Apbb2 (amyloid beta precursor protein binding family B member 2) - Rat Genome Database

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Gene: Apbb2 (amyloid beta precursor protein binding family B member 2) Rattus norvegicus
Analyze
Symbol: Apbb2
Name: amyloid beta precursor protein binding family B member 2
RGD ID: 1562438
Description: Predicted to enable amyloid-beta binding activity. Predicted to be involved in several processes, including maintenance of lens transparency; negative regulation of cell cycle phase transition; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within extracellular matrix organization; generation of neurons; and regulation of apoptotic process. Predicted to be located in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in Alzheimer's disease and cognitive disorder. Orthologous to human APBB2 (amyloid beta precursor protein binding family B member 2); INTERACTS WITH 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: amyloid beta (A4) precursor protein-binding, family B, member 2; amyloid beta A4 precursor protein-binding family B member 2; amyloid-beta A4 precursor protein-binding family B member 2; LOC305338; RGD1562438; similar to amyloid beta (A4) precursor protein-binding, family B, member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21441,557,918 - 41,878,622 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1441,557,972 - 41,877,495 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01443,205,047 - 43,526,968 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1443,512,901 - 43,523,080 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01443,126,873 - 43,315,801 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41444,197,568 - 44,526,047 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1440,786,859 - 41,031,083 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
chloroprene  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dieldrin  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
fulvestrant  (ISO)
geraniol  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
nickel dichloride  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
picoxystrobin  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
resorcinol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. APBB2 genetic polymorphisms are associated with severe cognitive impairment in centenarians. Golanska E, etal., Exp Gerontol. 2013 Apr;48(4):391-4. doi: 10.1016/j.exger.2013.01.013. Epub 2013 Feb 4.
3. Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. Li Y, etal., Hum Mutat. 2005 Mar;25(3):270-7.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12089154   PMID:15629131   PMID:16407979  


Genomics

Comparative Map Data
Apbb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21441,557,918 - 41,878,622 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1441,557,972 - 41,877,495 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01443,205,047 - 43,526,968 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1443,512,901 - 43,523,080 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01443,126,873 - 43,315,801 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41444,197,568 - 44,526,047 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1440,786,859 - 41,031,083 (+)NCBICelera
Cytogenetic Map14p11NCBI
APBB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38440,810,027 - 41,214,542 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl440,810,027 - 41,216,714 (-)EnsemblGRCh38hg38GRCh38
GRCh37440,812,044 - 41,216,559 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36440,510,996 - 40,911,245 (-)NCBINCBI36Build 36hg18NCBI36
Build 34440,657,166 - 41,057,416NCBI
Celera441,255,358 - 41,659,952 (-)NCBICelera
Cytogenetic Map4p14-p13NCBI
HuRef440,134,003 - 40,538,593 (-)NCBIHuRef
CHM1_1440,811,768 - 41,216,779 (-)NCBICHM1_1
T2T-CHM13v2.0440,783,978 - 41,188,337 (-)NCBIT2T-CHM13v2.0
Apbb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39566,456,068 - 66,779,189 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl566,456,046 - 66,776,127 (-)EnsemblGRCm39 Ensembl
GRCm38566,298,725 - 66,619,064 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl566,298,703 - 66,618,784 (-)EnsemblGRCm38mm10GRCm38
MGSCv37566,693,127 - 67,009,910 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36566,581,023 - 66,897,806 (-)NCBIMGSCv36mm8
Celera563,600,514 - 63,917,425 (-)NCBICelera
Cytogenetic Map5C3.1NCBI
Apbb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554436,513,980 - 6,783,014 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554436,513,762 - 6,786,247 (+)NCBIChiLan1.0ChiLan1.0
APBB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1441,186,549 - 41,591,159 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0435,133,490 - 35,538,443 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1440,984,632 - 41,386,264 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl440,988,428 - 41,189,064 (-)Ensemblpanpan1.1panPan2
APBB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,454,814 - 71,830,482 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,454,585 - 71,826,749 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha374,004,793 - 74,379,285 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0372,215,300 - 72,590,507 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl372,215,204 - 72,588,489 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1371,492,277 - 71,866,478 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,647,497 - 72,022,440 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0372,031,249 - 72,406,523 (+)NCBIUU_Cfam_GSD_1.0
Apbb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528537,746,664 - 38,134,814 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364828,166,380 - 8,489,489 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APBB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl831,921,593 - 32,193,940 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1831,921,587 - 32,302,237 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2833,221,452 - 33,426,852 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APBB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1279,130,947 - 9,530,897 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl279,311,146 - 9,534,105 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604755,463,239 - 55,867,809 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apbb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476125,924,714 - 26,262,386 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476125,924,747 - 26,265,763 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apbb2
1668 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1736
Count of miRNA genes:306
Interacting mature miRNAs:424
Transcripts:ENSRNOT00000029018, ENSRNOT00000049214, ENSRNOT00000050664
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat

Markers in Region
D14Mit9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21441,873,444 - 41,873,686 (+)MAPPERmRatBN7.2
Rnor_6.01443,521,791 - 43,522,032NCBIRnor6.0
Rnor_5.01443,311,872 - 43,312,113UniSTSRnor5.0
RGSC_v3.41444,521,426 - 44,521,668RGDRGSC3.4
RGSC_v3.41444,521,427 - 44,521,668UniSTSRGSC3.4
RGSC_v3.11444,523,774 - 44,524,072RGD
Celera1441,025,904 - 41,026,147UniSTS
RH 2.0 Map14459.3RGD
Cytogenetic Map14p11UniSTS
D14Mgh5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21441,871,022 - 41,871,196 (+)MAPPERmRatBN7.2
Rnor_6.01443,519,364 - 43,519,537NCBIRnor6.0
Rnor_5.01443,309,667 - 43,309,840UniSTSRnor5.0
RGSC_v3.41444,519,091 - 44,519,264UniSTSRGSC3.4
RGSC_v3.41444,519,090 - 44,519,264RGDRGSC3.4
RGSC_v3.41444,508,396 - 44,508,570RGDRGSC3.4
RGSC_v3.41444,508,397 - 44,508,570UniSTSRGSC3.4
RGSC_v3.11444,521,481 - 44,521,655RGD
Celera1441,023,490 - 41,023,663UniSTS
Cytogenetic Map14p11UniSTS
D14Mgh6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21441,658,190 - 41,658,327 (+)MAPPERmRatBN7.2
Rnor_6.01443,305,859 - 43,305,995NCBIRnor6.0
Rnor_5.01443,097,692 - 43,097,828UniSTSRnor5.0
RGSC_v3.41444,291,075 - 44,291,212RGDRGSC3.4
RGSC_v3.41444,291,076 - 44,291,212UniSTSRGSC3.4
RGSC_v3.11444,293,466 - 44,293,603RGD
Celera1440,811,690 - 40,811,826UniSTS
Cytogenetic Map14p11UniSTS
D14Rat56  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21441,625,003 - 41,625,190 (+)MAPPERmRatBN7.2
Rnor_6.01443,272,603 - 43,272,789NCBIRnor6.0
Rnor_5.01443,064,714 - 43,064,900UniSTSRnor5.0
RGSC_v3.41444,257,619 - 44,257,806RGDRGSC3.4
RGSC_v3.41444,257,620 - 44,257,806UniSTSRGSC3.4
RGSC_v3.11444,260,010 - 44,260,197RGD
Celera1440,778,345 - 40,778,531UniSTS
RH 2.0 Map14439.5RGD
SHRSP x BN Map1428.2599RGD
FHH x ACI Map1439.47RGD
Cytogenetic Map14p11UniSTS
D14Rat63  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21441,806,290 - 41,806,385 (+)MAPPERmRatBN7.2
Rnor_6.01443,454,225 - 43,454,319NCBIRnor6.0
Rnor_5.01443,244,698 - 43,244,792UniSTSRnor5.0
RGSC_v3.41444,443,343 - 44,443,438RGDRGSC3.4
RGSC_v3.41444,443,344 - 44,443,438UniSTSRGSC3.4
RGSC_v3.11444,445,734 - 44,445,829RGD
Celera1440,958,541 - 40,958,635UniSTS
RH 2.0 Map14460.1RGD
SHRSP x BN Map1428.34RGD
FHH x ACI Map1439.47RGD
Cytogenetic Map14p11UniSTS
D14Got53  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21441,588,838 - 41,589,076 (+)MAPPERmRatBN7.2
Rnor_6.01443,236,538 - 43,236,775NCBIRnor6.0
Rnor_5.01443,028,642 - 43,028,879UniSTSRnor5.0
RGSC_v3.41444,220,787 - 44,221,025RGDRGSC3.4
RGSC_v3.41444,220,788 - 44,221,025UniSTSRGSC3.4
RGSC_v3.11444,223,178 - 44,223,416RGD
Celera1440,742,201 - 40,742,438UniSTS
RH 2.0 Map14449.1RGD
Cytogenetic Map14p11UniSTS
BI277850  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21441,877,776 - 41,877,949 (+)MAPPERmRatBN7.2
Rnor_6.01443,526,123 - 43,526,295NCBIRnor6.0
Rnor_5.01443,316,204 - 43,316,376UniSTSRnor5.0
RGSC_v3.41444,525,759 - 44,525,931UniSTSRGSC3.4
Celera1441,030,238 - 41,030,410UniSTS
Cytogenetic Map14p11UniSTS
RH141190  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21441,877,158 - 41,877,363 (+)MAPPERmRatBN7.2
Rnor_6.01443,525,505 - 43,525,709NCBIRnor6.0
Rnor_5.01443,315,586 - 43,315,790UniSTSRnor5.0
RGSC_v3.41444,525,141 - 44,525,345UniSTSRGSC3.4
Celera1441,029,620 - 41,029,824UniSTS
Cytogenetic Map14p11UniSTS
stSG602612  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21441,834,909 - 41,836,169 (+)MAPPERmRatBN7.2
mRatBN7.21441,834,961 - 41,836,169 (+)MAPPERmRatBN7.2
Rnor_6.01443,482,833 - 43,484,040NCBIRnor6.0
Rnor_6.01443,482,781 - 43,484,040NCBIRnor6.0
Rnor_5.01443,273,136 - 43,274,343UniSTSRnor5.0
Rnor_5.01443,273,084 - 43,274,343UniSTSRnor5.0
RGSC_v3.41444,472,344 - 44,473,603UniSTSRGSC3.4
RGSC_v3.41444,472,396 - 44,473,603UniSTSRGSC3.4
Celera1440,987,207 - 40,988,414UniSTS
Celera1440,987,155 - 40,988,414UniSTS
Cytogenetic Map14p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 24 8 19 8 8 11 74 35 35 11 8
Low 33 33 33 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_006221745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000050664   ⟹   ENSRNOP00000041399
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1443,512,901 - 43,523,080 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100119   ⟹   ENSRNOP00000082727
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1441,627,942 - 41,877,495 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106751   ⟹   ENSRNOP00000088203
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1441,627,942 - 41,877,495 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115068   ⟹   ENSRNOP00000084619
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1441,633,251 - 41,875,421 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119030   ⟹   ENSRNOP00000084452
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1441,557,972 - 41,814,078 (+)Ensembl
RefSeq Acc Id: XM_017599456   ⟹   XP_017454945
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21441,557,946 - 41,878,622 (+)NCBI
Rnor_6.01443,205,047 - 43,526,335 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599457   ⟹   XP_017454946
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21441,834,981 - 41,878,622 (+)NCBI
Rnor_6.01443,488,336 - 43,526,968 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039092524   ⟹   XP_038948452
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21441,557,946 - 41,878,622 (+)NCBI
RefSeq Acc Id: XM_039092525   ⟹   XP_038948453
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21441,557,931 - 41,877,374 (+)NCBI
RefSeq Acc Id: XM_039092526   ⟹   XP_038948454
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21441,557,941 - 41,877,374 (+)NCBI
RefSeq Acc Id: XM_039092527   ⟹   XP_038948455
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21441,557,931 - 41,877,374 (+)NCBI
RefSeq Acc Id: XM_039092528   ⟹   XP_038948456
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21441,557,931 - 41,877,374 (+)NCBI
RefSeq Acc Id: XM_039092529   ⟹   XP_038948457
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21441,557,946 - 41,878,622 (+)NCBI
RefSeq Acc Id: XM_039092530   ⟹   XP_038948458
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21441,557,931 - 41,877,374 (+)NCBI
RefSeq Acc Id: XM_039092531   ⟹   XP_038948459
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21441,557,931 - 41,877,374 (+)NCBI
RefSeq Acc Id: XM_039092532   ⟹   XP_038948460
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21441,557,928 - 41,877,374 (+)NCBI
RefSeq Acc Id: XM_039092533   ⟹   XP_038948461
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21441,557,918 - 41,825,214 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_017454945   ⟸   XM_017599456
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A9I8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454946   ⟸   XM_017599457
- Peptide Label: isoform X11
- UniProtKB: F1LZU7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000041399   ⟸   ENSRNOT00000050664
RefSeq Acc Id: XP_038948461   ⟸   XM_039092533
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038948460   ⟸   XM_039092532
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038948455   ⟸   XM_039092527
- Peptide Label: isoform X4
- UniProtKB: A0A8I6G7S6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948458   ⟸   XM_039092530
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038948453   ⟸   XM_039092525
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038948456   ⟸   XM_039092528
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038948459   ⟸   XM_039092531
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038948454   ⟸   XM_039092526
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038948452   ⟸   XM_039092524
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A9I8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948457   ⟸   XM_039092529
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZYC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000082727   ⟸   ENSRNOT00000100119
RefSeq Acc Id: ENSRNOP00000084619   ⟸   ENSRNOT00000115068
RefSeq Acc Id: ENSRNOP00000088203   ⟸   ENSRNOT00000106751
RefSeq Acc Id: ENSRNOP00000084452   ⟸   ENSRNOT00000119030
Protein Domains
PID   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LZU7-F1-model_v2 AlphaFold F1LZU7 1-210 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562438 AgrOrtholog
BioCyc Gene G2FUF-15765 BioCyc
Ensembl Genes ENSRNOG00000025509 Ensembl
  ENSRNOG00000063717 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000082727 ENTREZGENE
  ENSRNOP00000082727.1 UniProtKB/TrEMBL
  ENSRNOP00000084452 ENTREZGENE
  ENSRNOP00000084452.1 UniProtKB/TrEMBL
  ENSRNOP00000084619 ENTREZGENE
  ENSRNOP00000084619.1 UniProtKB/TrEMBL
  ENSRNOP00000088203 ENTREZGENE
  ENSRNOP00000088203.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000100119 ENTREZGENE
  ENSRNOT00000100119.1 UniProtKB/TrEMBL
  ENSRNOT00000106751 ENTREZGENE
  ENSRNOT00000106751.1 UniProtKB/TrEMBL
  ENSRNOT00000115068 ENTREZGENE
  ENSRNOT00000115068.1 UniProtKB/TrEMBL
  ENSRNOT00000119030 ENTREZGENE
  ENSRNOT00000119030.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro APBB1/2/3 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
NCBI Gene 305338 ENTREZGENE
PANTHER AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 2 UniProtKB/TrEMBL
  PTHR14058 UniProtKB/TrEMBL
Pfam PF00397 UniProtKB/TrEMBL
  PID UniProtKB/TrEMBL
PhenoGen Apbb2 PhenoGen
PROSITE PID UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART PTB UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF51045 UniProtKB/TrEMBL
UniProt A0A8I5ZYC7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZL5_RAT UniProtKB/TrEMBL
  A0A8I6A9I8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G7S6 ENTREZGENE, UniProtKB/TrEMBL
  F1LZU7 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Apbb2  amyloid beta precursor protein binding family B member 2  Apbb2  amyloid beta precursor protein binding family B member 2  Data Merged 737654 PROVISIONAL
2021-08-09 Apbb2  amyloid beta precursor protein binding family B member 2      Symbol and Name status set to provisional 45752 PROVISIONAL
2016-01-27 Apbb2  amyloid beta precursor protein binding family B member 2  Apbb2  amyloid beta (A4) precursor protein-binding, family B, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Apbb2  amyloid beta (A4) precursor protein-binding, family B, member 2  RGD1562438_predicted  similar to amyloid beta (A4) precursor protein-binding, family B, member 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562438_predicted  similar to amyloid beta (A4) precursor protein-binding, family B, member 2 (predicted)  LOC305338  similar to amyloid beta (A4) precursor protein-binding, family B, member 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC305338  similar to amyloid beta (A4) precursor protein-binding, family B, member 2      Symbol and Name status set to provisional 70820 PROVISIONAL