772958 | ATP6AP1 | ATPase H+ transporting accessory protein 1 | ENCODES a protein that exhibits ATPase activator activity (inferred); molecular function activator activity (inferred); small GTPase binding (inferred); INVOLVED IN proton-transporting V-type ATPase complex assembly (ortholog); ASSOCIATED WITH congenital disorder of glycosylation Ii (ortholog); cong enital disorder of glycosylation type II (ortholog); follicular lymphoma (ortholog); FOUND IN synaptic vesicle membrane (ortholog) | X | 143870421 | 143878288 | Bonobo | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12121286 | ATP6AP1 | ATPase H+ transporting accessory protein 1 | ENCODES a protein that exhibits molecular function activator activity (inferred); small GTPase binding (inferred); INVOLVED IN proton-transporting V-type ATPase complex assembly (ortholog); ASSOCIATED WITH congenital disorder of glycosylation Ii (ortholog); congenital disorder of glycosylation type II (ortholog); follicular lymphoma (ortholog); FOUND IN synaptic vesicle membrane (ortholog) | X | 122133314 | 122140949 | Dog | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12479623 | Atp6ap1 | ATPase H+ transporting accessory protein 1 | ENCODES a protein that exhibits ATPase activator activity (inferred); molecular function activator activity (inferred); small GTPase binding (inferred); INVOLVED IN proton-transporting V-type ATPase complex assembly (ortholog); ASSOCIATED WITH congenital disorder of glycosylation Ii (ortholog); cong enital disorder of glycosylation type II (ortholog); follicular lymphoma (ortholog); FOUND IN synaptic vesicle membrane (ortholog) | NW_004936809 | 1179507 | 1188172 | Squirrel | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14235335 | ATP6AP1 | ATPase H+ transporting accessory protein 1 | ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN endosome to plasma membrane protein transport (ortholog); osteoclast development (ortholog); proton-transporting V-type ATPase complex assembly (ortholog); ASSOCIATED WITH congenital disorder of glycosylation Ii (ortholog); congenital disorder of glycosylation type II (ortholog); follicular lymphoma (ortholog); FOUND IN synaptic vesicle membrane (ortholog) | | | | Pig | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18458260 | ATP6AP1 | ATPase H+ transporting accessory protein 1 | ENCODES a protein that exhibits ATPase activator activity (inferred); molecular function activator activity (inferred); small GTPase binding (inferred); INVOLVED IN proton-transporting V-type ATPase complex assembly (ortholog); ASSOCIATED WITH congenital disorder of glycosylation Ii (ortholog); cong enital disorder of glycosylation type II (ortholog); follicular lymphoma (ortholog); FOUND IN synaptic vesicle membrane (ortholog) | | | | Green Monkey | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18926017 | Atp6ap1 | ATPase H+ transporting accessory protein 1 | ENCODES a protein that exhibits molecular function activator activity (ortholog); small GTPase binding (ortholog); INVOLVED IN cellular response to increased oxygen levels (ortholog); endosome to plasma membrane protein transport (ortholog); intracellular iron ion homeostasis (ortholog); ASSOCIATED WITH congenital disorder of glycosylation Ii (ortholog); congenital disorder of glycosylation type II (ortholog); follicular lymphoma (ortholog); FOUND IN endosome membrane (ortholog); membrane (ortholog); synaptic vesicle membrane (ortholog) | | | | Naked Mole-Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 596933655 | atp6ap1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596934428 | atp6ap1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596934888 | atp6ap1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596936004 | atp6ap1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626128535 | Atp6ap1 | ATPase H+ transporting accessory protein 1 | ENCODES a protein that exhibits molecular function activator activity (ortholog); small GTPase binding (ortholog); INVOLVED IN cellular response to increased oxygen levels (ortholog); endosome to plasma membrane protein transport (ortholog); intracellular iron ion homeostasis (ortholog); ASSOCIATED WITH congenital disorder of glycosylation Ii (ortholog); congenital disorder of glycosylation type II (ortholog); follicular lymphoma (ortholog); FOUND IN endosome membrane (ortholog); membrane (ortholog); synaptic vesicle membrane (ortholog) | | | | Black Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 287401440 | atp6ap1.1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155233707 | atp6ap1.2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 16550948 | ATP6AP1-DT | ATP6AP1 divergent transcript | INTERACTS WITH 17beta-estradiol; aristolochic acid A; benzo[a]pyrene | X | 154424380 | 154428479 | Human | 3 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 287401262 | atp6ap1.1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 329329190 | atp6ap1.1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155232556 | atp6ap1.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155238018 | atp6ap1.2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1564936 | Atp6ap1l | ATPase H+ transporting accessory protein 1 like | ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN membrane (inferred); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; aflatoxin B1 | 2 | 23772724 | 23814913 | Rat | 59 | symbol , PhenoGen | gene, protein-coding, INFERRED [RefSeq] |
| 1603596 | ATP6AP1L | ATPase H+ transporting accessory protein 1 like (pseudogene) | Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 82278650 | 82318806 | Human | 60 | symbol , COSMIC , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 1614699 | Atp6ap1l | ATPase, H+ transporting, lysosomal accessory protein 1-like | Predicted to enable ATPase activator activity. Predicted to be involved in regulation of cellular pH. Predicted to be part of proton-transporting V-type ATPase complex. Orthologous to human ATP6AP1L (ATPase H+ transporting accessory protein 1 like (pseudogene)). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 91031558 | 91053478 | Mouse | 67 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9056945 | Atp6ap1l | ATPase H+ transporting accessory protein 1 like | ASSOCIATED WITH Breast Neoplasms (ortholog) | NW_004955418 | 28077388 | 28106183 | Chinchilla | 1 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12205430 | ATP6AP1L | ATPase H+ transporting accessory protein 1 like | ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN bounding membrane of organelle (inferred); cytoplasmic vesicle membrane (inferred); endomembrane system (inferred) | 3 | 25168116 | 25191547 | Dog | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12523033 | Atp6ap1l | ATPase H+ transporting accessory protein 1 like | ENCODES a protein that exhibits ATPase activator activity (inferred); INVOLVED IN proton transmembrane transport (inferred); regulation of cellular pH (inferred); ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN bounding membrane of organelle (inferred); clathrin-coated vesicle membrane (inferr ed); cytoplasmic vesicle membrane (inferred) | NW_004936469 | 1539985 | 1562286 | Squirrel | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13987126 | ATP6AP1L | ATPase H+ transporting accessory protein 1 like | ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN bounding membrane of organelle (inferred); cytoplasmic vesicle membrane (inferred); endomembrane system (inferred) | | | | Pig | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18911943 | Atp6ap1l | ATPase H+ transporting accessory protein 1 like | ENCODES a protein that exhibits ATPase activator activity (inferred); INVOLVED IN proton transmembrane transport (inferred); regulation of cellular pH (inferred); ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN bounding membrane of organelle (inferred); clathrin-coated vesicle membrane (inferr ed); cytoplasmic vesicle membrane (inferred) | | | | Naked Mole-Rat | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288057343 | atp6ap1l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625918510 | Atp6ap1l | ATPase H+ transporting accessory protein 1 like | ASSOCIATED WITH Breast Neoplasms (ortholog) | | | | Black Rat | 1 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288057342 | atp6ap1l.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 11843537 | LOC100995668 | V-type proton ATPase subunit S1-like protein | ENCODES a protein that exhibits ATPase activator activity (inferred); INVOLVED IN regulation of cellular pH (inferred); ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN bounding membrane of organelle (inferred); cytoplasmic vesicle membrane (inferred); endomembrane system (inferred) | 5 | 32964011 | 33004822 | Bonobo | 8 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18748755 | LOC103224026 | V-type proton ATPase subunit S1-like protein | ENCODES a protein that exhibits ATPase activator activity (inferred); INVOLVED IN regulation of cellular pH (inferred); ASSOCIATED WITH Breast Neoplasms (ortholog); FOUND IN bounding membrane of organelle (inferred); cytoplasmic vesicle membrane (inferred); endomembrane system (inferred) | | | | Green Monkey | 8 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |