| 1305111 | Arhgef12 | Rho guanine nucleotide exchange factor 12 | ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); regulation of blood pressure (ortholog); Rho-activating G protein-coupled receptor signaling path way (ortholog); PARTICIPATES IN tuberculosis pathway; ASSOCIATED WITH glaucoma (ortholog); Weight Gain (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil | 8 | 52247047 | 52373158 | Rat | 120 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1312950 | ARHGEF12 | Rho guanine nucleotide exchange factor 12 | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lym phoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] | 11 | 120336413 | 120489937 | Human | 128 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1312951 | Arhgef12 | Rho guanine nucleotide exchange factor 12 | Predicted to enable G protein-coupled receptor binding activity and guanyl-nucleotide exchange factor activity. Involved in regulation of blood pressure. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitou rinary system; nervous system; respiratory system; and skin. Orthologous to human ARHGEF12 (Rho guanine nucleotide exchange factor 12). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 42875138 | 43017069 | Mouse | 138 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8736453 | Arhgef12 | Rho guanine nucleotide exchange factor 12 | ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); regulation of blood pressure (ortholog); Rho-activating G protein-coupled receptor signaling path way (ortholog); ASSOCIATED WITH glaucoma (ortholog); Weight Gain (ortholog); FOUND IN cytoplasm (ortholog) | NW_004955412 | 21344671 | 21497951 | Chinchilla | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11672498 | ARHGEF12 | Rho guanine nucleotide exchange factor 12 | ENCODES a protein that exhibits G protein-coupled receptor binding (inferred); GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); regulation of blood pressure (ortholog); ASSOCIATED WITH gl aucoma (ortholog); Weight Gain (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred) | 11 | 115173575 | 115327040 | Bonobo | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12280373 | ARHGEF12 | Rho guanine nucleotide exchange factor 12 | ENCODES a protein that exhibits G protein-coupled receptor binding (inferred); GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); regulation of blood pressure (ortholog); ASSOCIATED WITH gl aucoma (ortholog); Weight Gain (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred) | 5 | 13519094 | 13669154 | Dog | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12660811 | Arhgef12 | Rho guanine nucleotide exchange factor 12 | ENCODES a protein that exhibits G protein-coupled receptor binding (inferred); GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); regulation of blood pressure (ortholog); ASSOCIATED WITH gl aucoma (ortholog); Weight Gain (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred) | NW_004936542 | 5197100 | 5335338 | Squirrel | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902677 | Arhgef12 | Rho guanine nucleotide exchange factor 12 | ENCODES a protein that exhibits G protein-coupled receptor binding (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); regulation of blood pressure (ortholog); Rho-activating G protein-coupled receptor signaling path way (ortholog); ASSOCIATED WITH glaucoma (ortholog); Weight Gain (ortholog); FOUND IN cytoplasm (inferred) | | | | Naked Mole-Rat | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243487 | arhgef12 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18417981 | ARHGEF12 | Rho guanine nucleotide exchange factor 12 | ENCODES a protein that exhibits G protein-coupled receptor binding (inferred); GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); regulation of blood pressure (ortholog); ASSOCIATED WITH gl aucoma (ortholog); Weight Gain (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14263211 | ARHGEF12 | Rho guanine nucleotide exchange factor 12 | ENCODES a protein that exhibits G protein-coupled receptor binding (inferred); GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); regulation of blood pressure (ortholog); ASSOCIATED WITH gl aucoma (ortholog); Weight Gain (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred) | | | | Pig | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625848589 | Arhgef12 | Rho guanine nucleotide exchange factor 12 | ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (ortholog); regulation of blood pressure (ortholog); Rho-activating G protein-coupled receptor signaling path way (ortholog); ASSOCIATED WITH glaucoma (ortholog); Weight Gain (ortholog); FOUND IN cytoplasm (ortholog) | | | | Black Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254691 | arhgef12.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243488 | arhgef12.S | | | | | | African Clawed Frog | | symbol | gene, null |