| 1342475 | APBB2 | amyloid beta precursor protein binding family B member 2 | The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] | 4 | 40810027 | 41214542 | Human | 156 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1558141 | Apbb2 | amyloid beta precursor protein binding family B member 2 | Predicted to enable amyloid-beta binding activity and molecular adaptor activity. Involved in maintenance of lens transparency and smooth muscle contraction. Acts upstream of or within extracellular matrix organization; generation of neurons; and regulation of apoptotic process. Located in cytoplasm . Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in Alzheimer's disease and cognitive disorder. Orthologous to human APBB2 (amyloid beta precursor protein binding family B member 2). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 66456068 | 66779189 | Mouse | 179 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1562438 | Apbb2 | amyloid beta precursor protein binding family B member 2 | ENCODES a protein that exhibits amyloid-beta binding (inferred); INVOLVED IN axon guidance (ortholog); extracellular matrix organization (ortholog); maintenance of lens transparency (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); cognitive disorder (ortholog); Weight Gain (ortholog); FOU ND IN cytoplasm (ortholog); early endosome (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 14 | 41849638 | 42232930 | Rat | 155 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 9003015 | Apbb2 | amyloid beta precursor protein binding family B member 2 | INVOLVED IN axon guidance (ortholog); extracellular matrix organization (ortholog); maintenance of lens transparency (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); cognitive disorder (ortholog); Weight Gain (ortholog); FOUND IN cytoplasm (ortholog); early endosome (ortholog); endoplasmi c reticulum (ortholog) | NW_004955443 | 6513762 | 6786247 | Chinchilla | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11726202 | APBB2 | amyloid beta precursor protein binding family B member 2 | ENCODES a protein that exhibits amyloid-beta binding (inferred); INVOLVED IN axon guidance (ortholog); extracellular matrix organization (ortholog); negative regulation of apoptotic process (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); cognitive disorder (ortholog); Weight Gain (orthol og); FOUND IN cytoplasm (inferred); early endosome (inferred); endoplasmic reticulum (inferred) | 4 | 35133490 | 35538443 | Bonobo | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12333919 | APBB2 | amyloid beta precursor protein binding family B member 2 | ENCODES a protein that exhibits amyloid-beta binding (inferred); INVOLVED IN axon guidance (ortholog); extracellular matrix organization (ortholog); negative regulation of apoptotic process (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); cognitive disorder (ortholog); Weight Gain (orthol og); FOUND IN cytoplasm (inferred); early endosome (inferred); endoplasmic reticulum (inferred); INTERACTS WITH bisphenol A | 3 | 71454814 | 71830482 | Dog | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12570823 | Apbb2 | amyloid beta precursor protein binding family B member 2 | ENCODES a protein that exhibits amyloid-beta binding (inferred); INVOLVED IN axon guidance (ortholog); extracellular matrix organization (ortholog); maintenance of lens transparency (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); cognitive disorder (ortholog); Weight Gain (ortholog); FOU ND IN early endosome (ortholog); endoplasmic reticulum (ortholog); Golgi apparatus (ortholog) | NW_004936482 | 8166380 | 8489489 | Squirrel | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18929626 | Apbb2 | amyloid beta precursor protein binding family B member 2 | ENCODES a protein that exhibits amyloid-beta binding (inferred); INVOLVED IN axon guidance (ortholog); extracellular matrix organization (ortholog); maintenance of lens transparency (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); cognitive disorder (ortholog); Weight Gain (ortholog); FOU ND IN early endosome (ortholog); endoplasmic reticulum (ortholog); Golgi apparatus (ortholog) | | | | Naked Mole-Rat | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14084363 | APBB2 | amyloid beta precursor protein binding family B member 2 | ENCODES a protein that exhibits amyloid-beta binding (inferred); INVOLVED IN axon guidance (ortholog); extracellular matrix organization (ortholog); negative regulation of apoptotic process (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); cognitive disorder (ortholog); Weight Gain (orthol og); FOUND IN cytoplasm (inferred); early endosome (inferred); endoplasmic reticulum (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238576 | apbb2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625916004 | Apbb2 | amyloid beta precursor protein binding family B member 2 | INVOLVED IN axon guidance (ortholog); extracellular matrix organization (ortholog); maintenance of lens transparency (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); cognitive disorder (ortholog); Weight Gain (ortholog); FOUND IN cytoplasm (ortholog); early endosome (ortholog); endoplasmi c reticulum (ortholog) | | | | Black Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18578140 | APBB2 | amyloid beta precursor protein binding family B member 2 | ENCODES a protein that exhibits amyloid-beta binding (inferred); INVOLVED IN axon guidance (ortholog); extracellular matrix organization (ortholog); negative regulation of apoptotic process (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); cognitive disorder (ortholog); Weight Gain (orthol og); FOUND IN cytoplasm (inferred); early endosome (inferred); endoplasmic reticulum (inferred) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238577 | apbb2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259887 | apbb2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359277 | APBB2-AS1 | APBB2 antisense RNA 1 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |